ZFIN Lab: Wen Lab

ZFIN ID: ZDB-LAB-011010-6

Wen Lab

PI/Director:	Wen, Zilong
Contact Person:	Wen, Zilong
Email:	zilong@ust.hk
URL:	http://www.ust.hk/bich/facultyprofiles/zlwen.html
Address:	Department of Biochemistry Hong Kong University of Science and Technology Clear Water Bay Hong Kong, China
Country:	China
Phone:	852-23587282
Fax:	852-23581552
Line Designation:	hkz

GENOMIC FEATURES ORIGINATING FROM THIS LAB

Show first 50 of 64 genomic features

STATEMENT OF RESEARCH INTERESTS

LAB MEMBERS

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Zhao, S., Zhang, A., Zhu, H., Wen, Z. (2022) The ETS transcription factor Spi2 regulates hematopoietic cell development in zebrafish. Development (Cambridge, England). 149(19)

Lou, L., Yu, T., Dai, Y., Zhao, S., Feng, S., Xu, J., Wen, Z. (2022) Mafba and Mafbb regulate microglial colonization of zebrafish brain via controlling chemotaxis receptor expression. Proceedings of the National Academy of Sciences of the United States of America. 119:e2203273119

Dai, Y., Wu, S., Cao, C., Xue, R., Luo, X., Wen, Z., Xu, J. (2022) Csf1rb regulates definitive hematopoiesis in zebrafish. Development (Cambridge, England). 149(16)

Zhao, Y., Wu, M., Li, J., Meng, P., Chen, J., Huang, Z., Xu, J., Wen, Z., Zhang, W., Zhang, Y. (2021) The spliceosome factor sart3 regulates hematopoietic stem/progenitor cell development in zebrafish through the p53 pathway. Cell Death & Disease. 12:906

Li, H., Nam, Y., Huo, R., Fu, W., Biaobin, J., Zhou, Q., Song, D., Yang, Y., Jiao, Y., Weng, J., Yan, Z., Di, L., Li, J., Wang, J., Xu, H., Wang, S., Zhao, J., Wen, Z., Jiguang, W., Cao, Y. (2021) De Novo Germline and Somatic Variants Convergently Promote Endothelial-to-Mesenchymal Transition in Simplex Brain Arteriovenous Malformation. Circulation research. 129(9):825-839

Chen, J., Li, G., Lian, J., Ma, N., Huang, Z., Li, J., Wen, Z., Zhang, W., Zhang, Y. (2021) Slc20a1b is essential for hematopoietic stem/progenitor cell expansion in zebrafish. Science China. Life sciences. 64(12):2186-2201

Lin, X., Zhou, Q., Lin, G., Zhao, C., Wen, Z. (2020) Endoderm-Derived Myeloid-like Metaphocytes in Zebrafish Gill Mediate Soluble Antigen-Induced Immunity. Cell Reports. 33:108227

Yu, T., Kuang, H., Chen, J., Lin, X., Wu, Y., Chen, K., Zhang, M., Zhang, W., Wen, Z. (2020) Tripartite-motif family protein 35-28 regulates microglia development by preventing necrotic death of microglial precursors in zebrafish. The Journal of biological chemistry. 295(26):8846-8856

He, S., Tian, Y., Feng, S., Wu, Y., Shen, X., Chen, K., He, Y., Sun, Q., Li, X., Xu, J., Wen, Z., Qu, J.Y. (2020) In vivo single-cell lineage tracing in zebrafish using high-resolution infrared laser-mediated gene induction microscopy. eLIFE. 9:

Wang, T., Yan, B., Lou, L., Lin, X., Yu, T., Wu, S., Lu, Q., Liu, W., Huang, Z., Zhang, M., Zhang, W., Wen, Z. (2019) Nlrc3-like is required for microglia maintenance in zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 46(6):291-299

Lin, X., Zhou, Q., Zhao, C., Lin, G., Xu, J., Wen, Z. (2019) An Ectoderm-Derived Myeloid-like Cell Population Functions as Antigen Transporters for Langerhans Cells in Zebrafish Epidermis. Developmental Cell. 49(4):605-617.e5

