Gene

ptbp1a

ID

ZDB-GENE-050522-492

Name

polypyrimidine tract binding protein 1a

Symbol

ptbp1a Nomenclature History

Previous Names

brb
ptbp1
brom bones (1)
hnRNP I (1)
wu:fb99f12
zgc:110689

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to have mRNA binding activity. Involved in several processes, including intestinal epithelial structure maintenance; negative regulation of Notch signaling pathway; and positive regulation of cortical granule exocytosis by positive regulation of cytosolic calcium ion concentration. Predicted to localize to nucleus. Orthologous to human PTBP1 (polypyrimidine tract binding protein 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 11 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ptbp1a Human Ortholog

No data available

Associated With ptbp1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000504	RNA recognition motif domain
Domain	IPR021790	PTBP1-like, RNA recognition motif 2
Domain	IPR035000	PTBP1, RNA recognition motif 1
Domain	IPR035001	PTBP1, RNA recognition motif 3
Family	IPR006536	HnRNP-L/PTB
Homologous_superfamily	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily
Homologous_superfamily	IPR035979	RNA-binding domain superfamily