Genomic Feature
ihb332
- ID
- ZDB-ALT-190116-4
- Name
- ihb332
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Yonghua Sun Lab
- Current Source
- China Zebrafish Resource Center (CZRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 24: 8870778 - 8870797 (GRCz11) (1) Details
- Nucleotide change
- CCTGACACTGAAGACGGTAA/-
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 20 bp deleted in Exon 4 (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
AATCACTCTAAAGCCATGCATCCTACAAACCACTTGAATGTGCACAGGCAGCTGCAGACCGGTGACCAAATGTGACAAGATGTGAGAGATTATCTCATTCTCCAGTGAGAAAATATTATAGTTCAGGGTGCATATTATTACATTAGCAGCATAATAAGTGCGTGTGTCTACCAACGTGTTTCATCCCAAAGCCAAGCACATTGTTTATTGTGGTTTTAAAAAGAGAGCCATGCTTTTAGAATATTGTTTAGATAAAATTTTGTTGGAAAACATGAGTGCAATCCAGATGTAAAGAGTAGTTCAACCAGCATACCAAAAAATGTTTTTGATACAAATAATCTAGCTTGCATTTAATAGATATATGAGAGCGTCATACTTGTATCAGTACCTACAGCATCAGTATTTTCACGAGCAACAAAAATGGTCTGAGCAGCATAACGAAATAATGGGATGTGCTGTATTTCTTACCCTGATATCTGCTTCACCAACTTCGTCCAGTG
CCTGACACTGAAGACGGTAA/- CCTGCAGACCAGACTGCTGATATCAGCTACCAAACACATGAAGCACAGCATTAGGTAATCGCTTAAAGAGAACTCGACATTGGCAGATGAGCACATGGACTGCTATTGTAAGATCCAAACAAACTGTATGCTCACTTACCTCAACCAGCATGTAGAAAGACAATACAGTAACAGAGAAGTTGTACAGCAGTAAAACATTTTTCAGTGAGTATGCTGGTCTGTTTCTCATGTATTTTGTTCCCAGGTAGATTGTTAGGAGGTAGGTGATGGTGAGCAAAAATGTTGGTGTGTAGGAATCCAGCAGCAGCCATCCTCTCACGCGGGTATCTGACATCAAACAAACATGTCACTTACTCAATATGTCTGGGTAAGATCATTTTCAGGCAATCTTCTTAAATACAATACTTTCAAACTTTTTGGGAAAACTAAGTGGCCAAGGGAAAACAATCTATGCACCGAATGCATGATTATATTTTGTCATACTAACATAATTCACACGT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| elovl2ihb332/ihb332 (AB) | Homozygous | ♀+/- ♂+/- | Fig. 2 from Liu et al., 2020 | 2 figures from Liu et al., 2020 |
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Supplemental Information
- Genotyping protocol
- None
- Li, X., Liu, C., Zhang, R., Li, Y., Ye, D., Wang, H., He, M., Sun, Y. (2024) Biosynthetic deficiency of docosahexaenoic acid causes nonalcoholic fatty liver disease and ferroptosis-mediated hepatocyte injury. The Journal of biological chemistry. 300(7):107405
- Li, Y., Li, X., Ye, D., Zhang, R., Liu, C., He, M., Wang, H., Hu, W., Sun, Y. (2024) Endogenous biosynthesis of docosahexaenoic acid (DHA) regulates fish oocyte maturation by promoting pregnenolone production. Zoological research. 45:176188176-188
- Liu, C., Ye, D., Wang, H., He, M., Sun, Y. (2020) Elovl2 But Not Elovl5 Is Essential for the Biosynthesis of Docosahexaenoic Acid (DHA) in Zebrafish: Insight from a Comparative Gene Knockout Study. Marine biotechnology (New York, N.Y.). 22(5):613-619
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