Genomic Feature
tm205
- ID
- ZDB-ALT-980203-1789
- Name
- tm205
- Synonyms
-
- AM005A (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
-
Zebrafish International Resource Center (ZIRC)
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European Zebrafish Resource Center (EZRC) ( order this ) - Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 7: 26082380 (GRCz11) (1) Details
- Nucleotide change
- G/T
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- C>A (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation: Tyr>Stop at position 139 (1)
- Flanking Sequence
-
AAGAAAACCCCATCGACGACAGGCACAAAGGAAAAGCGGAAAAGGCTGCTCCAGGGAAGAACTTGCCACTCTTGATCAATTAGTTCCTGTGGATGTTTATTCCTCAGACAATCAATCAGTTCAGTATCATTGCCCCAGGTGCAACCAACCAGTTTGCCCAACTTGGTGGTTCTCCGACGGGCCTCATCAAAGGTAACAGTGGCCCAGGGTGTATTTGGAACACCACTCTGCAATATGGCACGTGTGAAGAGGGGGCGGCTGTCTGGTGACAGAACATGCATGCCAACTGATGCTGCCCCAGCACTTTCTCCAAAAATGGTGACCTGTTTTGGGTTACCGCCAAAGAAGTGGATGTTTTCTTGTACCCACTGGAGGGCCAATCTCTGGTCATAGAGACCCACGTTTCCAGGTGCGTCTGATGAGCCATTAAGAGCAAGGAATCCAAAAGCTCCAACACGATAGTTCATAGACACAACCACTACCTTTTCAGTGTAAGCCAG
G/T TAACGGCCATCATAGACATCAAGAGAGGAAGAGCCACTATAGAAGCCACCACCATATATCCAGACCATAACTGTGAGGTTCTGTGGTCTGGGCGTAGGAGGTACCCACACATTCAGATAAAGACAGTCTTCACTCATCACTCTGTTGGGGTTCCACATTTCAATACCTGGAAAGCCCGGGTAAGAGGTATCCACAAACTGATAGCAGGCATTTGAGAACTCTTTAGCCTCAAAGACATTATTCCAGGGCTTTTTGGGCTCAGCTCTCTTGAAACGCCTCTTCCCAATGGGTGGTTCAGCATATGGGATGCCTAAGAAAGCAATCACATGACTCCGGTCTGGAACAGGCAATCTTGTACCCTGCACTCTGCCCAATCTTGTTGCTACTACGAGGTCAGGTTCAGCCTGTGCGAAACAGTTATGGAAGAGGAACGTGAGTAGCACAGTGGGCAAGAGCAAAATATCTGAGGTCTTCATGGCTTCTTTTCACTTGTTGGCTGG - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| achetm205/tm205 | Homozygous | ♀+/- ♂+/- | 5 figures from 4 publications | ||
| achetm205/+ (AB) | Heterozygous | Unknown |
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Supplemental Information
- Genotyping protocol
- tm205.pdf
- Mongeon, R., Walogorsky, M., Urban, J., Mandel, G., Ono, F., and Brehm, P. (2011) An acetylcholine receptor lacking both γ and ε subunits mediates transmission in zebrafish slow muscle synapses. The Journal of general physiology. 138(3):353-66
- Downes, G.B., and Granato, M. (2004) Acetylcholinesterase function is dispensable for sensory neurite growth but is critical for neuromuscular synapse stability. Developmental Biology. 270(1):232-245
- Granato, M., van Eeden, F.J., Schach, U., Trowe, T., Brand, M., Furutani-Seiki, M., Haffter, P., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., and Nüsslein-Volhard, C. (1996) Genes controlling and mediating locomotion behavior of the zebrafish embryo and larva. Development (Cambridge, England). 123:399-413
- Haffter, P., Granato, M., Brand, M., Mullins, M.C., Hammerschmidt, M., Kane, D.A., Odenthal, J., van Eeden, F.J., Jiang, Y.J., Heisenberg, C.P., Kelsh, R.N., Furutani-Seiki, M., Vogelsang, E., Beuchle, D., Schach, U., Fabian, C., and Nüsslein-Volhard, C. (1996) The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development (Cambridge, England). 123:1-36
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