Genomic Feature
hkz3
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 23: 31822034 (GRCz11) (1) Details
- Nucleotide change
- T/A
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>A in Intron 8 (1)
- Transcript Consequence
- Splicing Variant (1)
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
TGCAACACATTTATTAAACAGATATTTTTTATGTGAATCCCTCAAAAAATACACGCTTTCATGTCATTTTTCCCATTTATAATCACAATTTGAGCTTAATAAACAAACACTGAATTTACTTTGCTCTCATCTCACATAGAGACACTACAGCGACGAGGACCCCGAAAAAGAAAAGAGGGTGAAAGAAATCGAGATGCTGTTGATGTCAACAGAAAACGAGCTGAAGGGACAACAGGCACTACCAGTAAGTGTGTCTCTCTGTGCGTGTGTGTGTGTGTTTAATTGGAGGAAGCATCTGGGGGTCTATTTCACATGCTTCAACTGCTTGGCTAAATGATGCAATTGCACCTTATCACACCACAAGCTCTGTTTAACTCCTTGTGCAACTGAGAACCCCCTCCCAACCCTTCACATCATTCAACTCGACAAGTTCCCTTTCTCTCTGACCGCTTTTCCTGCATGCATTCCTCTCTTTCTTTCGCTTAATTTTGCTCTTTTTT
T/A GTTCCCCCACCCAGATCTCCATGAACGGCTACGGTGGCTGGAACAGAGGCTCTTTGGCGGACAGTTCGGTTGGCATTGTTGTTTCAGTCCCGGCTCCATCCCTAGAGCAAGGATGCCTTCCTGAAGAAAGCGCACATGGCAACACAAACAGCCCAAATAACGACTCCAGCTCCACTTTACCAGAGTTTATCGATGCTATTGATTCGGTAAGTTCATCTAAAATGAACAGTGACCATGTATTCATCAGCTAGCATCTAGCGTTAAAGGGATAGTTCACTCAAAAACTAAAAATTCTGTCATCATTTACTCACCTTTCACTTGAGTTTCTTTCTCCTATTAAACAAAAGAGAAGGTATTTTGAAGAAAGTTGAAAACTTGTAACCTTTGACTTCCATAGTATTTGATTTCCAACATACTACTCAATGGTTACAGGTTTTCAGCTCATCTTCTTTAGTGTTCAGCAGAAGAAAGAAACTCCTAAGTGTTTTGAAACCACACGA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| mybhkz3/hkz3 | Homozygous | ♀+/- ♂+/- | 3 figures  from 2 publications | 3 figures from 2 publications | |
| mybhkz3/hkz3 | Homozygous | Unknown | 3 figures from 2 publications | 3 figures from 2 publications | |
| mybhkz3/+ | Heterozygous | Unknown | Fig. 5 from Jin et al., 2016 | ||
| mybhkz3/hkz3; i114Tg | Complex | 2 figures from Jin et al., 2016 | 2 figures from Jin et al., 2016 | ||
| mybhkz3/hkz3; la2Tg | Complex | 5 figures from Zhang et al., 2011 | 3 figures from Zhang et al., 2011 | ||
| mybhkz3/hkz3; cebp1sm6a/sm6a | Complex | Fig. 4 from Jin et al., 2016 | Fig. 4 from Jin et al., 2016 | ||
| mybhkz3/hkz3; cebp1sm6a/sm6a; i114Tg | Complex | Fig. 4 from Jin et al., 2016 | Fig. 4 from Jin et al., 2016 | ||
| mybhkz3/+; cebp1sm6a/sm6a | Complex | Fig. 5 from Jin et al., 2016 | |||
| mybhkz3/+; cebp1sm6a/+ | Complex | Fig. 5 from Jin et al., 2016 | |||
| mybhkz3/hkz3; la2Tg + MO3-cxcl12a | Complex | Fig. 5 from Zhang et al., 2011 |
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Supplemental Information
- Genotyping protocol
- None
- Xu, S., Hong, J., Dongye, M., Lin, J., Xue, R., Huang, Z., Xu, J., Zhang, Y., Leung, A.Y., Shen, J., Zhang, W., Liu, W. (2025) The synergistic effect of c-Myb hyperactivation and Pu.1 deficiency induces Pelger-Huët anomaly and promotes sAML. Proceedings of the National Academy of Sciences of the United States of America. 122:e2416121122e2416121122
- Huang, Z., Chen, K., Chi, Y., Jin, H., Li, L., Zhang, W., Xu, J., Zhang, Y. (2021) Runx1 regulates zebrafish neutrophil maturation via synergistic interaction with c-Myb. The Journal of biological chemistry. 296:100272
- Zhang, A., Wu, M., Tan, J., Yu, N., Xu, M., Yu, X., Liu, W., Zhang, Y. (2019) Establishment of a zebrafish hematological disease model induced by 1,4-benzoquinone. Disease models & mechanisms. 12(3):
- He, S., Chen, J., Jiang, Y., Wu, Y., Zhu, L., Jin, W., Zhao, C., Yu, T., Wang, T., Wu, S., Lin, X., Qu, J.Y., Wen, Z., Zhang, W., Xu, J. (2018) Adult zebrafish Langerhans cells arise from hematopoietic stem/progenitor cells. eLIFE. 7
- Liu, W., Wu, M., Huang, Z., Lian, J., Chen, J., Wang, T., Leung, A.Y., Liao, Y., Zhang, Z., Liu, Q., Yen, K., Lin, S., Zon, L.I., Wen, Z., Zhang, Y., Zhang, W. (2017) c-myb hyperactivity leads to myeloid and lymphoid malignancies in zebrafish. Leukemia. 31(1):222-233
- Jin, H., Huang, Z., Chi, Y., Wu, M., Zhou, R., Zhao, L., Xu, J., Zhen, F., Lan, Y., Li, L., Zhang, W., Wen, Z., Zhang, Y. (2016) cMyb acts in parallel and cooperatively with Cebp1 to regulate neutrophil maturation in zebrafish. Blood. 128(3):415-26
- Meng, P., Liu, Y., Chen, X., Zhang, W., Zhang, Y. (2016) Zebrafish Cdh5 negatively regulates mobilization of aorta-gonad-mesonephros-derived hematopoietic stem cells. Journal of genetics and genomics = Yi chuan xue bao. 43(10):613-616
- Xu, J., Zhu, L., He, S., Wu, Y., Jin, W., Yu, T., Qu, J.Y., Wen, Z. (2015) Temporal-Spatial Resolution Fate Mapping Reveals Distinct Origins for Embryonic and Adult Microglia in Zebrafish. Developmental Cell. 34:632-641
- Wang, L., Fu, C., Fan, H., Du, T., Dong, M., Chen, Y., Jin, Y., Zhou, Y., Deng, M., Gu, A., Jing, Q., Liu, T., and Zhou, Y. (2013) miR-34b regulates multiciliogenesis during organ formation in zebrafish. Development (Cambridge, England). 140(13):2755-2764
- Zhang, Y., Jin, H., Li, L., Qin, F.X., and Wen, Z. (2011) cMyb regulates hematopoietic stem/progenitor cell mobilization during zebrafish hematopoiesis. Blood. 118(15):4093-101
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