Genomic Feature
sb60
- ID
- ZDB-ALT-071127-4
- Name
- sb60
- Synonyms
-
- steif (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Strähle Lab (Closed)
- Current Source
-
European Zebrafish Resource Center (EZRC)
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Zebrafish International Resource Center (ZIRC) ( order this ) - Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 8: 11207330 (GRCz11) (1) Details
- Nucleotide change
- G/T
- Variant Notes
-
C to A mutation changes the cysteine at position 788 to a stop codon.
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- C>A (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Cys>Stop at position 788 (1)
- Flanking Sequence
-
GGGGCTCGAACCAGTGACCTTCTTGCTGTCAGGCGATTGTGTTAACCAGTATTTAAACTCATACTGGTAACATTTAACACTTTATAAAGCACATAATAAGCATCCAAGGTGATCATTGTCATTGTAGTTTGTGTCGAAGAAATAGAAAAATGAAATATTCACAGATGATCATATTTGCCTCTTACATATCAGAATATTCACCTTCACAGTTGGTCAATCCTACATACAGCACCTTTAAAAGTACATACCACTTTAGTCATCTTAACAGCCAGTTTCTTCTGTGCGGCAGTGAGCATCGCCAGAGCCCCGGCTGCTGCCCTCTGAAGCTTCTCCTCATCCTCACCGCAGAGAAGCACTAGAAGCTTGAGCTTATCGTTGCCGTCTTCCAGATATCTGTCTTGGACCTGTTAAAAGAATCTGCTCAATATTGCCATCCACTTGTAAGAGGCATTTTTTGGTTAGCAGAATGTTGTTCATACCTCCTTGCAGCAAACTAGATT
G/T CACATGCACTCTGTGGCGGCTTGTCTGATCTGTTCATGATCCTCAAACATGTAGTTCTCGATTTCTGGCAGCGCTTTTTCTTTCAGGATTTTTACCCTGTTGAAAGATAAATATGAGGATTAGATTTGTGCTTTACTTTGAAATATTTGTTTAAAGATTTTGGGGTAAGCCAGGGGTGTCCAAACTCGGTTCTGAAGGGCCGGTGTCCTGTATAGTTTAGCTCCAACTGCCTTCAACACGCCTCCCTGGAAGTTTCTAGTATACCTAGAAAAAGCTTGATTAGCTGGTTCAGGTGTGTTTAGTTGGGGTTGGAACTAAAATATGCAGGACACTGGCTCTCCAGGACAGAGTTTGGAAACCCCCGGGTTAAGCATTTGTTTTACTCTACAGTATGATCTTGTAATAGAGGCTTGTAATCTCCTCCAGCCCACTAGAGAAAACCCTAACTAGAAAGTCACCTTTGTTTTACAAATAACTGACTGAAATTTAGTACTTTAGCC - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| unc45bsb60/sb60 | Homozygous | ♀+/- ♂+/- | 12 figures  from 5 publications | 8 figures from 5 publications | |
| unc45bsb60/sb60 | Homozygous | Unknown | 3 figures from Etard et al., 2007 | 2 figures from 2 publications | |
| unc45bsb60/sb60 (AB) | Homozygous | ♀+/- ♂+/- | |||
| unc45bsb60/sb60 (AB, TU) | Homozygous | ♀+/- ♂+/- | 2 figures from Myhre et al., 2014 | 3 figures from Myhre et al., 2014 | |
| unc45bsb60/+ (AB) | Heterozygous | Unknown | |||
| unc45bsb60/sb60; zf13Tg (AB) | Complex | Fig. 7 from Etard et al., 2010 | Fig. 7 from Etard et al., 2010 | ||
| unc45atr12/tr12; unc45bsb60/sb60 | Complex | 4 figures from 2 publications | 4 figures from Comyn et al., 2012 |
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Supplemental Information
- Genotyping protocol
- None
- Prill, K., Carlisle, C., Stannard, M., Windsor Reid, P.J., Pilgrim, D.B. (2019) Myomesin is part of an integrity pathway that responds to sarcomere damage and disease. PLoS One. 14:e0224206
- Paone, C., Rudeck, S., Etard, C., Strähle, U., Rottbauer, W., Just, S. (2018) Loss of zebrafish Smyd1a interferes with myofibrillar integrity without triggering the misfolded myosin response. Biochemical and Biophysical Research Communications. 496(2):339-345
- Armant, O., Gourain, V., Etard, C., Strähle, U. (2016) Whole transcriptome data analysis of zebrafish mutants affecting muscle development. Data in brief. 8:61-8
- Takamiya, M., Xu, F., Suhonen, H., Gourain, V., Yang, L., Ho, N.Y., Helfen, L., Schröck, A., Etard, C., Grabher, C., Rastegar, S., Schlunck, G., Reinhard, T., Baumbach, T., Strähle, U. (2016) Melanosomes in pigmented epithelia maintain eye lens transparency during zebrafish embryonic development. Scientific Reports. 6:25046
- Etard, C., Armant, O., Roostalu, U., Gourain, V., Ferg, M., Strähle, U. (2015) Loss of function of myosin chaperones triggers Hsf1-mediated transcriptional response in skeletal muscle cells. Genome biology. 16:267
- Prill, K., Windsor Reid, P., Wohlgemuth, S.L., Pilgrim, D.B. (2015) Still Heart Encodes a Structural HMT, SMYD1b, with Chaperone-Like Function during Fast Muscle Sarcomere Assembly. PLoS One. 10:e0142528
- Hansen, L., Comyn, S., Mang, Y., Lind-Thomsen, A., Myhre, L., Jean, F., Eiberg, H., Tommerup, N., Rosenberg, T., Pilgrim, D. (2014) The myosin chaperone UNC45B is involved in lens development and autosomal dominant juvenile cataract.. European journal of human genetics : EJHG. 22(11):1290-7
- Myhre, J.L., Hills, J.A., Jean, F., Pilgrim, D.B. (2014) Unc45b is essential for early myofibrillogenesis and costamere formation in zebrafish. Developmental Biology. 390:26-40
- Myhre, J.L., Hills, J.A., Prill, K., Wohlgemuth, S.L., and Pilgrim, D.B. (2014) The titin A-band rod domain is dispensable for initial thick filament assembly in zebrafish. Developmental Biology. 387(1):93-108
- Comyn, S.A., and Pilgrim, D. (2012) Lack of Developmental Redundancy between Unc45 Proteins in Zebrafish Muscle Development. PLoS One. 7(11):e48861
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