Gene

ache

ID
ZDB-GENE-010906-1
Name
acetylcholinesterase
Symbol
ache Nomenclature History
Previous Names
  • zgc:92550
  • ziehharmonika (1)
  • zim (1)
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Exhibits acetylcholinesterase activity. Involved in several processes, including acetylcholine catabolic process; cellular response to methanol; and response to amphetamine. Predicted to localize to extracellular region; plasma membrane; and synapse. Is expressed in several structures, including female organism; male organism; myotome; nervous system; and neural tube. Human ortholog(s) of this gene implicated in Alzheimer's disease; epilepsy; and myasthenia gravis. Orthologous to human ACHE (acetylcholinesterase (Cartwright blood group)).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
20 figures from 13 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
22 figures from 9 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ache Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
[Blood group, Yt system] 112100
Associated With ache Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR019826 Carboxylesterase type B, active site
Conserved_site IPR019819 Carboxylesterase type B, conserved site
Domain IPR002018 Carboxylesterase, type B
Domain IPR014788 Acetylcholinesterase, tetramerisation domain
Family IPR000997 Cholinesterase
Homologous_superfamily IPR029058 Alpha/Beta hydrolase fold
Domain Details Per Protein
Protein Length Acetylcholinesterase, tetramerisation domain Alpha/Beta hydrolase fold Carboxylesterase, type B Carboxylesterase type B, active site Carboxylesterase type B, conserved site Cholinesterase
UniProtKB:Q6DHA5 215
UniProtKB:Q9DDE3 634
UniProtKB:B3DKL4 634
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations