Genomic Feature
hg1
- ID
- ZDB-ALT-091019-1
- Name
- hg1
- Synonyms
-
- w84x (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- P. Paul Liu Lab
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 1: 1395348 (GRCz11) (1) Details
- Nucleotide change
- C/T
- Variant Notes
-
truncation of the mutant protein is in the Runt domain
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- G>A in Exon 4 (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation: Trp>Stop at position 84 (1)
- Flanking Sequence
-
TTCAACTTTAAAAGAACCCAAAAAATAGCACAAACGAATCAACTACAGTCAGTGTTATGTAAAAAATAATTGATCATGTGCCACAGAACTATTCGTTCATTCATTTTCTGTCCCTTTATTCATCAGGGGGTCACCACAGTGGAATGAACCGCCAACTATTCCAACATAAGTTTAGCATTTGCCCTTCCAGCTGCAACCCAGTGCTGGGAAACACCCATACACACTCATTCATTCACACACACTCATACACTACGGCCAGTTTAGTTGATCAGTTCCCCTATAGCGCATGTGTTTGGACTGTGGGGGAAACCGGAGCACCCGGAGAAAACCCACAACAACACGAGGAGAACATGCAAACTCCAGACTGAAATGCCAACTGACCCAGCCGGGACTCTAACTAGCTTCTTGCTGTGACACTGAGCCACCAAGCTGCCCAAAAATAACCCATATAAAACAGGTTCTGGTACCTTGAAGGCGATGGGCAGGGTCTTGTTGCAGCG
C/T CAGTGTGTCGGCAGGACGGAGCAGAGGAAGTTCGGGCTGTCGGTGCGCACCAGTTCCCCCGGGTGGTCGGACAGTACTTCCACCATGCTGCGGTCTGCCATGCGCAGTTTGCCCACCAGAGCGGCGCCGGTGCTCTCCTGAGCCCCCAGAGGCAAACCCTCGCTCATCTTCCCCGAGCTCAGGGTGGTGGAGGGAGGCGTGAAGCGTCGCCCGGGCGCAGGTTCTGAAACACAGGCCAGTGTTAAAGTGAATTCAACAAGGTAAGGCAAGCTTACGAATAAAAGAGACAAGTAAAAAAAAATTAAGAAAATAAAAACAAATATTATTAAAAACAGATTAAAATGTGTTAAAACAGGAATAATAAGTGCTCACGTGGGTTTCCCCTGGCTTCCCGGTTTCTTCCCACTATCCAAAAACATGCAACTTAAGTTAATTGACTAATTTAAATCGCCACCATAGACATGCTCCTAGTGAGTAAATATCCCTTAAGAGCGATCACT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| runx1hg1/hg1 | Homozygous | Unknown | Fig. S2  from Chi et al., 2018 | 2 figures from 2 publications | |
| runx1hg1/hg1 | Homozygous | ♀+/- ♂+/- | 12 figures from 7 publications | 17 figures from 11 publications | |
| runx1hg1/+ | Heterozygous | Unknown | Fig. 2 from Dobrzycki et al., 2018 | ||
| runx1hg1/+ (AB) | Heterozygous | Unknown | |||
| runx1hg1/hg1; a129Tg | Complex | Fig. 8 from Gau et al., 2017 | |||
| runx1hg1/hg1; hkz016tTg | Complex | 2 figures from Chi et al., 2018 | |||
| runx1hg1/hg1; la2Tg | Complex | Fig. 2 from Sood et al., 2010 | Fig. 2 from Sood et al., 2010 | ||
| runx1hg1/hg1; ox1Tg | Complex | 3 figures from Koth et al., 2020 | |||
| runx1hg1/hg1; ox1Tg; s896Tg | Complex | 2 figures from 2 publications | |||
| runx1hg1/hg1; s843Tg | Complex | Fig. 4 from Zhan et al., 2018 | Fig. 4 from Zhan et al., 2018 |
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Supplemental Information
- Genotyping protocol
- None
- Luo, H., Li, Q., Hong, J., Huang, Z., Deng, W., Wei, K., Lu, S., Wang, H., Zhang, W., Liu, W. (2024) Targeting TNF/IL-17/MAPK pathway in hE2A-PBX1 leukemia: effects of OUL35, KJ-Pyr-9, and CID44216842. Haematologica. 109(7):2092-2110
- Yu, T., Kuang, H., Wu, X., Huang, Y., Wang, J., Wen, Z. (2023) Cell competition for neuron-derived trophic factor controls the turnover and lifespan of microglia. Science advances. 9:eadf9790
- Dai, Y., Wu, S., Cao, C., Xue, R., Luo, X., Wen, Z., Xu, J. (2022) Csf1rb regulates definitive hematopoiesis in zebrafish. Development (Cambridge, England). 149(16)
- Zhao, S., Zhang, A., Zhu, H., Wen, Z. (2022) The ETS transcription factor Spi2 regulates hematopoietic cell development in zebrafish. Development (Cambridge, England). 149(19)
- Avagyan, S., Henninger, J.E., Mannherz, W.P., Mistry, M., Yoon, J., Yang, S., Weber, M.C., Moore, J.L., Zon, L.I. (2021) Resistance to inflammation underlies enhanced fitness in clonal hematopoiesis. Science (New York, N.Y.). 374:768-772
- Bresciani, E., Carrington, B., Yu, K., Kim, E.M.K., Zhen, T., Guzman, V.S., Broadbridge, E., Bishop, K., Kirby, M., Harper, U., Wincovitch, S., Dell'Orso, S., Sartorelli, V., Sood, R., Liu, P.P. (2021) Redundant mechanisms driven independently by RUNX1 and GATA2 for hematopoietic development. Blood advances. 5(23):4949-4962
- Huang, Z., Chen, K., Chi, Y., Jin, H., Li, L., Zhang, W., Xu, J., Zhang, Y. (2021) Runx1 regulates zebrafish neutrophil maturation via synergistic interaction with c-Myb. The Journal of biological chemistry. 296:100272
- Póvoa, V., Rebelo de Almeida, C., Maia-Gil, M., Sobral, D., Domingues, M., Martinez-Lopez, M., de Almeida Fuzeta, M., Silva, C., Grosso, A.R., Fior, R. (2021) Innate immune evasion revealed in a colorectal zebrafish xenograft model. Nature communications. 12:1156
- Ferrero, G., Miserocchi, M., Di Ruggiero, E., Wittamer, V. (2020) A csf1rb mutation uncouples two waves of microglia development in zebrafish. Development (Cambridge, England). 148(1):
- Fraint, E., Feliz Norberto, M., Bowman, T.V. (2020) A novel conditioning-free hematopoietic stem cell transplantation model in zebrafish. Blood advances. 4:6189-6198
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