Genomic Feature
tm26
- ID
- ZDB-ALT-980203-1130
- Name
- tm26
- Synonyms
-
- M026B (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
- European Zebrafish Resource Center (EZRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 12: 27462703 (GRCz11) (1) Details
- Nucleotide change
- G/A
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- G>A (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation: Trp>Stop at position 87 (1)
- Flanking Sequence
-
AGGAGGAGGGATCGCTTGTCAGGAATGTCTCCGAGCTGTGAAAAGAGTGTGTAGAGCTGCGAGTGGATGTAGTGGGTCAGCCTGCACACCAAATGAGAGACTGAGAGCTGATGTGTTATGCCAAGGAAAGGCCGCATCAGGAAGGTCTTTGATTTCCTAGTTGTTCTGCAAAGGAGGCACATGCTGAAGTGGATATTTCCCAACAAGCTGCATCCTTGAGGACTCCACTAATTCTTCAGTATGGAACAGTCAGCCAGCAGTTGCATGCGGAGCCCTCATACGGGTGGCGCTTTATGGGGATGCGTCAGGAGTCCTCATTCGGGTGGCTCCGGAGCCGGGATTCAGCCTTACCAGCAGGCCCCGTTTGCTCTGCACCAGAAGCATGACTTCCTGGCCTACACAGACTTCTCCAGCTCCTGCCTGGTGCCAGCGCCACATGCGTACCCTCGGGAGGACAGACTCTATCCGGAGACGCACAGCGGGTACCAGAGGACAGAGTG
G/A CAGTTCTCTCCATGCGAGCCCAGAGGCAGAGGGCAAGAGCCCTGCCAGGGGGCGGCTGAGGCAGTGGGAGCTGAAATGGACAGTGCAGGGGGAGACAGGCTGGCTGGAGCAGTCACTGGGTGTCTCGAGGGAGACTATTCACCTCAAAGTGTGCCTGCAGTCGACACTGAAAAAAAAAGCTCCAAGCGGAAAAGAGAAGTCACAGGTGAGTCACTGTAGGCAAGAACAAATGAGATATGATGACTGGAGGTATTCAGTCATAGTCATGTGGTTGTTTTTTTTTTTTTTGAGAAATGTGCAAGTTACTTGATATCAAAAATAACATTAGTTGGTTTGAGTAGATCTGGTTGAGAACATCCTTGCTGAGGTTATAGTGAGAATGGTCAATGTTTATTCAAAAAGATTGATGTCATTTCAAACCTGAATGATATTTTTTTTTCTGCAGAGCATTCAATTCTATCAGTCATTAATATTTCTCTATATATTTAAAGTCAATGGGG - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| meox1tm26/tm26 | Homozygous | ♀+/- ♂+/- | 17 figures  from 7 publications | 11 figures from 2 publications | |
| meox1tm26/tm26 (TU) | Homozygous | ♀+/- ♂+/- | 6 figures from Dauer et al., 2018 | ||
| meox1tm26/tm26; ci5Tg; y1Tg | Complex | Fig. S5 from Nguyen et al., 2014 | Fig. S5 from Nguyen et al., 2014 | ||
| meox1tm26/tm26; y1Tg | Complex | Fig. S5 from Nguyen et al., 2014 | Fig. S5 from Nguyen et al., 2014 | ||
| meox1tm26/tm26; zf13Tg | Complex | 2 figures from Nguyen et al., 2014 | 2 figures from Nguyen et al., 2014 | ||
| meox1tm26/tm26 + MO2-cxcl12a | Complex | Fig. 10 from Svetic et al., 2007 | |||
| meox1tm26/tm26; mitfaw2/w2 | Complex | Fig. 3 from Svetic et al., 2007 | Fig. 3 from Svetic et al., 2007 |
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Supplemental Information
- Genotyping protocol
- None
- Dauer, M.V.P., Currie, P.D., Berger, J. (2018) Skeletal malformations of Meox1-deficient zebrafish resemble human Klippel-Feil syndrome. Journal of anatomy. 233(6):687-695
- Volkening, A., Sandstede, B. (2018) Iridophores as a source of robustness in zebrafish stripes and variability in Danio patterns. Nature communications. 9:3231
- Nguyen, P.D., Gurevich, D.B., Sonntag, C., Hersey, L., Alaei, S., Nim, H.T., Siegel, A., Hall, T.E., Rossello, F.J., Boyd, S.E., Polo, J.M., Currie, P.D. (2017) Muscle Stem Cells Undergo Extensive Clonal Drift during Tissue Growth via Meox1-Mediated Induction of G2 Cell-Cycle Arrest. Cell Stem Cell. 21:107-119.e6
- Hiscock, T.W., Megason, S.G. (2015) Mathematically guided approaches to distinguish models of periodic patterning. Development (Cambridge, England). 142:409-19
- Nguyen, P.D., Hollway, G.E., Sonntag, C., Miles, L.B., Hall, T.E., Berger, S., Fernandez, K.J., Gurevich, D.B., Cole, N.J., Alaei, S., Ramialison, M., Sutherland, R.L., Polo, J.M., Lieschke, G.J., Currie, P.D. (2014) Haematopoietic stem cell induction by somite-derived endothelial cells controlled by meox1. Nature. 512(7514):314-8
- Frohnhöfer, H.G., Krauss, J., Maischein, H.M., and Nüsslein-Volhard, C. (2013) Iridophores and their interactions with other chromatophores are required for stripe formation in zebrafish. Development (Cambridge, England). 140(14):2997-3007
- Svetic, V., Hollway, G.E., Elworthy, S., Chipperfield, T.R., Davison, C., Adams, R.J., Eisen, J.S., Ingham, P.W., Currie, P.D., and Kelsh, R.N. (2007) Sdf1a patterns zebrafish melanophores and links the somite and melanophore pattern defects in choker mutants. Development (Cambridge, England). 134(5):1011-1022
- Odenthal, J., van Eeden, F.J., Haffter, P., Ingham, P.W., and Nüsslein-Volhard, C. (2000) Two distinct cell populations in the floor plate of the zebrafish are induced by different pathways. Developmental Biology. 219(2):350-363
- Brand, M., Heisenberg, C.P., Warga, R.M., Pelegri, F., Karlstrom, R.O., Beuchle, D., Picker, A., Jiang, Y.J., Furutani-Seiki, M., van Eeden, F.J., Granato, M., Haffter, P., Hammerschmidt, M., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., and Nüsslein-Volhard, C. (1996) Mutations affecting development of the midline and general body shape during zebrafish embryogenesis. Development (Cambridge, England). 123:129-142
- Haffter, P., Granato, M., Brand, M., Mullins, M.C., Hammerschmidt, M., Kane, D.A., Odenthal, J., van Eeden, F.J., Jiang, Y.J., Heisenberg, C.P., Kelsh, R.N., Furutani-Seiki, M., Vogelsang, E., Beuchle, D., Schach, U., Fabian, C., and Nüsslein-Volhard, C. (1996) The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development (Cambridge, England). 123:1-36
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