Genomic Feature
rdb2
- ID
- ZDB-ALT-230726-37
- Name
- rdb2
- Synonyms
-
- c.89_95del; c.99_100insAAG (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one delins (1)
- Protocol
- embryos treated with
- Lab of Origin
- Department of Organismal Animal Physiology
- Current Source
- Other Pages
-
Notes
No data available
Variants
- Variant Type
- Delins
- Variant Location
- Chr 1: 26702832 - 26702842 (GRCz11) (1) Details
- Nucleotide change
- CTTCCTCCGAC/CTTCTTCC
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 8 bp inserted / 11 bp deleted in Exon 1 (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
CTTGACTGACCCGCTGTGAAGTTTGGAGAGGAGGACTGGTAGTAAGCAGAAGGAAGCTGTTGTGCGTATGGCGGACTCACAGCCATGTTGGAGTAGACGGAGTTGGCGTAGGCTGAGCGCGCAATCTGGACCGGTGAGAAAACGGGAGATTCGTGCACATATGATGAATATGTAGTGAAGTCGCTGCGCTTGAACCGCTTTCGACGTCGTAGGAAGCTTCCACTTTCAAACATGTCTTCGGCGTTAGGGTCAAGAGCCCAGTAGTTGCCTTTTCCGGGCCTACCGGGCTCTCGTGGGATCTTGATAAAGCAGTCGTTGAGTGTCAAATTATGGCGGATGGAGTTCTGCCATTTCTTGGAGTTGTCTCGATAGAAGGGAAACCTCTCGGTGATAAACTTGTAGATCCCTCCCAGAGTGAGTTTGCGGTCAGGCGAGTTAGCGATGGCCATGGAGATCAGAGCGATGTAGCTGTATGGTGGTTTGCCTCGCTGAAGGGGCCT
CTTCCTCCGAC/CTTCTTCC GGCCTCTTTGCGGCTCTGCTCTCTGACTGTCATTCACTGGAAGAGTGGTTTCAGAGGGAGAATCACTCTCCACTTTAACCACAGGCATGACTCTAGTTAGAATCGCTCCCAAAGGTAGCACAGCTTGGAAATCACTATAGTCTGACTGTCACTGATTCGGTTCACCGGGTTCTTTGTCAGGAGCAGCAAATGGTCTTTGCTTGCTGAATGTATTCTGGTGAAAAAGTACCAGTCATAATGCAGACCTTAAAATCCCCAAGCAGAAAGATCTGTTCCTTTGATCTTCATCTGTATCGTTAAGTGTATCCTTACACCACAGTGTCCTTAATTCAGAGGAGTTCATGCAAAACTAAGTGAACATAAAAAATGGAAGCACTCACATAAACAGTCTTTTTTGGTAGTGGTCTTCGTAATGTGGAAGAGACAAGTGAGCAGTCAATAACTGACTGTGCTGACCAAGGAACACACTACCTGAAGAGTTATTAGCCACACCTCTTCAA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| foxe1rdb2/rdb2 (AB) | Homozygous | ♀+/- ♂+/- | 3 figures  from Raterman et al., 2023 | 4 figures from Raterman et al., 2023 | |
| foxe1rdb2/+ (AB) | Heterozygous | ♀+/- ♂+/- | 2 figures from Raterman et al., 2023 | ||
| foxe1rdb2/rdb2; hu5910Tg (AB) | Complex | FIGURE 7 from Raterman et al., 2023 |
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Supplemental Information
- Genotyping protocol
- None
- Raterman, S.T., Wagener, F.A.D.T.G., Zethof, J., Cuijpers, V., Klaren, P.H.M., Metz, J.R., Von den Hoff, J.W. (2024) foxe1 mutant zebrafish show indications of a hypothyroid phenotype and increased sensitivity to ethanol for craniofacial malformations. Developmental Dynamics : an official publication of the American Association of Anatomists. :
- Raterman, S.T., Von Den Hoff, J.W., Dijkstra, S., De Vriend, C., Te Morsche, T., Broekman, S., Zethof, J., De Vrieze, E., Wagener, F.A.D.T.G., Metz, J.R. (2023) Disruption of the foxe1 gene in zebrafish reveals conserved functions in development of the craniofacial skeleton and the thyroid. Frontiers in cell and developmental biology. 11:11438441143844
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