Gene
mllt11
- ID
- ZDB-GENE-030131-3007
- Name
- MLLT11 transcription factor 7 cofactor
- Symbol
- mllt11 Nomenclature History
- Previous Names
-
- fc23g02
- si:ch211-210h11.4
- wu:fc23g02 (1)
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to be involved in positive regulation of DNA-templated transcription; positive regulation of mitochondrial depolarization; and positive regulation of release of cytochrome c from mitochondria. Predicted to act upstream of or within apoptotic signaling pathway. Predicted to be located in centrosome; cytoplasm; and nucleus. Predicted to be active in cytosol and nucleoplasm. Is expressed in cranial ganglion; neurons; retina; retinal ganglion cell layer; and trigeminal placode. Orthologous to human MLLT11 (MLLT11 transcription factor 7 cofactor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7145990 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la013544Tg | Transgenic insertion | Unknown | Unknown | DNA |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | MLLT11 family | Putative WW-binding domain and destruction box |
|---|---|---|---|---|
| UniProtKB:A3KQS5 | InterPro |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mllt11-201
(1)
|
Ensembl | 1,330 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-312O15 | ZFIN Curated Data | |
| Contained in | BAC | CH211-210H11 | ZFIN Curated Data | |
| Encodes | EST | fc23g02 | ||
| Encodes | EST | IMAGE:7145990 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001159984 (1) | 1326 nt | ||
| Genomic | GenBank:BX927401 | 137958 nt | ||
| Polypeptide | UniProtKB:A3KQS5 (2) |
- Xu, H., Wang, G., Chi, Y.Y., Kou, Y.X., Li, Y. (2021) Expression profiling and functional characterization of the duplicated Oxr1b gene in zebrafish. Comparative biochemistry and physiology. Part D, Genomics & proteomics. 39:100857
- Giffen, K.P., Liu, H., Kramer, K.L., He, D.Z. (2019) Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Frontiers in neuroscience. 13:1117
- Tarifeño-Saldivia, E., Lavergne, A., Bernard, A., Padamata, K., Bergemann, D., Voz, M.L., Manfroid, I., Peers, B. (2017) Transcriptome analysis of pancreatic cells across distant species highlights novel important regulator genes. BMC Biology. 15:21
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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