Genomic Feature
ulb5
- ID
- ZDB-ALT-180828-1
- Name
- ulb5
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Costagliola Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 25: 31955751 - 31955761 (GRCz11) (1) Details
- Nucleotide change
- AATGAAGAGGA/-
- Variant Notes
-
c.282-293del
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 11 bp deleted from position 282 to 293 in Exon 2 (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Polypeptide Fusion (1)
- Flanking Sequence
-
CCAAAAGATGATATGTGATACACGAGAAGCATGATTGTGAAAAAATTAAGATATGTCTCTTATTTACATGTGAACAAAAACTTTTAAGTTAGCATTTGCCAGGGCTATAAATAATTCCAGGCTTGACTGTATACACTCTCAGAAATAAAGGTGCATGCGCTGTCACTGGGGCAGTACTATTTTAAAAGATGTGTACCCAAATAGTCAACAGTGCTACCTAAAAGGTCCATATTAGTACCCAAATGTACCTAAAAAGTACATTTGAGGAACCATTATGGACCCTTCAGGGACAAATATGCACCTTTTGAAAAGCTACTGCCCCAGTGACAGCTCCTGTACCTTTATTTCTGATTTAAAAAAAACATCAAGATTGGCTACATTTCACCTCATTATACAATTATTGTATCACTTTGCATATTTCTTTATCAACACAAATCTGCAGATGCCTTGTTTCTAGACTATTTGATGCAACTCACCGATCTGCCACGTATTCCCGGTAG
AATGAAGAGGA/- AACTGACAGCCAGAACCGAGAAAACCAGGATTGCGACCAGCAGGCTGATGTTGATCATGAACGGGCTCCTTTGTAGCGGGTAAAACGGGTAAATGCCATCGTAGAAAGTCATCTTCCCTCCACAGGCGAGAACTAAAGCTGAAAGCAGGACAGTGTTGGCCAGAGGCTCGGTTACCTGAAGATTGCAGATAACAGTCTGCTGGTGTGCGCGTTTTACACACTCACTTTCAGGGGATTGAAATTTGAAGGCTGATAGCTGAAATGCATCTCAACCTTATAGTTTTAGCATATGAAAATGAAGCATACCCTCATAAACTTGTTTGCTTCATGATGATTCAATGAATGTGCCCACGTTTCACTCACATTTAGGCATGGACTACTTGTAGTTTGAACACGAAAATTAAGCTTAAAGGGATAGTTCCCTCAAAATTGAAACTTTAATTTGTTCACACTCTTAAATGGTTCCCGAGTTTTACTAGTTTTCTCATAAAACTTAAAAG - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| duox2ulb5/+; ulb4Tg | Complex | Fig. 7  from Trubiroha et al., 2018 | |||
| duox2ulb5/ulb5; ulb4Tg | Complex | Fig. 7 from Trubiroha et al., 2018 | 2 figures from 2 publications |
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Supplemental Information
- Genotyping protocol
- None
- Giusti, N., Gillotay, P., Trubiroha, A., Opitz, R., Dumont, J.E., Costagliola, S., De Deken, X. (2019) Inhibition of the thyroid hormonogenic H2O2 production by Duox/DuoxA in zebrafish reveals VAS2870 as a new goitrogenic compound. Molecular and Cellular Endocrinology. 500:110635
- Trubiroha, A., Gillotay, P., Giusti, N., Gacquer, D., Libert, F., Lefort, A., Haerlingen, B., De Deken, X., Opitz, R., Costagliola, S. (2018) A Rapid CRISPR/Cas-based Mutagenesis Assay in Zebrafish for Identification of Genes Involved in Thyroid Morphogenesis and Function. Scientific Reports. 8:5647
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