Gene

mc4r

ID

ZDB-GENE-021223-2

Name

melanocortin 4 receptor

Symbol

mc4r Nomenclature History

Previous Names

zMC4
si:dkey-151m6.62

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Exhibits melanocortin receptor activity. Involved in several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; energy homeostasis; and negative regulation of feeding behavior. Predicted to localize to integral component of membrane and plasma membrane. Human ortholog(s) of this gene implicated in morbid obesity and obesity. Is expressed in brain and myotome. Orthologous to human MC4R (melanocortin 4 receptor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

21 figures from 15 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mc4r Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Obesity (BMIQ20)	618406
		{Obesity, resistance to (BMIQ20)}	618406

Associated With mc4r Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR017452	GPCR, rhodopsin-like, 7TM
Family	IPR000155	Melanocortin 4 receptor
Family	IPR000276	G protein-coupled receptor, rhodopsin-like
Family	IPR001671	Melanocortin/ACTH receptor
Family	IPR001908	Melanocortin receptor 3-5