Genomic Feature
m139
- ID
- ZDB-ALT-980203-477
- Name
- m139
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Driever Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 11: 30600204 (GRCz11) (1) Details
- Nucleotide change
- G/A
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- C>T (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation: Arg>Stop at position 400 (1)
- Flanking Sequence
-
TGTACGTACCACCTTCACCTCCATCATGCCAATGCTTTCACTGATATGAACAATTGGTTCCTCAAATAAGAAGATGCCAGCATGGTCATCATCAAAGATAGTCACGGTAGCTGTTGAAGGAAGGCCAAGACCAGCTAAAGCGTCCACATGATTGGTACCTGGGTTTCCATTGTTGGCTCCTTCAGATATGACCTTGACATTGCTGAGATGAACCAGGAAGTGTTCATCTTCTTCAAATATATCATCGTCGATAATGTCCACTCTAATCTCCTTTTCGGTCTCACCTGGTTTGAAGATTATGACACCCTCAGTGAACTGGTAATCAGAACCTGCATTGGCAGTGCCATCCTCAGTTCTGTACTCCACTGACACAGTGCTGGTTAAGTCGCCGCCGCGTCGAACCACGTTCAAAGCCACAGTTCCACAGTTCTCCAAACACTGATATGTCCCAGGGTCGAAGAAAATCTTGGAGGAGATATCATTATCGGAGACTTCCGATC
G/A AAGTTCATGGATACCAAGTGCTTTTCTGGCTTGATCTGCAGCATGTTTCTTCAGTATATTTCCTGCACCAGTCATAAGTCTAGTGGCCTGACAGCGATAGAAAGCACGGCTCTTCTGTTGCTGGCTGAGGACGTGGTAGTTGGCAAGCTCAACAAGCTGCTCCATCTCCTTTTCCGGATGCTTCTGTTTCAGTTCCTTCAAAATCTTGGCCATTTCCCTTCTGGCCTCGTCCTCATCCGCGTCTTTATCTTCATTATCAACTGCGCCGTCTAAAAACTCCTCGGCATGAGAGTTAAGCATCCCGCCATCCATTTCGATATCAGCCTTTGACTGGAGTTCTGGTTCACCTTCAGTCTCTATAATTATCCCACGTTTCTTTCCAACTCTGTAACGTTTATACACGTATTTGTAAAACAGAAGTCTACGGTCTGCAACCCAAGCAAATAATACACAAATAGGAAAGAAAAACAGAGTAAGAAGTCCCTCCCAGACCTCCACGA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| slc8a1am139/m139 | Homozygous | ♀+/- ♂+/- | Table 1 from Chen et al., 1996 | ||
| slc8a1am139/m139 (AB) | Homozygous | ♀+/- ♂+/- | 5 figures  from 3 publications | 3 figures from Ebert et al., 2005 |
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Supplemental Information
- Genotyping protocol
- None
- Ebert, A.M., Hume, G.L., Warren, K.S., Cook, N.P., Burns, C.G., Mohideen, M.A., Siegal, G., Yelon, D., Fishman, M.C., and Garrity, D.M. (2005) Calcium extrusion is critical for cardiac morphogenesis and rhythm in embryonic zebrafish hearts. Proceedings of the National Academy of Sciences of the United States of America. 102(49):17705-17710
- Chen, J.N., Haffter, P., Odenthal, J., Vogelsang, E., Brand, M., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., and Nüsslein-Volhard, C. (1996) Mutations affecting the cardiovascular system and other internal organs in zebrafish. Development (Cambridge, England). 123:293-302
- Driever, W., Solnica-Krezel, L., Schier, A.F., Neuhauss, S.C., Malicki, J., Stemple, D.L., Stainier, D.Y., Zwartkruis, F., Abdelilah, S., Rangini, Z., Belak, J., and Boggs, C. (1996) A genetic screen for mutations affecting embryogenesis in zebrafish. Development (Cambridge, England). 123:37-46
- Stainier, D.Y., Fouquet, B., Chen, J.N., Warren, K.S., Weinstein, B.M., Meiler, S.E., Mohideen, M.A., Neuhauss, S.C., Solnica-Krezel, L., Schier, A.F., Zwartkruis, F., Stemple, D.L., Malicki, J., Driever, W., and Fishman, M.C. (1996) Mutations affecting the formation and function of the cardiovascular system in the zebrafish embryo. Development (Cambridge, England). 123:285-292
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