ZFIN

ZFIN ID: ZDB-GENE-120117-1

ZFIN ID: ZDB-GENE-120117-1

CITATIONS (41 total)

Gene Name:	solute carrier family 16 member 2
Gene Symbol:	slc16a2

Owusu Poku, E., Fonte, M.R., Jensen, T.J., Inman, S.P., Mackin, R.D., Stenkamp, D.L. (2025) Thyroid hormone receptor beta-2 (TRβ2) overexpression modulates photoreceptor phenotype diversity in a ligand-dependent manner. Frontiers in cell and developmental biology. 13:16979301697930

Trindade, M., Silva, N., Rodrigues, J., Kawakami, K., Campinho, M.A. (2025) Maternal thyroid hormone is required to develop the hindbrain vasculature in zebrafish. Communications biology. 8:960960

Hill-Terán, G., Petrich, J., Falcone Ferreyra, M.L., Aybar, M.J., Coux, G. (2024) Untangling Zebrafish Genetic Annotation: Addressing Complexities and Nomenclature Issues in Orthologous Evaluation of TCOF1 and NOLC1. Journal of molecular evolution. 92(6):744-760

Lazcano, I., Pech-Pool, S.M., Maldonado-Lira, M.F., Olvera, A., Darras, V.M., Orozco, A. (2024) Ontogeny of Thyroid Hormone Signaling in the Retina of Zebrafish: Effects of Thyroidal Status on Retinal Morphology, Cell Survival, and Color Preference. International Journal of Molecular Sciences. 25(22):

Silva, N., Campinho, M.A. (2023) In a zebrafish biomedical model of human Allan-Herndon-Dudley syndrome impaired MTH signaling leads to decreased neural cell diversity. Frontiers in endocrinology. 14:11576851157685

Rozenblat, R., Tovin, A., Zada, D., Lebenthal-Loinger, I., Lerer-Goldshtein, T., Appelbaum, L. (2022) Genetic and Neurological Deficiencies in the Visual System of mct8 Mutant Zebrafish. International Journal of Molecular Sciences. 23(5):

Wasserman-Bartov, T., Admati, I., Lebenthal-Loinger, I., Sharabany, J., Lerer-Goldshtein, T., Appelbaum, L. (2022) Tsh induces Agrp1 neuron proliferation in Oatp1c1 deficient zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 42(44):8214-8224

Chu, S., Kwon, B.R., Lee, Y.M., Zoh, K.D., Choi, K. (2021) Effects of 2-ethylhexyl-4-methoxycinnamate (EHMC) on thyroid hormones and genes associated with thyroid, neurotoxic, and nephrotoxic responses in adult and larval zebrafish (Danio rerio). Chemosphere. 263:128176

Kim, J., Lee, G., Lee, Y.M., Zoh, K.D., Choi, K. (2021) Thyroid disrupting effects of perfluoroundecanoic acid and perfluorotridecanoic acid in zebrafish (Danio rerio) and rat pituitary (GH3) cell line. Chemosphere. 262:128012

Song, J., Lu, Y., Cheng, X., Shi, C., Lou, Q., Jin, X., He, J., Zhai, G., Yin, Z. (2021) Functions of the Thyroid-Stimulating Hormone on Key Developmental Features Revealed in a Series of Zebrafish Dyshormonogenesis Models. Cells. 10(8):

Walter, K.M., Singh, L., Singh, V., Lein, P.J. (2021) Investigation of NH3 as a selective thyroid hormone receptor modulator in larval zebrafish (Danio rerio). Neurotoxicology. 84:96-104

Kim, S., Stroski, K.M., Killeen, G., Smitherman, C., Simcik, M.F., Brooks, B.W. (2020) 8:8 Perfluoroalkyl phosphinic acid affects neurobehavioral development, thyroid disruption, and DNA methylation in developing zebrafish. The Science of the total environment. 736:139600

Admati, I., Wasserman-Bartov, T., Tovin, A., Rozenblat, R., Blitz, E., Zada, D., Lerer-Goldshtein, T., Appelbaum, L. (2019) Neural alterations and hyperactivity of the hypothalamic-pituitary-thyroid axis in Oatp1c1-deficiency. Thyroid : official journal of the American Thyroid Association. 30(1):161-174

Groeneweg, S., Kersseboom, S., van den Berge, A., Dolcetta-Capuzzo, A., van Geest, F.S., van Heerebeek, R.E.A., Arjona, F.J., Meima, M., Peeters, R., Visser, W.E., Visser, T.J. (2019) In vitro characterization of human, mouse and zebrafish MCT8 orthologues. Thyroid : official journal of the American Thyroid Association. 29(10):1499-1510

