Genomic Feature
z26
- ID
- ZDB-ALT-120308-1
- Name
- z26
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- Lab of Origin
- Grunwald Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 10: 7311978 (GRCz11) (1) Details
- Nucleotide change
- A/G
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>C (1)
- Transcript Consequence
- Missense (1)
- Protein Consequence
- Amino Acid Substitution: Cys>Arg (1)
- Flanking Sequence
-
GTTATTAGAAATTAGTTATTAAAACTTTTATCTTTAGAAATGTGTTGAAAAAATTTCTCCATTCAACATATATTGGAAAAAAATTAATAATTTATTTTAATAATTCAGGGGAGCTAATAATTCTGACTTCAACTGTAGGTCTGCAATTCAGTGCAGTACAGAATAGGTCTTTCAGCTTTATTTAGAAGCGCTCATTTCTTGTGTCAAAGCATGGAAAAGATGCTCTCGGGAGCCTCTGTAAAACCTTTAATTTTCCTGGCAAATACGTCCTAAGTTCTTCATATAAAATAAGTGTTTTACAGACAATGTAGGAACTCAGGAAAATAGCATGCTCCCTTAAGGTAGATGAAATGCTGTTCACTCAGTGGCAATTAAATAAAACAGTGAATAAATGAAAATATCTCCTTTAAACATCAACATGTAGAACGACAGTGTGACGGCAGGCTACATTACTGTGTGTTCAACATGAAATATAGATGCGGATTTGCGGCAATACCTGC
A/G GAGGCGCCTGATGTTGCCTGGTGTGACCTCCAGCGTGAAGCACTTGCCATGGTTTACACAGTATTCCTTCTCGCTCTCATTGCAGGGCGTCACGTGACTGGATGTCTTGGCCGAGGGAGTGGTGCTGGTGGCTGCTGCACAGAGGAACACAACACACAAGTGCAATGAGGAGGAGAGGTTTTACTGCAGAGCATCTGATTAAGGAACACTAATCTGAGATGGAGAAGTGAAATGTCTGAACTGCCGTTTATGACATGCAAACTATGCGCATCTGATCCAAATGACCTTCACAAAATAAATGCAAAGCATTAGAAAAGCTGACTCTTTTAAGCTACTTAAGTAACCGCAGGCTCAATATTTTTCACTAAAATTCAAATAAACATGTTTCTATTCAGATACGTCCAACAAAGCAGCAGTGAACAATGTCAAGATTTAGTTTTAAGCAAGTAACATTATCAAAATTAAAACACCTTAAGCAACCTTGTAAATTTGTACATTGT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| nrg1z26/z26 | Homozygous | ♀+/- ♂+/- | 8 figures  from 4 publications | 6 figures from 3 publications | |
| nrg1z26/+ | Heterozygous | ♀+/- ♂+/- | Fig. 3 from Perlin et al., 2011 | 2 figures from Perlin et al., 2011 | |
| nrg1z26/+; zf15Tg | Complex | Fig. 2 from Perlin et al., 2011 | |||
| nrg1z26/z26; ml2Tg | Complex | Fig. 3 from Rosenberg et al., 2014 | |||
| nrg1z26/z26; zf15Tg | Complex | Fig. 2 from Perlin et al., 2011 | Fig. 2 from Perlin et al., 2011 | ||
| nrg1z26/z26; paf1z24/z24 | Complex | Fig. 7 from Jurynec et al., 2019 |
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Supplemental Information
- Genotyping protocol
- None
- Fontenas, L., Kucenas, S. (2021) Spinal cord precursors utilize neural crest cell mechanisms to generate hybrid peripheral myelinating glia. eLIFE. 10:
- Jurynec, M.J., Bai, X., Bisgrove, B.W., Jackson, H., Nechiporuk, A., Palu, R.A.S., Grunwald, H.A., Su, Y.C., Hoshijima, K., Yost, H.J., Zon, L.I., Grunwald, D.J. (2019) The Paf1 Complex and P-TEFb have reciprocal and antagonist roles in maintaining multipotent neural crest progenitors. Development (Cambridge, England). 146(24):
- Brown, D., Samsa, L.A., Ito, C., Ma, H., Batres, K., Arnaout, R., Qian, L., Liu, J. (2017) Neuregulin-1 is essential for nerve plexus formation during cardiac maturation. Journal of Cellular and Molecular Medicine. 22(3):2007-2017
- Samsa, L.A., Ito, C.E., Brown, D.R., Qian, L., Liu, J. (2016) IgG-Containing Isoforms of Neuregulin-1 Are Dispensable for Cardiac Trabeculation in Zebrafish. PLoS One. 11:e0166734
- Lush, M.E., Piotrowski, T. (2014) ErbB expressing Schwann cells control lateral line progenitor cells via non-cell-autonomous regulation of Wnt/beta-catenin. eLIFE. 3:e01832
- Rosenberg, A.F., Isaacman-Beck, J., Franzini-Armstrong, C., Granato, M. (2014) Schwann cells and deleted in colorectal carcinoma direct regenerating motor axons towards their original path. The Journal of neuroscience : the official journal of the Society for Neuroscience. 34:14668-81
- Perlin, J.R., Lush, M.E., Stephens, W.Z., Piotrowski, T., and Talbot, W.S. (2011) Neuronal Neuregulin 1 type III directs Schwann cell migration. Development (Cambridge, England). 138(21):4639-4648
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