Gene
slc8a1a
- ID
- ZDB-GENE-050809-1
- Name
- solute carrier family 8 member 1a
- Symbol
- slc8a1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Enables calcium:sodium antiporter activity. Acts upstream of or within several processes, including enteric nervous system development; intracellular calcium ion homeostasis; and sarcomere organization. Predicted to be located in membrane. Predicted to be active in axon; postsynapse; and sarcolemma. Is expressed in heart primordium and pericardial region. Used to study atrial fibrillation. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human SLC8A1 (solute carrier family 8 member A1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 28 figures from 9 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| atrial fibrillation | slc8a1atc318d/tc318d; twu34Tg | standard conditions | Sander et al., 2021 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003644 | Na-Ca exchanger/integrin-beta4 |
| Domain | IPR004837 | Sodium/calcium exchanger membrane region |
| Domain | IPR032452 | Sodium/calcium exchanger domain, C-terminal extension |
| Family | IPR004836 | Sodium/calcium exchanger protein |
| Family | IPR051171 | Calcium/Cation Antiporter |
| Homologous_superfamily | IPR038081 | CalX-like domain superfamily |
| Homologous_superfamily | IPR044880 | NCX, central ion-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Calcium/Cation Antiporter | CalX-like domain superfamily | Na-Ca exchanger/integrin-beta4 | NCX, central ion-binding domain superfamily | Sodium/calcium exchanger domain, C-terminal extension | Sodium/calcium exchanger membrane region | Sodium/calcium exchanger protein |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1R4F4 | InterPro | 969 | |||||||
| UniProtKB:A0A286YBI0 | InterPro | 933 | |||||||
| UniProtKB:Q32SG8 | InterPro | 974 | |||||||
| UniProtKB:A0A8M9QLM2 | InterPro | 338 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc8a1a-201
(1)
|
Ensembl | 2,892 nt | ||
| mRNA |
slc8a1a-202
(1)
|
Ensembl | 3,647 nt | ||
| mRNA |
slc8a1a-203
(1)
|
Ensembl | 2,925 nt | ||
| mRNA |
slc8a1a-204
(1)
|
Ensembl | 3,289 nt |
Interactions and Pathways
No data available
Plasmids
No data available