Genomic Feature
hu11872
- ID
- ZDB-ALT-190307-6
- Name
- hu11872
- Synonyms
-
- Kcnj8_ZF.V65M (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- embryos treated with
- Lab of Origin
- Bakkers Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 4: 14717694 (GRCz11) (1) Details
- Nucleotide change
- G/A
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- G>A (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
TTCAAGCGCTCTTCTGTCCGATGTGAGTGTCAGTCGGAGGCTGTAGGACAGGGATGTACCGCCCATGAGTCCAGTAGAGCAGCCCGATCTCCATCAGAAACACACATTCAGAAGCGCTTCAAACACTCACTTCTGCTCTTTTCCAGCCTTTATTCTAGAAACTGGCCCAAGAACACGGATTAAACTATTTATTGTGATCAAATCACTTTTTTTCTTATAGTTTATGCTACTTCGCCAAGTTAAACCGTGGATGCGGGATGGTTATTAAGCGCGTTTGACACGCTCAGGAGAAGTTTTTGTTGTAAATCATGTTGCCGCGGAAGAGCATCATCCCGGAGGAGTTCGCGCTGCCGGCGCTGGTGTCCCGGGTGCCGCGTAAACCAGTGTTCAGAGACCGCGTGAATAAAGCGCGCTTCATCGCCAAGAGCGGCGCGTGTAACTTGGCGCACAAGAACATCCGTGAGCAGGGCCGGTTCCTGCAGGACGTCTTCACCACTCTG
G/A TGGATCTGAAGTGGCGCTTCACGCTGGTCATCTTCACCATGACATTTCTGTGCAGCTGGCTGCTGTTCGCCATGAGCTGGTGGCTGGTGGCCTTCGGGCACGGAGATCTGGACACCGACCGTAAACCTGCCGTGGAGCAGTGCGTCACCAATGTCAAGTGAGTGCCGTTGACTTGATTGCATGTGCAGATGTCCAAAACATGTCTATCCTCCTGTTTTGTATCTGTAGCCTATAAAACTGTTGCAAACTGATGACATATTTCATTTTATAACCTAGCCTATTTTTAAGGTATTTTATCTTCTTTTTTTTTTTAAGAAAATATACGTTTTAGGAAAATGTTTTTGTCAATACGTGGAAATATATATTTTTTATATTCAAAATAATAATTATTAAAATTATTCATTTATGGTGAATGTAATAAAAATCCAATTTAAGCAGTTTTAAAAATTATTCATAACATTGTTAAATACTTATATTAAAGGGGGAAATTACCGTCATAA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| kcnj8hu11872/hu11872 | Homozygous | ♀+/- ♂+/- | 3 figures  from Tessadori et al., 2018 | ||
| kcnj8hu11872/+ | Heterozygous | ♀+/- ♂+/- | Fig. 2 from Tessadori et al., 2018 | ||
| kcnj8hu11872/hu11872; p151Tg/p151Tg | Complex | 3 figures from Singareddy et al., 2021 | |||
| kcnj8hu11872/+; la116Tg | Complex | Fig. S10 from Tessadori et al., 2018 | Fig. 2 from Tessadori et al., 2018 |
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Supplemental Information
- Genotyping protocol
- None
- Singareddy, S.S., Roessler, H.I., McClenaghan, C., Ikle, J., Tryon, R., van Haaften, G., Nichols, C.G. (2021) ATP-sensitive potassium channels in zebrafish cardiac and vascular smooth muscle. The Journal of physiology. 600(2):299-312
- Tessadori, F., Roessler, H.I., Savelberg, S.M.C., Chocron, S., Kamel, S.M., Duran, K.J., van Haelst, M.M., van Haaften, G., Bakkers, J. (2018) Effective CRISPR/Cas9-based nucleotide editing in zebrafish to model human genetic cardiovascular disorders. Disease models & mechanisms. 11(10):
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