Genomic Feature
ibl54
- ID
- ZDB-ALT-220331-16
- Name
- ibl54
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Spaink Lab
- Current Source
- Other Pages
-
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 4: 19032042 - 19032048 (GRCz11) (1) Details
- Nucleotide change
- TAGAGGG/-
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 7 bp deleted in Exon 2 (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
AACAAGAAAAGACAGTATAGGCCACTGATTTTTGTAAACATAATTTATTTTAAAAATCTTAAAAAAACAAAAGTGCATACAATCTTTACAATCCTTCTTCTTACAGTATATAACACATATTATAACACAATCCACAACTACAGGCAAGTTGGAATTATCAGTGCTATGTTGTAATATCAAAAATATAGCTTAGAAAATAGAAAGCTGCAGCACTAACATAAAAACTGAGAACTAAACAAGTGAAATAAGTTAAATAATTTAGAGAACTAGTCCTTGCATGTGCCATTGTGTTTTAAAAGTGATGCATAGAAGTAACAATGCATGGCTTACACATTTCAGAGAATGAATGTCTCAGCCACATCTGTATCTTTGCAGTATTTCAGTTTGTCTATGTTGAGGCAGAGCTTCTCCAGGAACCTCTGGAGCTCCAGGAGGTGCAGGTAGTTGGAGGTGACGGGGAAGGCTGTTTCTTCTTTATGCACCGGGGTCTCGGGATTGGG
TAGAGGG/- CATCCCTGTGAGACGGCCAGTTCCTCCAGTGTCCTCAGGAGAGTCTCTAAGTCTATCTGGACCTGCTGTAGGTGCTGAGCTGGAGGAACATGCAACCGCAACTGCAGGTAACTCAAGTAACTCAAGACAGAACTGAGACCATCAATGGGGTTGTCGATGTCAGGGCCGAAATCAATCTCTGGAGACATCTGGAAGTGCTAGAGAGATATGCAGATGTTACTGATTGTAATTGTTATGTGTTTTTATATGTAGTTGACGTTCAAACTATTAGTGGAATTTAGTCATTGATCATTCTGCTGTGGTGACTCTTGATAAATCAAGAACTAAGCTGATGGAAAATGAATGAATGAATAAAAAATGTATCATTTAATTAGAAAGGCCAAGAACCAAGAGCCTTTTTTCCCAACATTTTTAAACAACATAGTTTTAAAAACTAATTAGTTTTTGCCATAGAGTTAAAACATATTTTTTTTTTACCTGTTATTTTAGTAGTTATTTAT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| lepbibl54/ibl54 | Homozygous | ♀+/- ♂+/- | 4 figures  from Ding et al., 2022 | ||
| lepbibl54/ibl54 (AB/TL) | Homozygous | ♀+/- ♂+/- | 9 figures from 3 publications |
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Supplemental Information
- Genotyping protocol
- None
- Eeza, M.N.H., Singer, R., Ding, Y., He, J., Zuberi, Z., Baelde, H.J., de Groot, H.J.M., Matysik, J., Spaink, H.P., Alia, A. (2023) Probing microstructural changes in muscles of leptin-deficient zebrafish by non-invasive ex-vivo magnetic resonance microimaging. PLoS One. 18:e0284215e0284215
- Ding, Y., Haks, M.C., van den Eeden, S.J.F., Ottenhoff, T.H.M., Harms, A.C., Hankemeier, T., Eeza, M.N.H., Matysik, J., Alia, A., Spaink, H.P. (2022) Leptin mutation and mycobacterial infection lead non-synergistically to a similar metabolic syndrome. Metabolomics : Official journal of the Metabolomic Society. 18:67
- Ding, Y., Haks, M.C., Forn-Cuní, G., He, J., Nowik, N., Harms, A.C., Hankemeier, T., Eeza, M.N.H., Matysik, J., Alia, A., Spaink, H.P. (2021) Metabolomic and transcriptomic profiling of adult mice and larval zebrafish leptin mutants reveal a common pattern of changes in metabolites and signaling pathways. Cell & Bioscience. 11:126
- He, J., Ding, Y., Nowik, N., Jager, C., H Eeza, M.N., Alia, A., Baelde, H.J., Spaink, H.P. (2021) Leptin deficiency affects glucose homeostasis and results in adiposity in zebrafish. The Journal of endocrinology. 249(2):125-134
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