Genomic Feature
vu44
- ID
- ZDB-ALT-050309-2
- Name
- vu44
- Synonyms
-
- mut44 (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- Lab of Origin
- Lila Solnica-Krezel Lab - Vanderbilt University
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 7: 53100415 (GRCz11) (1) Details
- Nucleotide change
- A/T
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>A (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Leu>Stop at position 553 (1)
- Flanking Sequence
-
TTCACCCTCCCGATCAGCAACTCTCAGGACCACCTTGTATTCACCCTGTTCCAACTGAGATTGAGGCTTGATATTCAGAAAATGACCAGTTTCTATAATTGGCAAATGTAATAGTTAGAGATGTCCACTCAAAGTCAGATGAACTATATATATATATATAAAATAAAACAAACATTTACTCACCATTGAAAAAAACAGACCAATTTTTACTGGTATCACCTTGGGGCTCAACTTTGAAGGGACCAGCAAAAGGAGGTAAATCTTTGTCCGTTATAGAGAGAAGCACTGGGGCTGATTCACGATTGCACAATTTTATGGTCCTTTCATTAATAACAGGAGCATTGTCATTTACATCCTGCAGTTCAATTACCAGTGTTCCTGTGCCAGTTGCTGGAGACTCAACTGCAAACAACATTTGTTCAAAGATTAGACAAAAAACAAATAACTAAAAATCTAGACAGGAACTTTAAGAAAAATAAAATACTCTACCATCATTATCC
A/T AAGCCAAAATGAGAGCTTTGTATTTGCCATCTTTGACATTGGAAGATTCTCGATCCAAAGCATTCTTGACTTGAATCTGCCCAGAGCCTGTTATATTGAGCCAGTCAGAAGGATCATTTCCAATTCTATAACTGTAAGGAGCCAAAACATACAGGTTAAATGCTAAGCAAGAACTATGCAGTGTTATTTTACATTTAATTATCTGTACCTAAATACTGTTAAACTCCCCAAGAAACCATAAAGCACTGTTTATTTACTTCCTTTGGTCAATTGTATTGATCTAGGCTTGCAATTTGTTTAATTTTATGCACAATTTCCCAACAAAGTCATCCCAAATAATCTAAATCAATGAATTCCTTCCAAACAAAGCTCCAAGCCATCTGGTAAAATTACAATCATATCGCAACATATATTGCAAAAAAATAAAAGATAAACAATTTCACAATGTCAGATTTGTAATCTACTGGAAAAGGCTAGATGGTTATCAGGCTGCTACGCAA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| cdh1vu44/vu44 | Homozygous | ♀+/- ♂+/- | Fig. 6 from Lin et al., 2009 |
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Supplemental Information
- Genotyping protocol
- None
- Li, C., Ma, H., Wang, Y., Cao, Z., Graves-Deal, R., Powell, A.E., Starchenko, A., Ayers, G.D., Washington, M.K., Kamath, V., Desai, K., Gerdes, M.J., Solnica-Krezel, L., Coffey, R.J. (2014) Excess PLAC8 promotes an unconventional ERK2-dependent EMT in colon cancer. J. Clin. Invest.. 124(5):2172-87
- Lin, F., Chen, S., Sepich, D.S., Panizzi, J.R., Clendenon, S.G., Marrs, J.A., Hamm, H.E., and Solnica-Krezel, L. (2009) Galpha12/13 regulate epiboly by inhibiting E-cadherin activity and modulating the actin cytoskeleton. The Journal of cell biology. 184(6):909-921
- Kane, D.A., McFarland, K.N., and Warga, R.M. (2005) Mutations in half baked/E-cadherin block cell behaviors that are necessary for teleost epiboly. Development (Cambridge, England). 132(5):1105-1116
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