Jin, W., Dai, Y., Li, F., Zhu, L., Huang, Z., Liu, W., Li, J., Zhang, M., Du, J., Zhang, W., Wen, Z. (2019) Dysregulation of Microglial Function Contributes to Neuronal Impairment in Mcoln1a-Deficient Zebrafish. iScience. 13:391-401

Wu, S., Xue, R., Hassan, S., Nguyen, T.M.L., Wang, T., Pan, H., Xu, J., Liu, Q., Zhang, W., Wen, Z. (2018) Il34-Csf1r Pathway Regulates the Migration and Colonization of Microglial Precursors. Developmental Cell. 46:552-563.e4

He, S., Chen, J., Jiang, Y., Wu, Y., Zhu, L., Jin, W., Zhao, C., Yu, T., Wang, T., Wu, S., Lin, X., Qu, J.Y., Wen, Z., Zhang, W., Xu, J. (2018) Adult zebrafish Langerhans cells arise from hematopoietic stem/progenitor cells. eLIFE. 7

Tian, Y., Xu, J., Feng, S., He, S., Zhao, S., Zhu, L., Jin, W., Dai, Y., Luo, L., Qu, J.Y., Wen, Z. (2017) The first wave of T lymphopoiesis in zebrafish arises from aorta endothelium independent of hematopoietic stem cells. The Journal of experimental medicine. 214(11):3347-3360

Yu, T., Guo, W., Tian, Y., Xu, J., Chen, J., Li, L., Wen, Z. (2017) Distinct regulatory networks control the development of macrophages of different origins in zebrafish. Blood. 129(4):509-519

Dai, Y., Zhu, L., Huang, Z., Zhou, M., Jin, W., Liu, W., Xu, M., Yu, T., Zhang, Y., Wen, Z., Liao, W., Zhang, W. (2016) Cebpα is essential for the embryonic myeloid progenitor and neutrophil maintenance in zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 43(10):593-600

Xu, J., Wang, T., Wu, Y., Jin, W., Wen, Z. (2016) Microglia Colonization of Developing Zebrafish Midbrain Is Promoted by Apoptotic Neuron and Lysophosphatidylcholine. Developmental Cell. 38(2):214-22

Jin, H., Huang, Z., Chi, Y., Wu, M., Zhou, R., Zhao, L., Xu, J., Zhen, F., Lan, Y., Li, L., Zhang, W., Wen, Z., Zhang, Y. (2016) cMyb acts in parallel and cooperatively with Cebp1 to regulate neutrophil maturation in zebrafish. Blood. 128(3):415-26

Wei, Y., Xu, J., Zhang, W., Wen, Z., Liu, F. (2016) RNA polymerase III component Rpc9 regulates hematopoietic stem and progenitor cell maintenance in zebrafish. Development (Cambridge, England). 143(12):2103-10

Xu, J., Zhu, L., He, S., Wu, Y., Jin, W., Yu, T., Qu, J.Y., Wen, Z. (2015) Temporal-Spatial Resolution Fate Mapping Reveals Distinct Origins for Embryonic and Adult Microglia in Zebrafish. Developmental Cell. 34:632-641

Shi, X., He, B.L., Ma, A.C., Guo, Y., Chi, Y., Man, C.H., Zhang, W., Zhang, Y., Wen, Z., Cheng, T., Leung, A.Y. (2015) Functions of idh1 and its mutation in the regulation of developmental hematopoiesis in zebrafish. Blood. 125(19):2974-84

Yuan, H., Zhang, T., Liu, X., Deng, M., Zhang, W., Wen, Z., Chen, S., Chen, Z., de The, H., Zhou, J., Zhu, J. (2015) Sumoylation of CCAAT/enhancer-binding protein α is implicated in hematopoietic stem/progenitor cell development through regulating runx1 in zebrafish. Scientific Reports. 5:9011

