Liu et al., 2014 - Histopathologic alterations associated with global gene expression due to chronic dietary TCDD exposure in juvenile zebrafish. PLoS One   9:e100910 Full text @ PLoS One

Fig. 5

TCDD caused cystic degeneration in nasal epithelium in zebrafish after 42 d of dietary exposure.

A) Well differentiated, orderly, uniform lamella (arrow) of zebrafish in 0 ppb group; B) cystic degeneration of nasal epithelium (arrows) was found in 100 ppb TCDD-treated zebrafish at 42 d (40X).

Fig. 6

TCDD caused disruption of ovary development in zebrafish at 42 d.

A) Ovulated vitellogenic follicles (V) in mature ovary of zebrafish in 0 ppb group; B) immature ovary in fish treated with 100 ppb TCDD. Ovary lacks vitellogenic follicles. Moderate interstitial edema (arrows) was observed; only previtellogenic oocytes are present: cortical alveolar oocytes (C) and perinucleolar oocytes (P) (10X).

Fig. 7

TCDD induced hemopoietic hypoplasia in kidney at 42 d.

A) Normal hemopoietic tissue (arrow) in interstitium of anterior kidney of zebrafish in 0 ppb group; B) depletion of hemopoietic tissue (arrow) from interstitium of anterior kidney of zebrafish in 100 ppb group at 42 d (40X).

Fig. 8

TCDD caused pericardial edema in zebrafish at 42 d.

A) Normal heart in zebrafish of 0 ppb group; B) pericardial edema (arrow) in fish fed 100 ppb TCDD at 42 d (5X).

Acknowledgments:
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS One