Genomic Feature
p50ada
- ID
- ZDB-ALT-030805-10
- Name
- p50ada
- Synonyms
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Mullins Laboratory
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 2: 26294385 (GRCz11) (1) Details
- Nucleotide change
- C/T
- Variant Notes
-
p50ada is a C to T transversion , converting Gln 254 to a stop codon.
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- C>T (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- at position 254 (1)
- Flanking Sequence
-
ATGCGGTCCAGACAGGAGGCATGTCTTTGGCTGCTATTGATGGAGCAGGCATGGGGAGCCAGAGCCCTGTGCTGAGAGTTATTGTAGAAAATCTCTTCTATCCAGTCACTCTTGATGTCCTTCATCAGGTACTGACTGTCCTTCAGAAACCAAATTGAGTGTTTAAATGTATGCATATTTAATGTCTATGTAATGTTAATAGATTTAATTACTTAATGTTTAATTTATAATGTAAATATATTTTAATGTTGCCATTTAAATTGTTACCATTTTTTTCCCCATTTAGATCTTTTCAAAGTTTGGCACCGTTTTGAAGATCATAACCTTTACCAAAAACAACCAGTTTCAAGCTCTGGTTCAATACTCAGACGGAATGACAGCTCAGCATGCAAAGCTGGTGAGTGGCACAGTGGATCAATATATGAATGGATGAATGGGCAGCTAAATCCCTTCTGAACCTTGTAATCATTTGGCTTAACATTAAACAGTCTTTAGATGGA
C/T AGAACATCTACAATGCCTGCTGTACCCTTCGCATCAGTTTCTCTAAGCTCACCAGCCTGAATGTTAAGTACAACAATGATAAGAGCAGAGACTACACTCGCCCCGACCTGCCAACAGGAGACAGTCAGCCCTCCTTTGATGCACAGACAATGGCAGCAGCCGCCTTGAGTAAATTTGATTATTATTGCTGTAGTTAAATGATATACTTAACATATAAAATAACAAACTGCTTTCTCTCTCTTAGCTGCTCCTGGTATTATCTCTGCATCACCTTATGCTGGAGCTCATGGTTTCCCACAAGCATTTGCTATTCAGCAGGCAGCAGGTCAGTCATGGCTTTAATAGGGTCTTTTTTTTTTTCTTTTTTTTTTTTGGCATAATTCACAATGAGTCTGATCTTTAATTGCTGTTCCTTGTACACCTCTAAATCCAACACCAATTTTTTTGTGGGGGCTATGGGATCAGCCTCAACGGCCACTTGCCTTCCAAGGCACATCATC - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| ptbp1ap50ada/p50ada (AB) | Homozygous | ♀+/- ♂+/- | 5 figures  from Yang et al., 2009 | Fig. 4 from Yang et al., 2009 | |
| ptbp1ap50ada/p50ada (TU) | Homozygous | ♀+/- ♂+/- | 5 figures from Yang et al., 2009 | Fig. 4 from Yang et al., 2009 | |
| ptbp1ap50ada/p50ada (WIK) | Homozygous | ♀+/- ♂+/- | text only from Yang et al., 2009 | ||
| ptbp1ap50ada/+ | Heterozygous | Unknown | |||
| ptbp1ap50ada/+ (AB) | Heterozygous | Unknown | |||
| ptbp1ap50ada | Unknown | ♀-/- | 5 figures from Mei et al., 2009 | 3 figures from Mei et al., 2009 | |
| ptbp1ap50ada (AB/TU) | Unknown | Unknown | Fig. for (p50ada) from Phenotype Annotation (1994-2006) |
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Supplemental Information
- Genotyping protocol
- None
- Mei, W., Lee, K.W., Marlow, F.L., Miller, A.L., and Mullins, M.C. (2009) hnRNP I is required to generate the Ca2+ signal that causes egg activation in zebrafish. Development (Cambridge, England). 136(17):3007-3017
- Yang, J., Chan, C.Y., Jiang, B., Yu, X., Zhu, G.Z., Chen, Y., Barnard, J., and Mei, W. (2009) hnRNP I Inhibits Notch Signaling and Regulates Intestinal Epithelial Homeostasis in the Zebrafish. PLoS Genetics. 5(2):e1000363
- Dosch, R., Wagner, D.S., Mintzer, K.A., Runke, G., Wiemelt, A.P., and Mullins, M.C. (2004) Maternal Control of Vertebrate Development before the Midblastula Transition; Mutants from the Zebrafish I. Developmental Cell. 6(6):771-780
- Wagner, D.S., Dosch, R., Mintzer, K.A., Wiemelt, A.P., and Mullins, M.C. (2004) Maternal Control of Development at the Midblastula Transition and beyond; Mutants from the Zebrafish II. Developmental Cell. 6(6):781-790
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