Genomic Feature
waw301
- ID
- ZDB-ALT-210219-18
- Name
- waw301
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one insertion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Laboratory of Neurodegeneration (Kuznicki Laboratory)
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Insertion
- Variant Location
- Chr 7: 62409420 - 62409421 (GRCz11) (1) Details
- Nucleotide change
- -/AGAT
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 4 bp inserted in Exon 3 (1)
- Transcript Consequence
- Frameshift, Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
TTTAGGCATGCATGTGCACTGAGCAAACACACATGCAAAACCACAGAGCGATAAAGAGTTGACACAGACATGGCCATAGAGAGCTTCACACTTATCTAGAGCGCTTGTCATGTTCTAACAGCTTTATTGCACAATAAATTCTCCTCTAGTCATGCATTCTTCAGCCTACTTTTTTAAAACTGTATCGTTGTATTCACATGTTGTTCACTCATTATGACTAATCACTTTGCTTTGCTTATAAGCATCTGCTGAAATATGACACATATGGCAAAAGATCTGATAGTATTTGTTGCATTAAAAATATTTGCATAATTTTGAAAAGTATATTTGAAAGCATCGGATGCTCTGATAGAGTCACTTGTACCATGAAGCCAGTCATTTTCCTGTGGTTTGAGCATTAATGTTATGCTGTGGTTCTTCTGCAGTTTATCATAGAGGACATGAAGCAGCACCAGACCAATAAACACAGTAATCTCCACCGAGAGGACCAGCACATCACGG
-/AGAT TGGAGGAGCTATGGAGGGGCTGGAAAATATCAGAAGGTAAAGACTTAATGTGTAGAGATGCTGCGGTTTATACCACAATAGATGAATTTTACATAGAAGGACAGATTCATTATTAACAAGCAAACAATTGAAAGGTGAAATTGTTTGAAATTACTGAGCAGCATGCATCCAAAGCTAGTATACACATGAAAGTTCTTTAAGTATTGAATTAAATTCATTAAAGGGAAAGTTTACACAAAATTAAACTTGAGGTTGGGATTTGAATAAATGTTTACGTAAGTTAATGTTTTCACTTCCTTTTTTACCTACACCCACTGCATTTTAAAAATTAAAAAAAATAAAATAAAATCAAAATTAAATAGCAAATCAAATCGAAGTCGATATCGCAACATCTGTTAAAAAATTGCAACAAGATATTTCCCCAAATCACACAGCCCTAGTTTTATTTTCAATCTACTTAAATCAGTTATGTTAACATAATGTATTTGTGTTGGGACAATA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| stim2bwaw301/waw301 (AB) | Homozygous | ♀+/- ♂+/- | 5 figures from Wasilewska et al., 2020 | 2 figures from Wasilewska et al., 2020 | |
| stim2bwaw301/waw301; a4598Tg (AB) | Complex | Fig. 2 from Wasilewska et al., 2020 | |||
| stim2awaw303/waw303; stim2bwaw301/waw301 (AB) | Complex | 4 figures  from Baranykova et al., 2024 |
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Supplemental Information
- Genotyping protocol
- None
- Baranykova, S., Gupta, R.K., Kajdasz, A., Wasilewska, I., Macias, M., Szybinska, A., Węgierski, T., Nahia, K.A., Mondal, S.S., Winata, C.L., Kuźnicki, J., Majewski, L. (2024) Loss of Stim2 in zebrafish induces glaucoma-like phenotype. Scientific Reports. 14:2444224442
- Wasilewska, I., Majewski, Ł., Adamek-Urbańska, D., Mondal, S.S., Baranykova, S., Gupta, R.K., Bielecki, D., Winata, C.L., Kuznicki, J. (2023) Lack of Stim2 Affects Vision-Dependent Behavior and Sensitivity to Hypoxia. Zebrafish. 20:146159146-159
- Wasilewska, I., Gupta, R.K., Wojtaś, B., Palchevska, O., Kuźnicki, J. (2020) stim2b Knockout Induces Hyperactivity and Susceptibility to Seizures in Zebrafish Larvae. Cells. 9(5):
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