Gene

kcnj8

ID

ZDB-GENE-060308-1

Name

potassium inwardly rectifying channel subfamily J member 8

Symbol

kcnj8 Nomenclature History

Previous Names

Kir6.1 (1)
si:dkey-183c2.2

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Predicted to have inward rectifier potassium channel activity. Predicted to be involved in potassium ion import across plasma membrane and regulation of ion transmembrane transport. Predicted to localize to integral component of membrane. Used to study hypertrichotic osteochondrodysplasia Cantu type. Orthologous to human KCNJ8 (potassium inwardly rectifying channel subfamily J member 8).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from Tessadori et al., 2018
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With kcnj8 Human Ortholog

No data available

Associated With kcnj8 Via Experimental Models

Human Disease	Fish	Conditions	Citations
hypertrichotic osteochondrodysplasia Cantu type	kcnj8^hu11872/+	standard conditions	Tessadori et al., 2018

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR040445	Potassium channel, inwardly rectifying, transmembrane domain
Domain	IPR041647	Inward rectifier potassium channel, C-terminal
Family	IPR003278	Potassium channel, inwardly rectifying, Kir6.1
Family	IPR016449	Potassium channel, inwardly rectifying, Kir
Homologous_superfamily	IPR013518	Potassium channel, inwardly rectifying, Kir, cytoplasmic
Homologous_superfamily	IPR014756	Immunoglobulin E-set