Genomic Feature
tx230
- ID
- ZDB-ALT-980203-1371
- Name
- tx230
- Synonyms
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
-
Zebrafish International Resource Center (ZIRC)
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European Zebrafish Resource Center (EZRC) ( order this ) - Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 7: 53100434 (GRCz11) (1) Details
- Nucleotide change
- T/A
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- A>T (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Lys>Stop at position 547 (1)
- Flanking Sequence
-
ACTCTCAGGACCACCTTGTATTCACCCTGTTCCAACTGAGATTGAGGCTTGATATTCAGAAAATGACCAGTTTCTATAATTGGCAAATGTAATAGTTAGAGATGTCCACTCAAAGTCAGATGAACTATATATATATATATAAAATAAAACAAACATTTACTCACCATTGAAAAAAACAGACCAATTTTTACTGGTATCACCTTGGGGCTCAACTTTGAAGGGACCAGCAAAAGGAGGTAAATCTTTGTCCGTTATAGAGAGAAGCACTGGGGCTGATTCACGATTGCACAATTTTATGGTCCTTTCATTAATAACAGGAGCATTGTCATTTACATCCTGCAGTTCAATTACCAGTGTTCCTGTGCCAGTTGCTGGAGACTCAACTGCAAACAACATTTGTTCAAAGATTAGACAAAAAACAAATAACTAAAAATCTAGACAGGAACTTTAAGAAAAATAAAATACTCTACCATCATTATCCAAAGCCAAAATGAGAGCTT
T/A GTATTTGCCATCTTTGACATTGGAAGATTCTCGATCCAAAGCATTCTTGACTTGAATCTGCCCAGAGCCTGTTATATTGAGCCAGTCAGAAGGATCATTTCCAATTCTATAACTGTAAGGAGCCAAAACATACAGGTTAAATGCTAAGCAAGAACTATGCAGTGTTATTTTACATTTAATTATCTGTACCTAAATACTGTTAAACTCCCCAAGAAACCATAAAGCACTGTTTATTTACTTCCTTTGGTCAATTGTATTGATCTAGGCTTGCAATTTGTTTAATTTTATGCACAATTTCCCAACAAAGTCATCCCAAATAATCTAAATCAATGAATTCCTTCCAAACAAAGCTCCAAGCCATCTGGTAAAATTACAATCATATCGCAACATATATTGCAAAAAAATAAAAGATAAACAATTTCACAATGTCAGATTTGTAATCTACTGGAAAAGGCTAGATGGTTATCAGGCTGCTACGCAACTACTATTGCTTGTAAGGT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| cdh1tx230/tx230 | Homozygous | ♀+/- ♂+/- | 3 figures  from 3 publications | Fig. 4 from Kane et al., 2005 | |
| cdh1tx230/+ (AB) | Heterozygous | Unknown |
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Supplemental Information
- Genotyping protocol
- None
- Grimaldi, C., Schumacher, I., Boquet-Pujadas, A., Tarbashevich, K., Vos, B.E., Bandemer, J., Schick, J., Aalto, A., Olivo-Marin, J.C., Betz, T., Raz, E. (2020) E-cadherin focuses protrusion formation at the front of migrating cells by impeding actin flow. Nature communications. 11:5397
- Colak-Champollion, T., Lan, L., Jadhav, A.R., Yamaguchi, N., Venkiteswaran, G., Patel, H., Cammer, M., Meier-Schellersheim, M., Knaut, H. (2019) Cadherin-Mediated Cell Coupling Coordinates Chemokine Sensing across Collectively Migrating Cells. Current biology : CB. 29:2570-2579.e7
- Yamaguchi, N., Colak-Champollion, T., Knaut, H. (2019) zGrad is a nanobody-based degron system that inactivates proteins in zebrafish. eLIFE. 8:
- Warga, R.M., Kane, D.A. (2018) Probing Cadherin Interactions in Zebrafish with E- and N-Cadherin Missense Mutants. Genetics. 210(4):1391-1409
- Arboleda-Estudillo, Y., Krieg, M., Stühmer, J., Licata, N.A., Muller, D.J., and Heisenberg, C.P. (2010) Movement Directionality in Collective Migration of Germ Layer Progenitors. Current biology : CB. 20(2):161-169
- Carvalho, L., Stühmer, J., Bois, J.S., Kalaidzidis, Y., Lecaudey, V., Heisenberg, C.P. (2009) Control of convergent yolk syncytial layer nuclear movement in zebrafish. Development (Cambridge, England). 136(8):1305-1315
- Kane, D.A., McFarland, K.N., and Warga, R.M. (2005) Mutations in half baked/E-cadherin block cell behaviors that are necessary for teleost epiboly. Development (Cambridge, England). 132(5):1105-1116
- McFarland, K.N., Warga, R.M., and Kane, D.A. (2005) Genetic locus half baked is necessary for morphogenesis of the ectoderm. Developmental Dynamics : an official publication of the American Association of Anatomists. 233(2):390-406
- Shimizu, T., Yabe, T., Muraoka, O., Yonemura, S., Aramaki, S., Hatta, K., Bae, Y.K., Nojima, H., and Hibi, M. (2005) E-cadherin is required for gastrulation cell movements in zebrafish. Mechanisms of Development. 122(6):747-763
- Haffter, P., Granato, M., Brand, M., Mullins, M.C., Hammerschmidt, M., Kane, D.A., Odenthal, J., van Eeden, F.J., Jiang, Y.J., Heisenberg, C.P., Kelsh, R.N., Furutani-Seiki, M., Vogelsang, E., Beuchle, D., Schach, U., Fabian, C., and Nüsslein-Volhard, C. (1996) The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development (Cambridge, England). 123:1-36
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