Genomic Feature
fu48
- ID
- ZDB-ALT-160413-4
- Name
- fu48
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Lecaudey Lab
- Current Source
- Other Pages
Notes
Comment | Citation |
---|---|
fu48 has a single-nucleotide deletion in yap1, resulting in a frame-shift and ... | ZFIN Staff |
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 18: 37351470 - 37351474 (GRCz11) (1) Details
- Nucleotide change
- ACGGT/-
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 5 bp deleted in Exon 2 (1)
- Transcript Consequence
- Frameshift, Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
AAAAATTGCAGTTTACACAGAGTTGATAATGGTAGCATTTTTCAAAAACCTGCCATTTTTTCAAACATTTGCACTTCAAACTGCCTTCATCATGTAAATGAACTGCCAAAATACATAAAAACTAGTCATGTAAAAAAGTGACACCTCAAAGTCTAATTGAAAGACAAGTTTCCACTTCTAAAATGACCAGCAGCATTTCAGACTTAACCCCATTCTAAAACTTACCAAAACAAATTAATCACCCCTAACCCATGATGCTGTAGTACGCGTTATATCAAGCAACATTAACAACTCACTTTAGGAAGTATCTCTGTCCCGAAGGGGTCTTGGCCATCTCCCAGCCTGGGGGCAGCGGCATGTCATCAGGTATCTCGTAAGAGGACTGGCGGAGGTGCTGAGGTGGGGCGTTTGCTGGACCCATGCTGGTCAGTGCACCAGGAGAAACTGCGCCCAGCTGCAGGGAGGCAGGTGAGGAGTGTGCCCGGACGTGATGGGGCGTG
ACGGT/- ACCAGCAGTACCTGCATCTGTACTGGCCTATACGGGGATAGAGGATTAGTTTAGCATAAAGAAAACATTTAGACTAGGATTGGATTTAAAGCAAATACCCCACAGGCAATAATTCTCTCAAACAGAGAACAGACTTATGACTAAACCTAAATAATTTGCACAATTTGCTCTCTTGCTTTACTCTCCCTCAAGTGGTTCCAAACTTTTATAAGTTTCTTGAACACAAAGTAAGTTATTTTAAATGTTAATTATGTCAGAAAGCTGTAACCACTGACCTCCATGGTATTTGTTTTTTCTACTATTGAAGTCAGTGCTTACAGGTTTTTAAAATGTCTTCTTTAATGTTAAATAGAAAGAAAAAAAATCTCAAACAGGTTTGTGATAATTAAAGAGTGAGTAAATGATGACAGAACGCTCAATTTTTGATGAAGTGTCCAATTAAAGTCAACAATTTGTTTGAAAACATTCATTTCGACTTTTTTCAACTAGTCTATGAGATT - Additional Sequence
- None
Fish
Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
---|---|---|---|---|---|
yap1fu48/fu48 | Homozygous | ♀+/- ♂+/- | Figure 5 from Duchemin et al., 2019 | ||
yap1fu48/+ | Heterozygous | ♀+/- ♂+/- | Figure 5 from Duchemin et al., 2019 | ||
yap1fu48/fu48; mw50Tg; y171Tg | Complex | ||||
yap1fu48/fu48; zf106Tg | Complex | Fig. 5 from Agarwala et al., 2015 | Fig. 5 from Agarwala et al., 2015 | ||
yap1fu48/fu48; zf106Tg | Complex | 3 figures from Agarwala et al., 2015 | 3 figures from Agarwala et al., 2015 | ||
amotl2afu46/fu46; yap1fu48/fu48; zf106Tg | Complex | Fig. 6, S1 from Agarwala et al., 2015 | 2 figures from Agarwala et al., 2015 | ||
yap1fu48/fu48; zf106Tg + MO3-lef1 | Complex | Fig. 7 from Agarwala et al., 2015 | Fig. 7 from Agarwala et al., 2015 | ||
yap1fu48/fu48; wwtr1fu55/+; mw50Tg | Complex | Fig. 5 from Voltes et al., 2019 | |||
yap1fu48/+; wwtr1fu55/fu55; mw50Tg | Complex | Fig. 5 from Voltes et al., 2019 | |||
amotl2afu46/fu46; yap1fu48/fu48; zf106Tg + MO3-lef1 | Complex | Fig. 7 from Agarwala et al., 2015 | Fig. 7 from Agarwala et al., 2015 |
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Supplemental Information
- Genotyping protocol
- None
- Peralta, M., Ortiz Lopez, L., Jerabkova, K., Lucchesi, T., Vitre, B., Han, D., Guillemot, L., Dingare, C., Sumara, I., Mercader, N., Lecaudey, V., Delaval, B., Meilhac, S.M., Vermot, J. (2020) Intraflagellar Transport Complex B Proteins Regulate the Hippo Effector Yap1 during Cardiogenesis. Cell Reports. 32:107932
- Bornhorst, D., Xia, P., Nakajima, H., Dingare, C., Herzog, W., Lecaudey, V., Mochizuki, N., Heisenberg, C.P., Yelon, D., Abdelilah-Seyfried, S. (2019) Biomechanical signaling within the developing zebrafish heart attunes endocardial growth to myocardial chamber dimensions. Nature communications. 10:4113
- Duchemin, A.L., Vignes, H., Vermot, J. (2019) Mechanically activated Piezo channels modulate outflow tract valve development through the Yap1 and Klf2-Notch signaling axis. eLIFE. 8:
- Voltes, A., Hevia, C.F., Engel, C., Dingare, C., Calzolari, S., Terriente, J., Norden, C., Lecaudey, V., Pujades, C. (2019) Yap/Taz-TEAD activity links mechanical cues to progenitor cell behavior during zebrafish hindbrain segmentation. Development (Cambridge, England). 146(14):
- Agarwala, S., Duquesne, S., Liu, K., Boehm, A., Grimm, L., Link, S., König, S., Eimer, S., Ronneberger, O., Lecaudey, V. (2015) Amotl2a interacts with the Hippo effector Yap1 and the Wnt/β-catenin effector Lef1 to control tissue size in zebrafish. eLIFE. 4:e08201
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