Genomic Feature
b926
- ID
- ZDB-ALT-040930-24
- Name
- b926
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- ENU
- Lab of Origin
- Kimmel Lab
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 23: 33501388 (GRCz11) (1) Details
- Nucleotide change
- A/T
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>A at position 952 (1)
- Transcript Consequence
- Missense (1)
- Protein Consequence
- Amino Acid Substitution: Tyr>Asn at position 218 (1)
- Flanking Sequence
-
AACGGCAAATAAAAAACTATTAAAATAAAATGTTAATAAAACAAAGACCCATATTTGGGACTAATTTAAATAACTAAAAGTTTAATTTACATTGACTTTGAATTGTACAGATCTATAGGATTTTGTGTACTCGGGTATTTAAGTAATTAAATTAAGACAGGGTAAAAAGAACATTTCTTTAAAGACTTTAATTTTAATTTTATATTAATATTTATATTTTTTAATTATGTAATTAGTAATTCCTAACTTTCTTAAGTAACCTCAATCCTTTAATTTACGTTCATAACGCTCACCTTCATCATCATCACCGGTAAACTCGCCCACAGCCACTGAATAACCTGTTCAACATGAAAAAATGTGGTCAGTGACAACAGAGAAAAGTTCCTGTGATAAGAAAATAATATACATTTTATGACTGCACATACCCATGTAGGTGTCATCAAATCTGATCTCTTTTCTCTGTTTGGTCTGGATCTGGCCACCCACTGAGGTCAAGAAGT
A/T TCCTGGGTAATAGGCTTTGACAATTTCTTGTTTGAACGCAGTGATTACTTGGCCTAGAGATGGTAGGAAAATATTGATCTTTAATTGCGTTTACATTGAGCTGAAGGTCACAGTCAATGCAAATAATGAATGTGCACGTCTATAAGAACTGATGGAAAACTGGTCCAATTATGAAACTCATACACATCTACCATTCAATATTTCATGGTCAATATTTTGAAGTCTCACATGCTCTAAATTAGGAATATTTAACCCTTGTATATTTTTCAAATGTACTACAATTCTGTTATGTTGGTTGATGTTTTTTGGCCCCATTGACATCAATTATAACCACATTTGTTGATTGCAAAGCCATGACAGCATATAATCCTGCATTCTTGATTGTTGGTGCTTTTTCCTGTTGGGAAGAGGTAAAATGTGTAAGTTTTGCCATTTATCATCAGTTGGCACCATAAACCCTCTAAAAGGCCTGTGTAGAAATGTTACAGGTTTTTATATGA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| itga5b926/b926 | Homozygous | ♀+/- ♂+/- | Fig. 2 from LaMonica et al., 2015 | Fig. S1 from LaMonica et al., 2015 | |
| itga5b926/b926 (AB) | Homozygous | Unknown | Fig. for (b926) from Phenotype Annotation (1994-2006) | text only from Crump et al., 2004 | |
| itga5b926/+ (AB) | Heterozygous | Unknown | |||
| itga5b926/b926; prdm1am805/m805 | Complex | Fig. 2 from LaMonica et al., 2015 |
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Supplemental Information
- Genotyping protocol
- b926.pdf
- LaMonica, K., Ding, H.L., Artinger, K.B. (2015) prdm1a functions upstream of itga5 in zebrafish craniofacial development. Genesis (New York, N.Y. : 2000). 53(3-4):270-7
- Bhat, N., and Riley, B.B. (2011) Integrin-α5 Coordinates Assembly of Posterior Cranial Placodes in Zebrafish and Enhances Fgf-Dependent Regulation of Otic/Epibranchial Cells. PLoS One. 6(12):e27778
- Crump, J.G., Swartz, M.E., Eberhart, J.K., and Kimmel, C.B. (2006) Moz-dependent Hox expression controls segment-specific fate maps of skeletal precursors in the face. Development (Cambridge, England). 133(14):2661-9
- Crump, J.G., Swartz, M.E., and Kimmel, C.B. (2004) An Integrin-Dependent Role of Pouch Endoderm in Hyoid Cartilage Development. PLoS Biology. 2(9):E244
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