Zeng, Y., Yan, B., Xu, J., Sun, Q., He, S., Jiang, J., Wen, Z., Qu, J.Y. (2014) In Vivo nonlinear optical imaging of immune responses: tissue injury and infection. Biophysical journal. 107:2436-43

Yan, B., Han, P., Pan, L., Lu, W., Xiong, J., Zhang, M., Zhang, W., Li, L., Wen, Z. (2014) Il-1beta and Reactive Oxygen Species Differentially Regulate Neutrophil Directional Migration and Basal Random Motility in a Zebrafish Injury-Induced Inflammation Model. Journal of immunology (Baltimore, Md. : 1950). 192(12):5998-6008

Zeng, Y., Yan, B., Sun, Q., He, S., Jiang, J., Wen, Z., Qu, J.Y. (2014) In vivo micro-vascular imaging and flow cytometry in zebrafish using two-photon excited endogenous fluorescence. Biomedical Optics Express. 5:653-63

Zhen, F., Lan, Y., Yan, B., Zhang, W., and Wen, Z. (2013) Hemogenic endothelium specification and hematopoietic stem cell maintenance employ distinct Scl isoforms. Development (Cambridge, England). 140(19):3977-3985

Li, Y., Du, X.F., Liu, C.S., Wen, Z.L., and Du, J.L. (2012) Reciprocal Regulation between Resting Microglial Dynamics and Neuronal Activity In Vivo. Developmental Cell. 23(6):1189-1202

Li, X., Lan, Y., Xu, J., Zhang, W., and Wen, Z. (2012) SUMO1-activating enzyme subunit 1 is essential for the survival of hematopoietic stem/progenitor cells in zebrafish. Development (Cambridge, England). 139(23):4321-4329

Xu, J., Du, L., and Wen, Z. (2012) Myelopoiesis during zebrafish early development. Journal of genetics and genomics = Yi chuan xue bao. 39(9):435-442

Li, L., Yan, B., Shi, Y.Q., Zhang, W.Q., and Wen, Z.L. (2012) Live imaging reveals differing roles of macrophages and neutrophils during Zebrafish tail fin regeneration. The Journal of biological chemistry. 287(30):25353-25360

Zeng, Y., Xu, J., Li, D., Li, L., Wen, Z., and Qu, J.Y. (2012) Label-free in vivo flow cytometry in zebrafish using two-photon autofluorescence imaging. Optics letters. 37(13):2490-2492

Jin, H., Li, L., Xu, J., Zhen, F., Zhu, L., Liu, P.P., Zhang, M., Zhang, W., and Wen, Z. (2012) Runx1 regulates embryonic myeloid fate choice in zebrafish through a negative feedback loop inhibiting Pu.1 expression. Blood. 119(22):5239-5249

Zhang, Y., Jin, H., Li, L., Qin, F.X., and Wen, Z. (2011) cMyb regulates hematopoietic stem/progenitor cell mobilization during zebrafish hematopoiesis. Blood. 118(15):4093-101

Jin, H., and Wen, Z. (2011) Erythrocytes in the trunk of zebrafish embryos. Development (Cambridge, England). 138(18):3862-3863

Yan, G., Liu, W., Dai, Z.X., Wang, K., Liu, J., Zhao, L.F., Huang, Z.B., Chen, X.H., Ma, N., Meng, P., Xu, M.C., Wen, Z.L., and Zhang, W.Q. (2011) Study of a new zebrafish mutant defective in primitive myelopoiesis. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 31(5):755-760

Du, L., Xu, J., Li, X., Ma, N., Liu, Y., Peng, J., Osato, M., Zhang, W., and Wen, Z. (2011) Rumba and Haus3 are essential factors for the maintenance of hematopoietic stem/progenitor cells during zebrafish hematopoiesis. Development (Cambridge, England). 138(4):619-629

Li, L., Jin, H., Xu, J., Shi, Y., and Wen, Z. (2011) Irf8 regulates macrophage versus neutrophil fate during zebrafish primitive myelopoiesis. Blood. 117(4):1359-1369

