Gene
tln1
- ID
- ZDB-GENE-031002-48
- Name
- talin 1
- Symbol
- tln1 Nomenclature History
- Previous Names
-
- sb:cb854
- wu:fb05c02
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable integrin binding activity. Acts upstream of or within several processes, including embryonic organ morphogenesis; skeletal muscle tissue development; and striated muscle cell development. Predicted to be located in cytoskeleton and ruffle. Predicted to be active in cytoplasm; focal adhesion; and plasma membrane. Is expressed in several structures, including adaxial cell; cardiovascular system; cranium; musculature system; and nervous system. Orthologous to human TLN1 (talin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb854 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- 19 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019747 | FERM conserved site |
| Domain | IPR000299 | FERM domain |
| Domain | IPR002404 | IRS-type PTB domain |
| Domain | IPR002558 | I/LWEQ domain |
| Domain | IPR015009 | Vinculin-binding site-containing domain |
| Domain | IPR015224 | Talin, central |
| Domain | IPR019748 | FERM central domain |
| Domain | IPR019749 | Band 4.1 domain |
| Domain | IPR032425 | Talin, N-terminal F0 domain |
| Domain | IPR037438 | Talin-1/2, rod-segment |
| Domain | IPR049108 | Talin, R4 domain |
| Domain | IPR054060 | Talin 1-like, rod-segment domain |
| Domain | IPR054082 | Talin, IBS2B domain |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR014352 | FERM/acyl-CoA-binding protein superfamily |
| Homologous_superfamily | IPR035963 | FERM superfamily, second domain |
| Homologous_superfamily | IPR035964 | I/LWEQ domain superfamily |
| Homologous_superfamily | IPR036476 | Talin, central domain superfamily |
| Homologous_superfamily | IPR036723 | Alpha-catenin/vinculin-like superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Alpha-catenin/vinculin-like superfamily | Band 4.1 domain | FERM/acyl-CoA-binding protein superfamily | FERM central domain | FERM conserved site | FERM domain | FERM superfamily, second domain | I/LWEQ domain | I/LWEQ domain superfamily | IRS-type PTB domain | PH-like domain superfamily | Talin-1/2, rod-segment | Talin 1-like, rod-segment domain | Talin, central | Talin, central domain superfamily | Talin, IBS2B domain | Talin, N-terminal F0 domain | Talin, R4 domain | Vinculin-binding site-containing domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PTJ3 | InterPro | 2561 | |||||||||||||||||||
| UniProtKB:A0A8M2B1K5 | InterPro | 2560 | |||||||||||||||||||
| UniProtKB:Q5U7N6 | InterPro | 2538 | |||||||||||||||||||
| UniProtKB:A0A8M9Q646 | InterPro | 2542 | |||||||||||||||||||
| UniProtKB:A0A8M2B1Z7 | InterPro | 2541 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available