Genomic Feature
tpl137
- ID
- ZDB-ALT-190411-7
- Name
- tpl137
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Balciunas Lab Temple
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 7: 30333250 - 30333733 (GRCz11) (1) Details
- Nucleotide change
- GTGCGCCTTGGTTTGGTGGGCTACATCCAGCCACTAATGTCCAGCAGTTTAGGAAGTGAGACTCATTTACATGCAGGTATGCCTCTTCAAAACTCAAGATTTTTCTTTCTTTGGTTCAGACGCAGCTCTAAAAGCTCCCTGAAGGTCTTTGATGTGAAGTGACAGTCTGAAGCAGCACCTGTGCACAAACTGTTGCAGCGGGACAACAGGAGGCCAGCCGTAAAACAGTGTCTGAATACTTACAATCAGCATCTGCAAAAATGATGTTGGGACTCTTTCCCCCGAGCTCCAGCGTGACTCTCTTCAGATTGCTCTTTCCTGCTGCTTCTTGGATCAGCTTGCCTACCTGTGGAGACAGAGACGAGGAGCCTTAATCACAGCAGAGGAGCCTTACTAAATCTCCCTATCTGTGGGACGCTGTCATTAATAAATCGTCCCCTGCTCTTTGACTGGACAACCAGCAGCATTATCAGACCCCTGAGCT/-
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- Flanking Sequence
-
TTTTATGACTGAACATTAGAGTTATTCAATCAAAATCATATTCTGAAGTTAGAACAGTGGTACTTTATGTTTAGTGTCTCTTTTATGTCTTTAGACTCTTTAAAAATGAAAATAAACATGACACATTTTGTTATTTTAAGCAAAAAAGAAAACCTCTAAATGACAAATAAACAAGAAAAAATAAAACACAGGTGATAATTAGGAAACATCCTCAAAAATGCCTTCTAAAATAATTGATGAATAGTTTTGGAGCCATTGAATTCTGCTTAGGCATTTGTAATACGTTTTTCTATGGTGCGTCTGCTGTTTATGCACAGATCCATGCTTATGTGTACATCTGGGTGAGATAACAGACACCTGGGAAAAGGCTGGACTGGCAGACTTTGGCATTTGACGGGTTAATGGAGCAGGCAGATTTACGGTTCTAGTGAGATGTGGTTCATTCAGCTGATTTATGGGGGGCTGTGCTTGCGGCTGCTGAAAGCATTTAAAGCACTGAC
GTGCGCCTTGGTTTGGTGGGCTACATCCAGCCACTAATGTCCAGCAGTTTAGGAAGTGAGACTCATTTACATGCAGGTATGCCTCTTCAAAACTCAAGATTTTTCTTTCTTTGGTTCAGACGCAGCTCTAAAAGCTCCCTGAAGGTCTTTGATGTGAAGTGACAGTCTGAAGCAGCACCTGTGCACAAACTGTTGCAGCGGGACAACAGGAGGCCAGCCGTAAAACAGTGTCTGAATACTTACAATCAGCATCTGCAAAAATGATGTTGGGACTCTTTCCCCCGAGCTCCAGCGTGACTCTCTTCAGATTGCTCTTTCCTGCTGCTTCTTGGATCAGCTTGCCTACCTGTGGAGACAGAGACGAGGAGCCTTAATCACAGCAGAGGAGCCTTACTAAATCTCCCTATCTGTGGGACGCTGTCATTAATAAATCGTCCCCTGCTCTTTGACTGGACAACCAGCAGCATTATCAGACCCCTGAGCT/- TCAGCCCACATCTTAAATTTCTATTAGTGCTCGCGGAGGATGGAATGTCCCGCACGCAACAGTATCTGCTGGCTAATGGA ... - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| aldh1a2tpl137/+; aldh1a2tpl138/+ | Complex | Fig. 4  from Burg et al., 2018 | Fig. 4 from Burg et al., 2018 |
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Supplemental Information
- Genotyping protocol
- None
- Jiang, Z., El-Brolosy, M.A., Serobyan, V., Welker, J.M., Retzer, N., Dooley, C.M., Jakutis, G., Juan, T., Fukuda, N., Maischein, H.M., Balciunas, D., Stainier, D.Y.R. (2022) Parental mutations influence wild-type offspring via transcriptional adaptation. Science advances. 8:eabj2029
- Burg, L., Palmer, N., Kikhi, K., Miroshnik, E.S., Rueckert, H., Gaddy, E., MacPherson Cunningham, C., Mattonet, K., Lai, S.L., Marín-Juez, R., Waring, R.B., Stainier, D.Y.R., Balciunas, D. (2018) Conditional mutagenesis by oligonucleotide-mediated integration of loxP sites in zebrafish. PLoS Genetics. 14:e1007754
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