Ng, C.E., Yokomizo, T., Yamashita, N., Cirovic, B., Jin, H., Wen, Z., Ito, Y., and Osato, M. (2010) A Runx1 Intronic Enhancer Marks Hemogenic Endothelial Cells and Hematopoietic Stem Cells. Stem cells (Dayton, Ohio). 28(10):1869-1881

Sood, R., English, M.A., Belele, C.L., Jin, H., Bishop, K., Haskins, R., McKinney, M.C., Chahal, J., Weinstein, B.M., Wen, Z., and Liu, P.P. (2010) Development of multilineage adult hematopoiesis in the zebrafish with a runx1 truncation mutation. Blood. 115(14):2806-2809

Jin, H., Sood, R., Xu, J., Zhen, F., English, M.A., Liu, P.P., and Wen, Z. (2009) Definitive hematopoietic stem/progenitor cells manifest distinct differentiation output in the zebrafish VDA and PBI. Development (Cambridge, England). 136(4):647-654

Huang, H., Ruan, H., Aw, M.Y., Hussain, A., Guo, L., Gao, C., Qian, F., Leung, T., Song, H., Kimelman, D., Wen, Z., and Peng, J. (2008) Mypt1-mediated spatial positioning of Bmp2-producing cells is essential for liver organogenesis. Development (Cambridge, England). 135(19):3209-3218

Liu, Y., Du, L., Osato, M., Teo, E.H., Qian, F., Jin, H., Zhen, F., Xu, J., Guo, L., Huang, H., Chen, J., Geisler, R., Jiang, Y.J., Peng, J., and Wen, Z. (2007) The zebrafish udu gene encodes a novel nuclear factor and is essential for primitive erythroid cell development. Blood. 110(1):99-106

Jin, H., Xu, J., and Wen, Z. (2007) Migratory path of definitive hematopoietic stem/progenitor cells during zebrafish development. Blood. 109(12):5208-5214

Qian, F., Zhen, F., Xu, J., Huang, M., Li, W., and Wen, Z. (2007) Distinct Functions for Different scl Isoforms in Zebrafish Primitive and Definitive Hematopoiesis. PLoS Biology. 5(5):e132

Huang, H., Lu, F.I., Jia, S., Meng, S., Cao, Y., Wang, Y., Ma, W., Yin, K., Wen, Z., Peng, J., Thisse, C., Thisse, B., and Meng, A. (2007) Amotl2 is essential for cell movements in zebrafish embryo and regulates c-Src translocation. Development (Cambridge, England). 134(5):979-988

Jin, H., Xu, J., Qian, F., Du, L., Tan, C.Y., Lin, Z., Peng, J., and Wen, Z. (2006) The 5' zebrafish scl promoter targets transcription to the brain, spinal cord, and hematopoietic and endothelial progenitors. Developmental Dynamics : an official publication of the American Association of Anatomists. 235(1):60-67

Chen, J., Ruan, H., Ng, S.M., Gao, C., Soo, H.M., Wu, W., Zhang, Z., Wen, Z., Lane, D.P., and Peng, J. (2005) Loss of function of def selectively up-regulates {Delta}113p53 expression to arrest expansion growth of digestive organs in zebrafish. Genes & Development. 19(23):2900-2911

Qian, F., Zhen, F., Ong, C., Jin, S.W., Meng Soo, H., Stainier, D.Y., Lin, S., Peng, J., and Wen, Z. (2005) Microarray analysis of zebrafish cloche mutant using amplified cDNA and identification of potential downstream target genes. Developmental Dynamics : an official publication of the American Association of Anatomists. 233(3):1163-1172

Wen, C., Zhang, Z., Ma, W., Xu, M., Wen, Z., and Peng, J. (2005) Genome-wide identification of female-enriched genes in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 232(1):171-179

Lo, J., Lee, S., Xu, M., Liu, F., Ruan, H., Eun, A., He, Y., Ma, W., Wang, W., Wen, Z., and Peng, J. (2003) 15,000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Genome research. 13(3):455-466

Liu, F. and Wen, Z. (2002) Cloning and expression pattern of the lysozyme C gene in zebrafish. Mechanisms of Development. 113(1):69-72