Genomic Feature
s721
- ID
- ZDB-ALT-181008-4
- Name
- s721
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one insertion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Stainier Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Insertion
- Variant Location
- Chr 12: 47667576 - 47667577 (GRCz11) (1) Details
- Nucleotide change
- -/ATGAAGTAAA
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 10 bp inserted (1)
- Transcript Consequence
- Frameshift, Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
TGTGTGTCCTTCTCACTAAAGTGTGTGTCTCTCACTGATGTTTATGTCTCCCTCACTAACTTGGGTGTGTGTGTCTCACACACTGATGTGTGCCAGTCCCTCTCGGTGTGTCTGTCTGTCTCTTACTAATGTGTGTGTGTGTGTGTGTCTGTCTGTCTGACTCTCTCTTACTAATGTGTGTCTATCTCGCTGATGTTTGTGTTTCTCCCTCACTAATGTGTGTGTGTGTGTGTGTCTCTATAATGTGTGTGTGTGTGTGTGTGTGTGTCTCACTGATGTGTTTGTGTGTGTGTGTCTTACTAAGTTGTGTGTGTGTCNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGTTCGATTCTCCAACGATCAAACCATCGAGCTGGAGAAGAAGTTCGAGACGCAGAAATATCTGTCTCCGCCCGAGAGGAAGAGG
-/ATGAAGTAAA CTGGCGAAGATGCTGCAGCTCAGCGAGAGACAGGTGAGAGCCACAGCACAGCATTCAGCCTTAAAACATCATTCAGACAAAAAATTATCTCACGAATCACATCTGCTTCTGTCTGCAGGTCAAAACATGGTTCCAGAACCGCCGGGCGAAATGGAGGCGCCTGAAGCAGGTGAGAATCGCGTCTTATTTACCGTCTAGTTCGGTAATGTTCATTTGTGTCAAACATGCTTCAGTGAACCAATTTTAAATATTTAATTTTTAATTAATTAGTCAAACAAGTTTACAGTTTTTTTTATTATTTAAGGGGAAATGTCTGTCAACAGTTTCAGTATTGTGTGTTTTTCAAGTGTTTTCTGTTTATTTACAGTTGTGAATTGCATTATGGGATGTTGATCTCTGCTCTGTCGATTTTTAATGTAGAAAATTAAAGTCTACAGTTTAACAAAGTGACTTTTATTGACAATTTAATAGTTTAAAATATGATGTAGGCTTTAAGAAACA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| hhexs721/s721 | Homozygous | ♀+/- ♂+/- | 3 figures from Villasenor et al., 2019 | 2 figures  from Villasenor et al., 2019 | |
| hhexs721/s721; as3Tg | Complex | Fig. 1 from Villasenor et al., 2019 | |||
| hhexs721/s721; ci1Tg | Complex | Fig. S1 from Gauvrit et al., 2018 | |||
| hhexs721/s721; gz19Tg | Complex | Fig. S1 from Villasenor et al., 2019 | |||
| hhexs721/s721; nim5Tg | Complex | Fig. 1 from Villasenor et al., 2019 | |||
| hhexs721/s721; nz101Tg | Complex | Fig. 1 from Gauvrit et al., 2018 | |||
| hhexs721/s721; nz101Tg; s843Tg | Complex | Fig. S1 from Gauvrit et al., 2018 | |||
| hhexs721/s721; s870Tg | Complex | Fig. 2 from Villasenor et al., 2019 | |||
| hhexs721/s721; y7Tg | Complex | Fig. S1 from Gauvrit et al., 2018 |
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Supplemental Information
- Genotyping protocol
- None
- Villasenor, A., Gauvrit, S., Collins, M.M., Maischein, H.M., Stainier, D.Y.R. (2019) Hhex regulates the specification and growth of the hepatopancreatic ductal system. Developmental Biology. 458(2):228-236
- Gauvrit, S., Villasenor, A., Strilic, B., Kitchen, P., Collins, M.M., Marín-Juez, R., Guenther, S., Maischein, H.M., Fukuda, N., Canham, M.A., Brickman, J.M., Bogue, C.W., Jayaraman, P.S., Stainier, D.Y.R. (2018) HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development. Nature communications. 9:2704
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