Gene
duox2
- ID
- ZDB-GENE-111007-1
- Name
- dual oxidase 2
- Symbol
- duox2 Nomenclature History
- Previous Names
-
- duoxa (1)
- zmp:0000001198
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Acts upstream of or within thyroid gland development. Is expressed in brain; intestine; thyroid follicle; thyroid primordium; and ultimobranchial body. Human ortholog(s) of this gene implicated in thyroid dyshormonogenesis 5. Orthologous to several human genes including DUOXA2 (dual oxidase maturation factor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| thyroid dyshormonogenesis 5 | Alliance | Thyroid dyshormonogenesis 5 | 274900 |
1 - 1 of 1
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
| Protein | Length |
|---|---|
|
UniProtKB:E7FEH3
|
329 |
1 - 1 of 1
- Genome Browsers
- No data available
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| Genomic | GenBank:CABZ01038908 (1) | |||
| Polypeptide | UniProtKB:E7FEH3 (1) | 329 aa |
- Comparative Orthology
- Alliance
- Zasu, A., Hishima, F., Thauvin, M., Yoneyama, Y., Kitani, Y., Hakuno, F., Volovitch, M., Takahashi, S.I., Vriz, S., Rampon, C., Kamei, H. (2022) NADPH-Oxidase Derived Hydrogen Peroxide and Irs2b Facilitate Re-oxygenation-Induced Catch-Up Growth in Zebrafish Embryo. Frontiers in endocrinology. 13:929668
- Salis, P., Roux, N., Huang, D., Marcionetti, A., Mouginot, P., Reynaud, M., Salles, O., Salamin, N., Pujol, B., Parichy, D.M., Planes, S., Laudet, V. (2021) Thyroid hormones regulate the formation and environmental plasticity of white bars in clownfishes. Proceedings of the National Academy of Sciences of the United States of America. 118(23):
- Giusti, N., Gillotay, P., Trubiroha, A., Opitz, R., Dumont, J.E., Costagliola, S., De Deken, X. (2019) Inhibition of the thyroid hormonogenic H2O2 production by Duox/DuoxA in zebrafish reveals VAS2870 as a new goitrogenic compound. Molecular and Cellular Endocrinology. 500:110635
- Trubiroha, A., Gillotay, P., Giusti, N., Gacquer, D., Libert, F., Lefort, A., Haerlingen, B., De Deken, X., Opitz, R., Costagliola, S. (2018) A Rapid CRISPR/Cas-based Mutagenesis Assay in Zebrafish for Identification of Genes Involved in Thyroid Morphogenesis and Function. Scientific Reports. 8:5647
- Opitz, R., Maquet, E., Zoenen, M., Dadhich, R., and Costagliola, S. (2011) TSH Receptor Function Is Required for Normal Thyroid Differentiation in Zebrafish. Molecular endocrinology (Baltimore, Md.). 25(9):1579-99
- Flores, M.V., Crawford, K.C., Pullin, L.M., Hall, C.J., Crosier, K.E., and Crosier, P.S. (2010) Dual oxidase in the intestinal epithelium of zebrafish larvae has anti-bacterial properties. Biochemical and Biophysical Research Communications. 400(1):164-168
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