Genomic Feature
m520
- ID
- ZDB-ALT-980203-725
- Name
- m520
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Driever Lab
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 17: 34234220 (GRCz11) (1) Details
- Nucleotide change
- C/T
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- C>T (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Arg>Stop at position 546 (1)
- Flanking Sequence
-
GTTTACTCGAGAAATGCTTAATTCCTTGTAAGCACACATTGAAGCAATGTGTACCATTTTTTTTTTCAGCTTATGCTATTGTGTGTACAGTGCAAAAATAAATATACGAGCTAAATATATGCAGAGTTTGTACAGATTTGAAAAAATCTAGATTTGCAAAAGTTAGTCTGTATGATTTGTGTGCTGATGAAGAAATTGTAGCAGACTTGTACATACAAAATATTTCCTGTTCATCTACAGACTTTGATAATGAGGAGATTCTCACATATGAAGAAATGGCACTTTACCACCAACCAGCCAATCGTAAGCGGCCCATCGCACTAATCGGCCCACCGAACTGTGGGCAAAATGAGCTCAGACAAAGACTCCTCTCCACTGAGCCGGACAGGTTTGCTGGACCTGTTCCTCGTAAGTGTCAGAAAACCTTTTGTTTATCAGCTTGATCTATTCTGTAATATCCTAAACAGGAATCTCTCTTTGCTTCAGACACCACACGGAGT
C/T GACGTGACGCTGAGGCGAACGGCCGTGACTACCACTTTGTGTCCCGCCAGGCCTTCGAGATGGACTCTGCAGCAGGGAAATTCATAGAGTCCGGAGAGTTTGAAAAGAACTTTTACGGCACCAGCACAGACTCTGTCCGACAAGTCATCAACACAGGCAAAATCTGCCTCCTGTGCGTACACACCCAGGTGAGAAACAGTGCTGCAATGCCTCGTGATCTTCAACAACATCCTAGCACAGCAGGTCTTCAGTCCTGCTCTTGGAGGGCTAATTTCCTGCAGATTATCTCCAGTGCATTTGAGCTTTTAATGATCTTGAAGACCTGTCCTGCACTCATAATGGATAGTAGTACCTACTGTAGGGTATTGGAAATGAAGTATGTTCTATTTCAGAGACTATGGTGAATAGGCTTTTAAATGACACTCTCAAACTAGTTTTGGTTAATGATCAGTAGAGTGGTATGAGACACCACAGTTTAAAATAAAAATAAGTTAAATATA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| pals1am520/m520 | Homozygous | ♀+/- ♂+/- | 11 figures  from 6 publications | 6 figures from 4 publications | |
| pals1am520/m520 (AB) | Homozygous | Unknown | 4 figures from 4 publications | 3 figures from 3 publications | |
| pals1am520/+ (AB) | Heterozygous | Unknown | |||
| pals1am520/m520; kj9Tg | Complex | Fig. 2 from Zou et al., 2012 | |||
| pals1am520/m520; mi2001Tg | Complex | Fig. 2 from Zou et al., 2012 | |||
| pals1am520/m520; pt106Tg/+ | Complex | 2 figures from Zou et al., 2008 | 2 figures from Zou et al., 2008 | ||
| pals1am520/m520; pt112Tg | Complex | Fig. 2 from Zou et al., 2012 | |||
| pals1am520/m520; pt137Tg | Complex | Fig. 6 from Guo et al., 2018 | |||
| pals1am520/m520; s854Tg | Complex | Fig. S2 from Bagnat et al., 2007 | |||
| pals1am520; twu34Tg | Complex | Fig. 1 from Cibrian-Uhalte et al., 2007 |
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Supplemental Information
- Genotyping protocol
- None
- Guo, C., Zou, J., Wen, Y., Fang, W., Stolz, D.B., Sun, M., Wei, X. (2018) Apical Cell-Cell Adhesions Reconcile Symmetry and Asymmetry in Zebrafish Neurulation. iScience. 3:63-85
- Ichimura, K., Fukuyo, Y., Nakamura, T., Powell, R., Sakai, T., Janknecht, R., and Obara, T. (2013) Developmental Localization of Nephrin in Zebrafish and Medaka Pronephric Glomerulus. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 61(4):313-324
- Luz, M., and Knust, E. (2013) Fluorescently tagged Lin7c is a dynamic marker for polarity maturation in the zebrafish retinal epithelium. Biology Open. 2(9):867-871
- Zou, J., Wen, Y., Yang, X., and Wei, X. (2013) Spatial-temporal expressions of Crumbs and Nagie oko and their interdependence in zebrafish central nervous system during early development. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 31(8):770-782
- Ichimura, K., Fukuyo, Y., Nakamura, T., Powell, R., Sakai, T., and Obara, T. (2012) Structural disorganization of pronephric glomerulus in zebrafish mpp5a/nagie oko mutant. Developmental Dynamics : an official publication of the American Association of Anatomists. 241(12):1922-1932
- Zou, J., Wang, X., and Wei, X. (2012) Crb Apical Polarity Proteins Maintain Zebrafish Retinal Cone Mosaics via Intercellular Binding of Their Extracellular Domains. Developmental Cell. 22(6):1261-1274
- Beyer, J., Zhao, X.C., Yee, R., Khaliq, S., McMahon, T.T., Ying, H., Yue, B.Y., and Malicki, J.J. (2010) The role of crumbs genes in the vertebrate cornea. Investigative ophthalmology & visual science. 51(9):4549-4556
- Zhang, J., Piontek, J., Wolburg, H., Piehl, C., Liss, M., Otten, C., Christ, A., Willnow, T.E., Blasig, I.E., and Abdelilah-Seyfried, S. (2010) Establishment of a neuroepithelial barrier by Claudin5a is essential for zebrafish brain ventricular lumen expansion. Proceedings of the National Academy of Sciences of the United States of America. 107(4):1425-1430
- Bit-Avragim, N., Hellwig, N., Rudolph, F., Munson, C., Stainier, D.Y., and Abdelilah-Seyfried, S. (2008) Divergent polarization mechanisms during vertebrate epithelial development mediated by the Crumbs complex protein Nagie oko. Journal of Cell Science. 121(Pt 15):2503-2510
- Kagemann, L., Ishikawa, H., Zou, J., Charukamnoetkanok, P., Wollstein, G., Townsend, K.A., Gabriele, M.L., Bahary, N., Wei, X., Fujimoto, J.G., and Schuman, J.S. (2008) Repeated, noninvasive, high resolution spectral domain optical coherence tomography imaging of zebrafish embryos. Molecular Vision. 14:2157-2170
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