Genomic Feature
sa12953
- ID
- ZDB-ALT-130411-2624
- Name
- sa12953
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation
- Protocol
- adult males treated with ENU
- Lab of Origin
- Stemple Lab
- Current Source
-
European Zebrafish Resource Center (EZRC)
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Zebrafish International Resource Center (ZIRC) ( order this ) - Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 6: 31219099 (GRCz11) (1) Details
- Nucleotide change
- A/T
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>A (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
GAGAGATTTTGTGCGATTAAAAAGATACAAACTGAAGCTGTTTCATACCTATACATTATAATTGTATCTTTGAATCTATAAGTCAGCAAGAGCACGAATACAGATTTAAATATTTGCCATGATACTGATACTGTAATTAGCTAAACTGTAGTTATTTTGGAATTTGATCATGCAGATATTTAATTCAGTCGTTTTGACAATTAATGGTTCAGCCATTGTGGAAAACGTTAAACAAAATATTAAGTAATAAAAAAGTTGAAAGAATTACAGACAGAACAGAGTCTAATAGTGTAGCATAGAGTAGAATAGTATAAAGAAGCAACACTGCACTGGCTGCCATTTATCCAATCATTAGTCAGTGGACAGCTGACTGAAAACAGAAGACTCACACTAATTGATGAGGGCTGACGCTGACCAGAGTGGAAGCTGCTGCTGCTCTACGGGTCTTTGCATTACAAATCAAATTTTCCCGTTCACCTTCAAGCCAGCACAGGATGTCC
A/T AACAGCTTCCTGAAAAGAGATTGCATTCTCTTGTTAGTTACTTTCATGAATCATCCCAGCCCGTTGCAATTAGAAGCCTCAATAATTCCTGTTAGAATTCAGGACACAGCCTCATTACATGATGTGAAAATAACATGAGGATACAAGCGCGATACTTTGAATCGGAATGAAACATCAAATATTAAGTCTAATTGAGATTCTGGCCAGATCTTTTTTTTTTTTTTTTTGATGTTGTTGTTGAAGTTTTAAGCTAAGACCCTTGCAGGAATCCAAGAACAAAATATCTGGGGAATGTTTTATGAATGCTTTATAGTGTTACAAAAAAAAAAATCTACCTCTAAGTATTTGTATCAATTCTTTTTCTGTTTTTGAAGAGCCACTTCACACGTTGGATTGCAAACAAACTTGTTTTGCATTTAAATGCTATATATTTAGTTGAGGGCTTTAATCACTGCCCCGAGGCCCACCACCACAGTGAAGAGAAAGTAATGAGAATTGAT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| leprsa12953/sa12953 | Homozygous | ♀+/- ♂+/- | 5 figures  from Tsakoumis et al., 2022 | 15 figures from 4 publications |
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Supplemental Information
- Genotyping protocol
- None
- Ahi, E.P., Brunel, M., Tsakoumis, E., Chen, J., Schmitz, M. (2022) Appetite regulating genes in zebrafish gut; a gene expression study. PLoS One. 17:e0255201
- Tsakoumis, E., Ahi, E.P., Schmitz, M. (2022) Impaired leptin signaling causes subfertility in female zebrafish. Molecular and Cellular Endocrinology. 546:111595
- Ahi, E.P., Tsakoumis, E., Brunel, M., Schmitz, M. (2021) Transcriptional study reveals a potential leptin-dependent gene regulatory network in zebrafish brain. Fish physiology and biochemistry. 47(4):1283-1298
- Ahi, E.P., Brunel, M., Tsakoumis, E., Schmitz, M. (2019) Transcriptional study of appetite regulating genes in the brain of zebrafish (Danio rerio) with impaired leptin signalling. Scientific Reports. 9:20166
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