Genomic Feature
zf1031
- ID
- ZDB-ALT-180409-5
- Name
- zf1031
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 18: 39630775 - 39630805 (GRCz11) (1) Details
- Nucleotide change
- ACTGCAGACCCAGTTTACTTCCAAAGCGTGA/-
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 31 bp deleted in Exon 3 (1)
- Transcript Consequence
- Frameshift (1)
- Protein Consequence
- None
- Flanking Sequence
-
GGCTGTAGGAAAATAGGAAAAGACTCAACATTTTTATATCTTAGACAGAAAGAGGATCTACAGTAGGTCTGTTTTTTTTCTAAAGCACTGTTTGGAAGATGGTTTGAGTGGCCAAAAAAATCTCCACAAAAGTAACAGCTAAAGAATTGCAGAAGTTAATGAAGCCTTGGGGTCAGAAAGCCTCTAAAACTACAATCTAACATCAACACAAATAGTTTGAAAGGGTTTAAAAAATAAATAAATAAATTATTAAATAAATAAATAAATACATTTCTTTCTTTCTTTCGTTAATATTTTGAGCAAAAGTTCAAAAGAATAAAGAACTTATACTTTTTTATCACCGCTTTTTTGCTCACATTCACCAAAGATTCTAATATATTTTAAATATATTTATGTAATCGTATTTTATTAATGCCCACCTTTAGCATAAAATGCACGGACTTTCTTCCAGAGAGCCACATTTGAGTTGAATATGATGCCCTGCTCATGCATCCCGATGC
ACTGCAGACCCAGTTTACTTCCAAAGCGTGA/- AGTGTACAAAGACTTCCTTAACACGTGATATACAGCTGACGACCTGTGACACAAACACACATACAAAAAGCATCAGAATAATGCATTCAAGCTACATTTGGGTTCATTTGCTTTGAATTATTCTGTAATAAATATATAGTTGCAGCCAACATTATTACCCCTACTGTGAAATTGTTATTATTTTCCAAGTAGTTCCTATTATATTTTTCTTCTGGAAAAAGTCTTATTTATGTTAGTTTGGCTGGAATTTCTTACTTTTTGTTGTTGTTGTTGATTGTCTGCAGAATAAACCACTGTTGTCCAATGGATAATTACCCTGACTTGCCTAGTTAACCTAATTAACCTAGTTAACATGAAGTGAACTGAACTGAAGTGGGCTAAAATAAGTATTATTTTCATAAAAATGGTTTCATTTATCATAAATTCTTATCAGTATAGAGCTAATAGTAAAACCGTATTTGAAATGACAGCTGAGAAATTATGAAATTTCATATAATAAT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| cyp19a1azf1031/zf1031 (AB) | Homozygous | ♀+/- ♂+/- | 4 figures from Yin et al., 2017 | Fig. 7 from Yin et al., 2017 | |
| cyp19a1azf1031/+ (AB) | Heterozygous | ♀+/- ♂+/- | Fig. 2 from Yin et al., 2017 | ||
| cyp19a1azf1031/zf1031; cyp19a1bzf1032/zf1032 (AB) | Complex | 2 figures from Yin et al., 2017 |
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Supplemental Information
- Genotyping protocol
- None
- Shaw, K., Therrien, M., Lu, C., Liu, X., Trudeau, V.L. (2023) Mutation of brain aromatase disrupts spawning behavior and reproductive health in female zebrafish. Frontiers in endocrinology. 14:12251991225199
- Tang, H., Chen, Y., Liu, Y., Yin, Y., Li, G., Guo, Y., Liu, X., Lin, H. (2017) New Insights Into the Role of Estrogens in Male Fertility Based on Findings in Aromatase-Deficient Zebrafish. Endocrinology. 158:3042-3054
- Yin, Y., Tang, H., Liu, Y., Chen, Y., Li, G., Liu, X., Lin, H. (2017) Targeted disruption of aromatase reveals dual functions of cyp19a1a during sex differentiation in zebrafish. Endocrinology. 158(9):3030-3041
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