Genomic Feature
mi149
- ID
- ZDB-ALT-071121-1
- Name
- mi149
- Synonyms
-
- redhead (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Lyons Lab
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 2: 36628880 (GRCz11) (1) Details
- Nucleotide change
- T/A
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- None
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
ATATTTTTACCGGAAATAGTAAACCATGCGGGAACCTTTGGCACATTCTTTTCAATGTACTATAGTTTCAGTCATACTAATTCTATTTTTGTACACCATTTAAGATGGATAGTATGCAAATTGTGACGCAGCAAATGTTTCTTGTTAACTAATAGCATATTAGAATGATTTCTGACATAAAAATCTGCAATAATGACTACTAAAAATCTGCTGTTATATAAAAAATTGTATTGGCACCTAACATTTAAATAGAAGTGCATTTATTCCAATTAATCGCACCGTTCCAAGCATTTGCATGTTACCACTGTAAATTTACATTCTGAATTATAGTTTTGGCCTTTGTGTTAAAATAGGCAAAGTGAACTGGTAGTGATGTGTTTCTACAGGTTGCTATTAAGCAGATTAACCTACAGAAGCAGCCCAAAAAAGAGCTGATCATCAATGAGATCCTGGTGATGAAGGAGCTGAAGAATCCAAACATTGTCAACTTCTTAGACAGG
T/A AGTTACACCCCTTAAAAAAGTCTTTTTACACAAATTGCATGTACAATTTGTAAAAATAACAGTTAATAATGTATAATTACAAGCAACTTACCCTAATCCAGACCTAACCCTAAAGTAGTAACGTGTACTTATTATTACTCATTTACAAAGGTTATTTTTTGTATCAGGGTGTCACAATCACCAGCTATTCAGGCTGGTAGCTCACTGGGAATCATTCACTTTCACTCAGGACTATCTGTCAACATATGGACTATACATCCTGTCATGCACCACACACTCACACCTGTTCCAGTTTTCCGCTGATTGCTAACACACAGCTGAAGCTGTTCAGAACTGATTACATGGACTTTAAAAGCAGCACAGACACACACACACACACCAGTTTCTGATACTTGTTATATTGTTATTTTGAACATTACAACGGATTTCCCTTGCCTTGTTTTGCCATGTTTTGACTCTCGCCTTGTTTGTTTATTTATGTTGCTTGCTGCTTGTACTGA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| pak2ami149/mi149 | Homozygous | ♀+/- ♂+/- | Fig. 1 from Buchner et al., 2007 | Fig. 2 from Buchner et al., 2007 | |
| pak2ami149/+ | Heterozygous | ♀+/- ♂+/- | Fig. 2 from Buchner et al., 2007 | ||
| pak2ami149/+ (AB) | Heterozygous | Unknown | |||
| pak2ami149/+ (TL) | Heterozygous | Unknown | |||
| pak2ami149/mi149 + MO1-pak2b | Complex | Fig. 4 from Buchner et al., 2007 | |||
| pak2ami149/+ + MO1-pak2b | Complex | Fig. 4 from Buchner et al., 2007 |
1 - 6 of 6
Show
Supplemental Information
- Genotyping protocol
- None
- Thirugnanam, K., Prabhudesai, S., Van Why, E., Pan, A., Gupta, A., Foreman, K., Zennadi, R., Rarick, K.R., Nauli, S.M., Palecek, S.P., Ramchandran, R. (2022) Ciliogenesis mechanisms mediated by PAK2-ARL13B signaling in brain endothelial cells is responsible for vascular stability. Biochemical pharmacology. 202:115143
- Choe, C.P., Crump, J.G. (2015) Eph-Pak2a signaling regulates branching of the pharyngeal endoderm by inhibiting late-stage epithelial dynamics. Development (Cambridge, England). 142(6):1089-94
- Buchner, D.A., Su, F., Yamaoka, J.S., Kamei, M., Shavit, J.A., Barthel, L.K., McGee, B., Amigo, J.D., Kim, S., Hanosh, A.W., Jagadeeswaran, P., Goldman, D., Lawson, N.D., Raymond, P.A., Weinstein, B.M., Ginsburg, D., and Lyons, S.E. (2007) pak2a mutations cause cerebral hemorrhage in redhead zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 104(35):13996-140001
1 - 3 of 3
Show