Gene

gdnfa

ID

ZDB-GENE-010226-1

Name

glial cell derived neurotrophic factor a

Symbol

gdnfa Nomenclature History

Previous Names

gdnf

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Exhibits MAP kinase kinase kinase activity. Involved in enteric nervous system development and protein-containing complex assembly. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in Hirschsprung's disease; congenital central hypoventilation syndrome; epilepsy; and pheochromocytoma. Is expressed in several structures, including brain; digestive system; eye; intermediate mesoderm; and lateral line system. Orthologous to human GDNF (glial cell derived neurotrophic factor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

27 figures from 15 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 10 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gdnfa Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		{Hirschsprung disease, susceptibility to, 3}	613711

Associated With gdnfa Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001839	Transforming growth factor-beta, C-terminal
Domain	IPR047020	Glial cell line-derived neurotrophic factor, TGF-beta-like domain
Family	IPR016649	Glial cell line-derived neurotrophic factor
Family	IPR043401	Glial cell line-derived neurotrophic factor family
Homologous_superfamily	IPR029034	Cystine-knot cytokine