Gene
foxe1
- ID
- ZDB-GENE-061116-1
- Name
- forkhead box E1
- Symbol
- foxe1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including neural crest cell migration; regulation of bone development; and skeletal system morphogenesis. Predicted to be located in nucleus. Is expressed in several structures, including endocrine system; head; keratinocyte; notochord; and pharynx. Human ortholog(s) of this gene implicated in Bamforth-Lazarus syndrome and papillary thyroid carcinoma. Orthologous to human FOXE1 (forkhead box E1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-foxe1 | Raterman et al., 2023 | |
| MO1-foxe1 | N/A | Nakada et al., 2009 |
| MO2-foxe1 | N/A | Nakada et al., 2009 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Bamforth-Lazarus syndrome | Alliance | Bamforth-Lazarus syndrome | 241850 |
| {Thyroid cancer, nonmedullary, 4} | 616534 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018122 | Fork head domain conserved site1 |
| Conserved_site | IPR030456 | Fork head domain conserved site 2 |
| Domain | IPR001766 | Fork head domain |
| Family | IPR050211 | Forkhead box domain-containing protein |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Forkhead box domain-containing protein | Fork head domain | Fork head domain conserved site1 | Fork head domain conserved site 2 | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2B6T0 | InterPro | 354 |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-foxe1 | polyclonal | IgG | Rabbit |
|
Boster Biological
|
2 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-25O16 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_005159910 (1) | 1438 nt | ||
| Genomic | GenBank:BX005000 (1) | 194243 nt | ||
| Polypeptide | UniProtKB:A0A8M2B6T0 (1) | 354 aa |
- Fang, Y., Wan, J.P., Wang, Z., Song, S.Y., Zhang, C.X., Yang, L., Zhang, Q.Y., Yan, C.Y., Wu, F.Y., Lu, S.Y., Sun, F., Han, B., Zhao, S.X., Dong, M., Song, H.D. (2024) Deficiency of the HGF/Met pathway leads to thyroid dysgenesis by impeding late thyroid expansion. Nature communications. 15:31653165
- Raterman, S.T., Von Den Hoff, J.W., Dijkstra, S., De Vriend, C., Te Morsche, T., Broekman, S., Zethof, J., De Vrieze, E., Wagener, F.A.D.T.G., Metz, J.R. (2023) Disruption of the foxe1 gene in zebrafish reveals conserved functions in development of the craniofacial skeleton and the thyroid. Frontiers in cell and developmental biology. 11:11438441143844
- Zeng, C.W., Sheu, J.C., Tsai, H.J. (2020) A new member of the forkhead box protein family in zebrafish: Domain composition, phylogenetic implication and embryonic expression pattern. Gene expression patterns : GEP. 35:119093
- Lidral, A.C., Liu, H., Bullard, S.A., Bonde, G., Machida, J., Visel, A., Moreno Uribe, L.M., Li, X., Amendt, B., Cornell, R.A. (2015) A Single Nucleotide Polymorphism Associated with Isolated Cleft Lip and Palate, Thyroid Cancer and Hypothyroidism Alters the Activity of an Oral Epithelium and Thyroid Enhancer Near FOXE1. Human molecular genetics. 24(14):3895-907
- Opitz, R., Maquet, E., Zoenen, M., Dadhich, R., and Costagliola, S. (2011) TSH Receptor Function Is Required for Normal Thyroid Differentiation in Zebrafish. Molecular endocrinology (Baltimore, Md.). 25(9):1579-99
- Nakada, C., Iida, A., Tabata, Y., and Watanabe, S. (2009) Forkhead transcription factor foxe1 regulates chondrogenesis in zebrafish. Journal of experimental zoology. Part B, Molecular and developmental evolution. 312(8):827-840
- Yaklichkin, S., Vekker, A., Stayrook, S., Lewis, M., and Kessler, D.S. (2007) Prevalence of the EH1 Groucho interaction motif in the metazoan Fox family of transcriptional regulators. BMC Genomics. 8(1):201
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