Gene

slc8a1a

ID

ZDB-GENE-050809-1

Name

solute carrier family 8 member 1a

Symbol

slc8a1a Nomenclature History

Previous Names

ncx1 (1)
ncx1a (1)
ncx1h (1)
tre
tremblor

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Enables calcium:sodium antiporter activity. Acts upstream of or within several processes, including calcium ion transport; cellular calcium ion homeostasis; and sarcomere organization. Predicted to be located in membrane. Predicted to be active in axon; postsynapse; and sarcolemma. Is expressed in heart primordium and pericardial region. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human SLC8A1 (solute carrier family 8 member A1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

10 figures from 9 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 28 figures from 9 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With slc8a1a Human Ortholog

No data available

Associated With slc8a1a Via Experimental Models

Human Disease	Fish	Conditions	Citations
atrial fibrillation	slc8a1a^{tc318d/tc318d}; twu34Tg	standard conditions	Sander et al., 2021

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003644	Na-Ca exchanger/integrin-beta4
Domain	IPR004837	Sodium/calcium exchanger membrane region
Domain	IPR032452	Sodium/calcium exchanger domain, C-terminal extension
Family	IPR004836	Sodium/calcium exchanger protein
Family	IPR051171	Calcium/Cation Antiporter
Homologous_superfamily	IPR038081	CalX-like domain superfamily
Homologous_superfamily	IPR044880	NCX, central ion-binding domain superfamily

Domain Details Per Protein

Protein	Length	Calcium/Cation Antiporter	CalX-like domain superfamily	Na-Ca exchanger/integrin-beta4	NCX, central ion-binding domain superfamily	Sodium/calcium exchanger domain, C-terminal extension	Sodium/calcium exchanger membrane region	Sodium/calcium exchanger protein
UniProtKB:F1R4F4 InterPro	969
UniProtKB:A0A286YBI0 InterPro	933
UniProtKB:Q32SG8 InterPro	974
UniProtKB:A0A8M9QLM2 InterPro	338

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	slc8a1a-201 (1) Ensembl	Ensembl	2,892 nt	Select Tool ZFIN BLAST
mRNA	slc8a1a-202 (1) Ensembl	Ensembl	3,647 nt	Select Tool ZFIN BLAST
mRNA	slc8a1a-203 (1) Ensembl	Ensembl	2,925 nt	Select Tool ZFIN BLAST
mRNA	slc8a1a-204 (1) Ensembl	Ensembl	3,289 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations