Genomic Feature
sa115
- ID
- ZDB-ALT-100506-15
- Name
- sa115
- Synonyms
-
- sa0115 (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Stemple Lab
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 5: 51618607 (GRCz11) (1) Details
- Nucleotide change
- G/-
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 1 bp deleted (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- at position 96 (1)
- Flanking Sequence
-
TTAAAGCACTGTGCAATCTACTGTGCAAGCTACTATTTTAATGAATTCTTTTAGAGCACGTCTTTTTTTCTAAAAAGCTTTTTTTGTAATATTATATTTTAGTACAGGCAACACTGCAATAGTTTTAGATGCGCGATCGGAAACATATTTGACATTGTTTTTAGAGAAAATCGCCAAGTAATTCATGCAATAAATTTCGTATGTCTTTAGAACTAAATTAATAAATAAGTGTTACGCCAAGCGATTCAGTTTGCTTTTACAAACAGGCAATAACCGTCTGGAAAGTCAGAGCTGAGCAAGTTCATTAAGTCTCACCTGAACCCGTGACTCCGTTAAACCAATCCTTAATGCAAGTTCCTCTCTCATAAAAATATCAGGATAGTGGGTTTTAGCAAAGCTCCTTTCTAGTTCGTTCAGCTGGGCTGGAGTAAAACGGGTCCTGTGGCGTTTCTGTTTCTGTTGGTTTTGCTGGCCGCCCGTCTGATTGGAGTTTTGCTGTT
G/- CTGCTTTTCTTGGTCTTTGGCGTTGACCTGCTGCATTCCATTAGGATTGGATCCACCATTACTTATTTCTTCTCCGGGGAGCAGAGTGGTCCCCTCCACAGTCTCTGTGGCAGAAGTAAGGTCGCCGGGGTGTCCAGAGTCAGTCCCCCCTAGTCTGCATTTTAAAGCTTCTCGGTGTACGAGAAGCTCGGCTGCAGCATCCTTCATCCCTGTGGACGCAGGTGTCAACAATTTAGCATTCTATCCAAATGGCTGTTTCATATTAATATCAATAATCAACGCATATTTAAAACACGCTACTTATTGATACATTTGTCGCACAAATAATCATAAACATATAGCAAATAATACCAAACATAAACACCACAAACATTAAAATTATTTTAGCAAGGGAAAAAAACAATACTTTTAGTAATTATCACGTAACATTGCATGTATAATGCACATATTAAAATATAATATAAACATAAAATTGGTTCACCAGACTGAAGACTGAATAA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| otpbsa115/sa115 | Homozygous | ♀+/- ♂+/- | 6 figures  from 3 publications | ||
| otpbsa115/sa115 (TL) | Homozygous | ♀+/- ♂+/- | text only from Busch-Nentwich et al., 2012 | ||
| otpbsa115 | Unknown | Unknown | |||
| otpbsa115/sa115; wz01Tg | Complex | Fig. 5 from Wircer et al., 2017 | |||
| otpam866/m866; otpbsa115/sa115 | Complex | 7 figures from 2 publications | |||
| otpam866/m866; otpbsa115/sa115 | Complex | 2 figures from 2 publications | |||
| otpam866/m866; otpbsa115/+ | Complex | 3 figures from 2 publications | |||
| otpam866/+; otpbsa115/sa115 | Complex | 2 figures from 2 publications | |||
| otpam866/+; otpbsa115/+ | Complex | 2 figures from Fernandes et al., 2012 |
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Supplemental Information
- Genotyping protocol
- None
- Schredelseker, T., Veit, F., Dorsky, R.I., Driever, W. (2020) Bsx Is Essential for Differentiation of Multiple Neuromodulatory Cell Populations in the Secondary Prosencephalon. Frontiers in neuroscience. 14:525
- Wircer, E., Blechman, J., Borodovsky, N., Tsoory, M., Nunes, A.R., Oliveira, R.F., Levkowitz, G. (2017) Homeodomain protein Otp affects developmental neuropeptide switching in oxytocin neurons associated with a long-term effect on social behavior. eLIFE. 6
- Fontaine, R., Affaticati, P., Bureau, C., Colin, I., Demarque, M., Dufour, S., Vernier, P., Yamamoto, K., Pasqualini, C. (2015) The Dopaminergic Neurons Controlling Anterior Pituitary Functions: Anatomy and Ontogenesis in Zebrafish. Endocrinology. 156(8):2934-48
- Fernandes, A.M., Beddows, E., Filippi, A., and Driever, W. (2013) Orthopedia Transcription Factor otpa and otpb Paralogous Genes Function during Dopaminergic and Neuroendocrine Cell Specification in Larval Zebrafish. PLoS One. 8(9):e75002
- Fernandes, A.M., Fero, K., Arrenberg, A.B., Bergeron, S.A., Driever, W., and Burgess, H.A. (2012) Deep Brain Photoreceptors Control Light-Seeking Behavior in Zebrafish Larvae. Current biology : CB. 22(21):2042-2047
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