Genomic Feature
b1403
- ID
- ZDB-ALT-230130-7
- Name
- b1403
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Grimes Lab
- Current Source
- Other Pages
-
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 18: 46386824 - 46386829 (GRCz11) (1) Details
- Nucleotide change
- ATCGCC/-
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 6 bp deleted in Exon 5 (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
AAAGACTTCTCCCAAAACTATACTACTTCTAAACTAAATAGCTAAGTGAAATGCATTTGAATGATTTTCTGGCTAAGAACAGGACATCTAATATCACAAATGCCCACTGGGTGGCAGCAAAGGGAAACACCGCTGTGTTTATACATCAAAGGCATGGTAATTAAGTATGGAAATTACACAGTGAAGCTTAAAGATCTGAAATAAATTAATGTGGTTAAGTGCTTCCCCCTCCCGAGTATTTGTCCTCTCTGTCTTCATCTACAGGCACTTCAGGCTCACATCTTGCCCCTGACGAATGTAGCCTTCAATAAATCAGGATCTTGGTGAGTTTATCAGCTGCGCTCACATGCCTCCCTCTCTCCGATCCTCCCTCTCCCCTTCACTTTCCGTCTGTTTGCAGCTTTATAACCGGAAGCTATGACAGGACCTGTAAAATATGGGACACTGCATCCGGAGAGGAGCTGCACACTTTGGAGGGTCACAGGAACGTTGTGTATGCC
ATCGCC/- TTCAACAACCCTTACGGGTAACAGCACCGCTCTCGCTCATTTCATCACGTATGTCCTGAAACACTCAGAACAGCTCTTTTTTGGGGATGAAATAGAAAGCAAACAACCATCTCTGTCTGATTCTGCAGGGTTAGGGCACTGCAGGGTAACTGGTGTTGTTATTACAATGGGACCATTTGTCACTTTGAGTCATAACAGGAGCACTTGTCCCTTTTTTCTTCTTCTCTGCCCTCTTTCTCACTGTCTCTCGCTCTCAGAGACAAGGTTGCCACAGGCTCCTTTGACAAGACCTGCAAATTGTGGAGTGCTGAAACAGGAAAGTGTTTCTACACGTTTAGAGGGCACACGGCAGAAATCGTACGTCTGGTTTTCACTTCACATCACCTAAAAACCAGCATCACTGTCAGCTGTTTAACAAGCAGCTCACCTAAAATGTTCAATTCTCTCCTCATATTTACACCCCTATGCTGCTTCTTTAACCCTGTATGACTTTCTTTAGC - Additional Sequence
- None
Fish
Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
---|---|---|---|---|---|
daw1b1403/b1403 (AB) | Homozygous | ♀+/- ♂+/- | 4 figures from 2 publications | Fig. 2 from Leslie et al., 2022 |
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Supplemental Information
- Genotyping protocol
- None
- Bearce, E.A., Irons, Z.H., Craig, S.B., Kuhns, C.J., Sabazali, C., Farnsworth, D.R., Miller, A.C., Grimes, D.T. (2022) Daw1 regulates the timely onset of cilia motility during development. Development (Cambridge, England). 149(12)
- Leslie, J.S., Hjeij, R., Vivante, A., Bearce, E.A., Dyer, L., Wang, J., Rawlins, L., Kennedy, J., Ubeyratna, N., Fasham, J., Irons, Z.H., Craig, S.B., Koenig, J., George, S., Pode-Shakked, B., Bolkier, Y., Barel, O., Mane, S., Frederiksen, K.K., Wenger, O., Scott, E., Cross, H.E., Lorentzen, E., Norris, D.P., Anikster, Y., Omran, H., Grimes, D.T., Crosby, A.H., Baple, E.L. (2022) Biallelic DAW1 variants cause a motile ciliopathy characterized by laterality defects and subtle ciliary beating abnormalities. Genetics in medicine : official journal of the American College of Medical Genetics. 24(11):2249-2261
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