Genomic Feature
m129
- ID
- ZDB-ALT-980203-463
- Name
- m129
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (2)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Driever Lab
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 2: 37372089 (GRCz11) (1) Details
- Nucleotide change
- G/A
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- C>T at position 1519 (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Arg>Stop (1)
- Flanking Sequence
-
TTAAACGCTAATGCTGTCTAAACTAATGCTCAAGACACAAAAAACCTCAAAAAAGTACTCCAGGGTGTCTTAAAACCTTTAATTTTGACGCCACAAATAAGTTCTTGACTTTTAAATCTAACGTTTGTAATCTTAAAATACACCCCTCACTTTTCTGTTTGTGTAAAAAAAAAATATACACAAAACTAATAGGATGTGTTTATAATGACTCATTTTTGGGTGAGCTATACTTTCAAAGCTGACGCTGCTGAAATGCTACTTGAAGTGGTAAGAGCTCACGACCAAATTACAGGAATGACTAATCAAATGAAGGATTCCTCAAGGTCATAAACAACAGTAAACAGCTCTTCAGGCTCCAGTAAGTCCTCTGTTTAGTTTCACTAACGTCAGGCTAGAGAGAATGACTCATTGCTTCCTCTGCGTCTCGAGTCAAAACATCCAAGAAGACAGATAAAGGAAACGGAGATAACAATGACTCACAAGATCCCAGTCTACATTTC
G/A GAAAAAAGGATGGGCCATGATGTCTGCGAAGCCTGTCTGAGGATGACATCCCAGCCGTTCCTTCGACTCCTACAAAAAAAAGGACTGAATGTCAGTGAGAAGAAATAAGATATATTTTAGTTCTTTTTTGCTCTAATTGTCCAGCTAATAGTTTGCTAACAGTCTAATTTGATATTCATCTGGTCTTTGTATGAATAAAACCGAAAAAGTATTATGTACAATATTAGACTAAAAAAGAGGATCTTCATATTGCTGCTTTTCTGGTGATTTAACTTGCTTCTATTGACCTCATTTGTGAGTTGCTTTGAAAAAAACATCTGCTAAATCAATAAGTGTAAATGCAAAGAGATGAACAGACACACAGAATGATTAACACACAACAGAAGGAAATAAAGTAAAGAATGATTATGGCAGCACTATAACAAGCTCATCTGACGTAAGGACATTAGCATTGATCTGTCTGGTCTGCTTCACCTTGTTGAGGAATCCCTTCAGCACGC - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| prkcim129/m129 | Homozygous | Unknown | Fig. 4 from Rohr et al., 2008 | ||
| prkcim129/m129 | Homozygous | ♀+/- ♂+/- | Fig. 4  from Wiweger et al., 2012 | ||
| prkcim129/m129 (AB) | Homozygous | Unknown | 5 figures from 4 publications | ||
| prkcim129/+ (AB) | Heterozygous | Unknown | |||
| prkcim129/m129; md3Tg | Complex | Fig. 4 from Rohr et al., 2008 | Fig. 4 from Rohr et al., 2008 |
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Supplemental Information
- Genotyping protocol
- None
- Kannan, R.R., Iniyan, A.M., Vincent, S.G. (2015) Chemical genetic effects of Sargassum wightii during embryonic development in zebrafish. Indian journal of pharmacology. 47:195-8
- Wiweger, M.I., Zhao, Z., van Merkesteyn, R.J., Roehl, H.H., and Hogendoornm, P.C. (2012) HSPG-Deficient Zebrafish Uncovers Dental Aspect of Multiple Osteochondromas. PLoS One. 7(1):e29734
- Rohr, S., Otten, C., and Abdelilah-Seyfried, S. (2008) Asymmetric involution of the myocardial field drives heart tube formation in zebrafish. Circulation research. 102(2):e12-19
- Cui, S., Otten, C., Rohr, S., Abdelilah-Seyfried, S., and Link, B.A. (2007) Analysis of aPKClambda and aPKCzeta reveals multiple and redundant functions during vertebrate retinogenesis. Molecular and cellular neurosciences. 34(3):431-444
- Kazakova, N., Li, H., Mora, A., Jessen, K.R., Mirsky, R., Richardson, W.D., and Smith, H.K. (2006) A screen for mutations in zebrafish that affect myelin gene expression in Schwann cells and oligodendrocytes. Developmental Biology. 297(1):1-13
- Tsujikawa, M., and Malicki, J. (2004) Genetics of photoreceptor development and function in zebrafish. The International journal of developmental biology. 48(8-9):925-934
- Geldmacher-Voss, B., Reugels, A.M., Pauls, S., and Campos-Ortega, J.A. (2003) A 90° rotation of the mitotic spindle changes the orientation of mitoses of zebrafish neuroepithelial cells. Development (Cambridge, England). 130(16):3767-3780
- Horne-Badovinac, S., Lin, D., Waldron, S., Schwarz, M, Mbamalu, G., Pawson, T., Jan, Y.-N., Stainier, D.Y.R., and Abdelilah-Seyfried, S. (2001) Positional cloning of heart and soul reveals multiple roles for PKCl in zebrafish organogenesis. Current biology : CB. 11(19):1492-1502
- Peterson, R.T., Mably, J.D., Chen, J.-N., and Fishman, M.C. (2001) Convergence of distinct pathways to heart patterning reveals by the small molecule concentramide and the mutation heart-and-soul. Current biology : CB. 11:1481-1491
- Malicki, J. (2000) Harnessing the power of forward genetics – analysis of neuronal diversity and patterning in the zebrafish retina. Trends in neurosciences. 23(11):531-541
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