Genomic Feature
fh261
- ID
- ZDB-ALT-080325-6
- Name
- fh261
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- ENU
- Lab of Origin
- Moens Lab
- Current Source
-
Zebrafish International Resource Center (ZIRC)
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China Zebrafish Resource Center (CZRC) ( order this ) - Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 25: 31422905 (GRCz11) (1) Details
- Nucleotide change
- T/A
- Variant Notes
-
Mutation A376T, R126stop.
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- A>T at position 376 (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Arg>Stop at position 126 (1)
- Flanking Sequence
-
CATTTGGTGTGTCATTGAAGTAAGAGCTGTCATAGCTGTTCCGTCTTCTCGTCTGACACGTTGGGCCCATAAAATCCATCTGGGAAACGAAAAGACACTTTAATCTATATTTATATTGAAAAGAAAATTAAATCAGCAAACACAAGAGATAAAATATTTACAAGCGATCTTTAATTATTCCCATCTTTCTCTTAAATGTTGAAAAATAATGTTGCTGAATTATCCTAAATTACAAAATCAGTGCAAAAAAACAAGTCCAAGTTTATTTGTCCAAGTAAACACTAAACGACTTATGGCTTAGCGACATCACAATTATACTGTAGCTATAGTATGTAAAAGCCTCAGTATATAAAATAAGTTTCTCACCATGCCATCAGAGCAGTTGGATCTCGGACTGGAAGCATCAGAGTCTCCACTGTAATGTTCCAGAACGGGATAGTAGTTATCCTCTTGACTTCTGAGAAGAGCCTGCAGAGACTCGATATAACTAATGGCGTTTC
T/A CAGAATCTCCACTTTGGGCAGCCTCTGGTTCGGGTTGGTGGACGTGCATCTCTTGAGGGTCTCGAAAGCGTCGTTGACCTTGCTCAGTCGCCTCCTCTCCCTCATGGTGGCGGCTTTGCGACGGTCAGCATTGGTAGTTTTTCTCTTGCAAGCTTTGCATGCCCACAGTAGGCACCTGCCGGCCTGATGATGCCCACTGGGCGCCCTCACGTGCTCGTCCTCGATGTGGTGATGCTCGTCGGGTTTGAGCAGGCTCACGTGAACAAGCCTGGGGTCCAAGTCTTCAAAGAAGTGCATGTCGTTGGTGTTGAAGCAAGGGTCGTCGTAGAAGTCATCAGCTGATGGGATGGGGAAGGGGATATCCGACAACTCCATCTTTTTTGTGTTAAAGTTTAAAAAGCAAGAAATGTACTTGAATGTTTCCAAAGTAGTAAATTTGTAAAAAAAATAAAAACCAAAATTAGGAATAGTAAGACAAAGTCCTTCAGATCCCGAAATAA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| myod1fh261/fh261 | Homozygous | ♀+/- ♂+/- | Fig. 4  from Minchin et al., 2013 | Fig. 4 from Minchin et al., 2013 | |
| myod1fh261/fh261 (AB) | Homozygous | ♀+/- ♂+/- | |||
| myod1fh261/+ (AB) | Heterozygous | Unknown | |||
| myf5hu2022/hu2022; myod1fh261/fh261 | Complex | Fig. 4 from Minchin et al., 2013 | |||
| myod1fh261/fh261 + MO1-myf5 | Complex | Fig. 5 from Chen et al., 2014 |
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Supplemental Information
- Genotyping protocol
- None
- Paulissen, E., Martin, B.L. (2022) Myogenic regulatory factors myod and Myf5 are required for dorsal aorta formation and angiogenic sprouting. Developmental Biology. 490:134-143
- Ganassi, M., Badodi, S., Ortuste Quiroga, H.P., Zammit, P.S., Hinits, Y., Hughes, S.M. (2018) Myogenin promotes myocyte fusion to balance fibre number and size. Nature communications. 9:4232
- Row, R.H., Pegg, A., Kinney, B., Farr, G.H., Maves, L., Lowell, S., Wilson, V., Martin, B.L. (2018) BMP and FGF signaling interact to pattern mesoderm by controlling basic helix-loop-helix transcription factor activity. eLIFE. 7
- Roy, S.D., Williams, V.C., Pipalia, T.G., Li, K., Hammond, C.L., Knappe, S., Knight, R.D., Hughes, S.M. (2017) Myotome adaptability confers developmental robustness to somitic myogenesis in response to fibre number alteration. Developmental Biology. 431(2):321-335
- Brunt, L.H., Skinner, R.E., Roddy, K.A., Araujo, N.M., Rayfield, E.J., Hammond, C.L. (2016) Differential effects of altered patterns of movement and strain on joint cell behaviour and skeletal morphogenesis. Osteoarthritis and Cartilage. 24(11):1940-1950
- Brunt, L.H., Norton, J.L., Bright, J.A., Rayfield, E.J., Hammond, C.L. (2015) Finite element modelling predicts changes in joint shape and cell behaviour due to loss of muscle strain in jaw development. Journal of biomechanics. 48(12):3112-22
- Chen, J.W., Galloway, J.L. (2014) The development of zebrafish tendon and ligament progenitors. Development (Cambridge, England). 141:2035-45
- Lin, C.Y., Lee, H.C., Chen, H.C., Hsieh, C.C., and Tsai, H.J. (2013) Normal Function of Myf5 During Gastrulation Is Required for Pharyngeal Arch Cartilage Development in Zebrafish Embryos. Zebrafish. 10(4):486-99
- Minchin, J.E., Williams, V.C., Hinits, Y., Low, S., Tandon, P., Fan, C.M., Rawls, J.F., and Hughes, S.M. (2013) Oesophageal and sternohyal muscle fibres are novel Pax3-dependent migratory somite derivatives essential for ingestion. Development (Cambridge, England). 140(14):2972-2984
- Hinits, Y., Williams, V.C., Sweetman, D., Donn, T.M., Ma, T.P., Moens, C.B., and Hughes, S.M. (2011) Defective cranial skeletal development, larval lethality and haploinsufficiency in Myod mutant zebrafish. Developmental Biology. 358(1):102-12
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