Genomic Feature
hi3093Tg
- ID
- ZDB-ALT-050809-14
- Name
- hi3093Tg
- Synonyms
-
- hi3093 (1)
- Affected Genomic Region
- Construct
- Type
- Allele caused by Transgenic insertion (1)
- Protocol
- embryos treated with DNA
- Lab of Origin
- Hopkins Lab
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
| Comment | Citation |
|---|---|
| The construct was inserted on the plus strand of the genome. The gene in which ... | ZFIN Curated Data |
Variants
- Variant Type
- Transgenic Insertion
- Variant Location
- Chr 10: 6121789 - 6121790 (GRCz11) (1) Details
- Nucleotide change
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- Insertion in Intron 1 (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
- None
- Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| tln1hi3093Tg/hi3093Tg | Homozygous | ♀+/- ♂+/- | 4 figures  from 3 publications | Fig. 2 from Wu et al., 2015 | |
| tln1hi3093Tg/+ (AB) | Heterozygous | Unknown | |||
| tln1hi3093Tg/+ (AB/TU) | Heterozygous | Unknown | |||
| tln1hi3093Tg | Unknown | Unknown | Fig. for (hi3093) from Phenotype Annotation (1994-2006) | ||
| tln1hi3093Tg/hi3093Tg; cz3327Tg | Complex | Fig. 5 from Ishii et al., 2018 | |||
| tln1hi3093Tg/hi3093Tg; is5Tg | Complex | Fig. 5 from James et al., 2016 | Fig. 5 from James et al., 2016 | ||
| tln1hi3093Tg/hi3093Tg; pku316Tg | Complex | Fig. 5 from Wu et al., 2015 | |||
| tln1hi3093Tg/hi3093Tg; y1Tg | Complex | ||||
| tln1hi3093Tg/hi3093Tg; zf393Tg | Complex | Fig. 3 from Ishii et al., 2018 | |||
| tln1hi3093Tg/hi3093Tg; zf595Tg | Complex | Fig. 3 from Ishii et al., 2018 |
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Supplemental Information
- Genotyping protocol
- hi3093tg.pdf
- Gunawan, F., Gentile, A., Fukuda, R., Tsedeke, A.T., Jiménez-Amilburu, V., Ramadass, R., Iida, A., Sehara-Fujisawa, A., Stainier, D.Y.R. (2019) Focal adhesions are essential to drive zebrafish heart valve morphogenesis. The Journal of cell biology. 218(3):1039-1054
- Ishii, K., Mukherjee, K., Okada, T., Liao, E.C. (2018) Genetic Requirement of talin1 for Proliferation of Cranial Neural Crest Cells during Palate Development.. Plastic and reconstructive surgery. Global open. 6:e1633
- James, A., Lee, C., Williams, A.M., Angileri, K., Lathrop, K.L., Gross, J.M. (2016) The Hyaloid Vasculature Facilitates Basement Membrane Breakdown During Choroid Fissure Closure in the Zebrafish Eye. Developmental Biology. 419(2):262-272
- Wu, Q., Zhang, J., Koh, W., Yu, Q., Zhu, X., Amsterdam, A., Davis, G.E., Arnaout, M.A., Xiong, J.W. (2015) Talin1 is required for cardiac Z-disk stabilization and endothelial integrity in zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 29(12):4989-5005
- Zhang, G., Hoersch, S., Amsterdam, A., Whittaker, C.A., Beert, E., Catchen, J.M., Farrington, S., Postlethwait, J.H., Legius, E., Hopkins, N., and Lees, J.A. (2013) Comparative oncogenomic analysis of copy number alterations in human and zebrafish tumors enables cancer driver discovery. PLoS Genetics. 9(8):e1003734
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