Lazcano, I., Rodríguez-Ortiz, R., Villalobos, P., Martínez-Torres, A., Solís-Saínz, J.C., Orozco, A. (2019) Knock-Down of Specific Thyroid Hormone Receptor Isoforms Impairs Body Plan Development in Zebrafish. Frontiers in endocrinology. 10:156

Walter, K.M., Dach, K., Hayakawa, K., Giersiefer, S., Heuer, H., Lein, P.J., Fritsche, E. (2019) Ontogenetic expression of thyroid hormone signaling genes: An in vitro and in vivo species comparison. PLoS One. 14:e0221230

Walter, K.M., Miller, G.W., Chen, X., Harvey, D.J., Puschner, B., Lein, P.J. (2019) Changes in Thyroid Hormone Activity Disrupt Photomotor Behavior of Larval Zebrafish. Neurotoxicology. 74:47-57

Wang, X., Ling, S., Guan, K., Luo, X., Chen, L., Han, J., Zhang, W., Mai, B.X., Zhou, B. (2019) Bioconcentration, biotransformation, and thyroid endocrine disruption of decabromodiphenyl ethane (DBDPE), a novel brominated flame retardant, in zebrafish larvae. Environmental science & technology. 53(14):8437-8446

Walter, K.M., Miller, G.W., Chen, X., Yaghoobi, B., Puschner, B., Lein, P.J. (2018) Effects of Thyroid Hormone Disruption on the Ontogenetic Expression of Thyroid Hormone Signaling Genes in Developing Zebrafish (Danio rerio). General and comparative endocrinology. 272:20-32

Silva, N., Louro, B., Trindade, M., Power, D.M., Campinho, M.A. (2017) Transcriptomics reveal an integrative role for maternal thyroid hormones during zebrafish embryogenesis. Scientific Reports. 7:16657

Zada, D., Tovin, A., Lerer-Goldshtein, T., Appelbaum, L. (2016) Pharmacological and BBB-targeted genetic therapies for thyroid hormone-dependent hypomyelination. Disease models & mechanisms. 9(11):1339-1348

Campinho, M.A., Saraiva, J., Florindo, C., Power, D.M. (2014) Maternal thyroid hormones are essential for neural development in zebrafish. Molecular endocrinology (Baltimore, Md.). 28(7):1136-49

de Vrieze, E., van de Wiel, S.M., Zethof, J., Flik, G., Klaren, P.H., Arjona, F.J. (2014) Knockdown of monocarboxylate transporter 8 (mct8) disturbs brain development and locomotion in zebrafish. Endocrinology. 155(6):2320-30

Muzzio, A.M., Noyes, P.D., Stapleton, H.M., Lema, S.C. (2014) Tissue distribution and thyroid hormone effects on mRNA abundance for membrane transporters Mct8, Mct10, and organic anion-transporting polypeptides (Oatps) in a teleost fish. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 167:77-89

Zada, D., Tovin, A., Lerer-Goldshtein, T., Vatine, G.D., Appelbaum, L. (2014) Altered Behavioral Performance and Live Imaging of Circuit-Specific Neural Deficiencies in a Zebrafish Model for Psychomotor Retardation. PLoS Genetics. 10:e1004615

Vatine, G.D., Zada, D., Lerer-Goldshtein, T., Tovin, A., Malkinson, G., Yaniv, K., and Appelbaum, L. (2013) Zebrafish as a model for monocarboxyl transporter 8-deficiency. The Journal of biological chemistry. 288(1):169-180

Arjona, F.J., de Vrieze, E., Visser, T.J., Flik, G., and Klaren, P.H. (2011) Identification and Functional Characterization of Zebrafish Solute Carrier Slc16a2 (Mct8) as a Thyroid Hormone Membrane Transporter. Endocrinology. 152(12):5065-73

Additional Citations (14):

ZFIN Staff (2024) Association of Ensembl transcripts with ZFIN genes. Semi-automated Curation.

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2022) Electronic Gene Ontology annotations created by ARBA machine learning models. Automated Data Submission.

Zebrafish Nomenclature Committee (2021) Nomenclature Data Curation (2021). Nomenclature Committee Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

ZFIN Staff (2015) Data Model Change: Sequence Targeting Reagents Removed from Environment. ZFIN Historical Data.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

GOA, HGNC, AgBase and UniProtKB curators (2007) Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity. ZFIN Direct Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Scientific Curation. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.