Gene
tdo2a
- ID
- ZDB-GENE-030131-1187
- Name
- tryptophan 2,3-dioxygenase a
- Symbol
- tdo2a Nomenclature History
- Previous Names
-
- tdo2
- fb62b10
- wu:fb62b10
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable heme binding activity and tryptophan 2,3-dioxygenase activity. Predicted to be involved in protein homotetramerization; tryptophan catabolic process to acetyl-CoA; and tryptophan catabolic process to kynurenine. Predicted to act upstream of or within tryptophan catabolic process. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome and familial hypertryptophanemia. Orthologous to human TDO2 (tryptophan 2,3-dioxygenase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial hypertryptophanemia | Alliance | [?Hypertryptophanemia] | 600627 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Tryptophan 2,3-dioxygenase | Tryptophan/Indoleamine 2,3-dioxygenase-like |
|---|---|---|---|
|
UniProtKB:A7MBU6
|
406 | ||
|
UniProtKB:A0A8M9QAT4
|
300 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
tdo2a-204
(1)
|
Ensembl | 892 nt | ||
| mRNA |
tdo2a-201
(1)
|
Ensembl | 1,552 nt | ||
| ncRNA |
tdo2a-003
(1)
|
Ensembl | 747 nt | ||
| ncRNA |
tdo2a-004
(1)
|
Ensembl | 965 nt | ||
| ncRNA |
tdo2a-005
(1)
|
Ensembl | 720 nt | ||
| ncRNA |
tdo2a-006
(1)
|
Ensembl | 1,442 nt |
Interactions and Pathways
No data available
Plasmids
No data available