Genomic Feature
hu6024
- ID
- ZDB-ALT-140114-2
- Name
- hu6024
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- Lab of Origin
- Cuppen Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 7: 16593134 (GRCz11) (1) Details
- Nucleotide change
- G/A
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- None
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Ala>Stop at position 2196 (1)
- Flanking Sequence
-
GCCACCAAAACGGTCGCAATTTCAAATTCAAGCACGTTCAAGCACTTTGTGCAAAATCCAAGCACTTTTCTAATTTTAAAAACACTATTTTAGAAATCAAGCATTTTCCAGGATTTCCAGCACCCGTATGAACCCTGCAAGCTTCTGCAATATCGCACAGCCCTACTGATGATTTGATGAATCATTACATAAATTAGCATAGAAACACAATCCAGTTCATGCAAGTATGTATGAGATGCGTAGACACTACTAGAGCCTAAAACTAAAAACAAACAAGTCGTTACCTGCTTTAGAATCCGCTCCTGGAAGATCCGCCAGCCCAGAGTCTCCGTCAACTTCAAAACTGGACATTTCTTCATTCTCCTTCTCCTCTCCATCCAAATCGAACTCTCTCTCTTCTCGCTCTTGACTCCTTTGTCGGATCTGCTGCATAAGCTGTTCATAGCGGTTCTCTTTTCCGGCCCGTTTCAGCACAGCAAGCGTCTGTGCAAGTTTTACTC
G/A ACCATGCCAAGTGTAGCGATTCTTTGCCAGCCGGCTGACCATGTTAAGGCTTTCAAGGACATTCATGATGTCGTAGATGCGACGTCTTTCCACGTCTGAGAGGAAAATGAGCAAGGATACAATTAGGATTGATGGAAAAAAAAATGTATTTCATGGGCCACATTTTATTTTTAGATACAACTTTCGCTATTAACAAACCCTTAACTATGAGTTTAAGCTTAATAAACTTATAATTTACTTATTATTAATAGTTATTAGGTACAATTTGTGTTTAGGTATAAGGTAGGATTAGGAATGTAGAATAAGATCATGCATAATATGTATTTAGGTACTAATAAGCAGCCAATGTCTTATTTATAAGCAGGTAATAATCCACTAGTTCACCGTTTCCCAACTCTGTTCCCGAAGGCACACCAACAGTACATATTTTGGATGTCTCCCTTATCTGACCCATTAACATCAGGATTTGGAGTGGAGTTGATTCGGGTGTGTTTGATTAG - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| e2f7hu6023/hu6023; e2f8hu6024/hu6024; js12Tg | Complex | Fig. 6 from de Bruin et al., 2016 | Fig. 6 from de Bruin et al., 2016 | ||
| e2f7hu6023/hu6023; e2f8hu6024/hu6024; s843Tg | Complex | Fig. 1 from Weijts et al., 2012 | Fig. 1 from Weijts et al., 2012 | ||
| e2f7hu6023/hu6023; e2f8hu6024/+; js12Tg | Complex | Fig. 6 from de Bruin et al., 2016 | Fig. 6 from de Bruin et al., 2016 | ||
| e2f7hu6023/hu6023; e2f8hu6024/+; s843Tg | Complex | Fig. 1 from Weijts et al., 2012 |
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Supplemental Information
- Genotyping protocol
- None
- de Bruin, A., Cornelissen, P.W., Kirchmaier, B.C., Mokry, M., Iich, E., Nirmala, E., Liang, K.H., Végh, A.M., Scholman, K.T., Groot Koerkamp, M.J., Holstege, F.C., Cuppen, E., Schulte-Merker, S., Bakker, W.J. (2016) Genome-wide analysis reveals NRP1 as a direct HIF1α-E2F7 target in the regulation of motorneuron guidance in vivo. Nucleic acids research. 44(8):3549-66
- Weijts, B.G., Bakker, W.J., Cornelissen, P.W., Liang, K.H., Schaftenaar, F.H., Westendorp, B., de Wolf, C.A., Paciejewska, M., Scheele, C.L., Kent, L., Leone, G., Schulte-Merker, S., and de Bruin, A. (2012) E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1. The EMBO journal. 31(19):3871-3884
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