Genomic Feature
fov01b
- ID
- ZDB-ALT-010621-6
- Name
- fov01b
- Synonyms
-
- fov1b (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- Lab of Origin
- The Fishman Laboratory
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 8: 54285961 (GRCz11) (1) Details
- Nucleotide change
- C/A
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- C>A (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Tyr>Stop at position 318 (1)
- Flanking Sequence
-
GAGCACCGTCGGCCTGGTGTTCCGCACTCACGGCGGCGCCCCGCGGCTGCTGGTGGGCGCCACATACACCGGCATGGGCACCGAGTACTTCCCCAAGAACCACAGCAAAGAGGACCTGCGCTTCGAGAACACCCCGGAGATCGCCATCCGCGCGCTGGACACGCGCGAGCTCGGCCGCCTCTTCACCTACGACATCAACCCGTCCGAGGACAACGTCTTCAAGATCAAGCAGGAGGTCAAGCAGAAGAACAAGCTGAGCTTCGTGCACGCGTTCGCGCTCGGGAACTACTCCTACATCGCCTTCAACAACGACGCGAACAGCGGGCTGAAGGAGAGCCAGCCGAACAGCGNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNCGCAAGCTAACCGAGTCGTACGCGCAGATGGGGCTCCGGTGCGGCGCCTA
C/A ACCCGCCTGCTGTCCGTCAGCCCGGCGGAGCTGCGCGCGGAGACGTTCCTGTTCGCGGTGTTCGGGCGCGCGGGCGGGCGCGCGGCGGTGTGCGTGTTCCGCGTGGCCGAGGTGGAGGAGATGATCCGGCAGGGCCGCAGGAACTGCTCTCACGGGCCGAACAGCGATGTGCAGGTGCTGGACAGCGTCATCCAGGGCTCCGGGGCCGAGTGCGAGGGCAAGGGCAGCATCATGGTGAGACCCGCGGACAGCGGCATTACCTCCGATTATACATAGACTACTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATGTGTGTGTGTGTGCTGAGAGCAGGAGAGCTGCTGGCTCGATTCTAGCTGAAATGTCTGTATTCTTAAATCTAGAAGCGCTGTCTAGAGCAGTGAAACACATGATGGTGAAGTCTAGATTAAACTCAGCTCAGACTGATCATGTCCACTGCTCCTGGAGCGGGTCAGGAGATT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| plxnd1fov01b/fov01b | Homozygous | Unknown | 4 figures  from 2 publications | ||
| plxnd1fov01b/fov01b | Homozygous | ♀+/- ♂+/- | Fig. 3 from Torres-Vazquez et al., 2004 | 3 figures from 2 publications | |
| plxnd1fov01b/+ (AB) | Heterozygous | ♀+/- ♂+/- | |||
| plxnd1fov01b/+ (TL) | Heterozygous | Unknown | |||
| plxnd1fov01b/fov01b; jh11Tg | Complex | Fig. 6 from Zygmunt et al., 2011 | Fig. 6 from Zygmunt et al., 2011 | ||
| plxnd1fov01b/fov01b; la116Tg | Complex | Fig. 2 from Lamont et al., 2009 | Fig. 2 from Lamont et al., 2009 | ||
| plxnd1fov01b/fov01b; nkuasrfp1aTg; ubs4Tg; y1Tg | Complex | ||||
| plxnd1fov01b/fov01b; s896Tg (EKW) | Complex | ||||
| plxnd1fov01b/fov01b; y1Tg | Complex | 3 figures from 2 publications | Fig. 1 from Zygmunt et al., 2011 | ||
| plxnd1fov01b/fov01b; y1Tg (EKW) | Complex | 3 figures from Minchin et al., 2015 | 2 figures from Minchin et al., 2015 |
1 - 10 of 22
Show
Supplemental Information
- Genotyping protocol
- None
- Britto, D.D., He, J., Misa, J.P., Chen, W., Kakadia, P.M., Grimm, L., Herbert, C.D., Crosier, K.E., Crosier, P.S., Bohlander, S.K., Hogan, B.M., Hall, C.J., Torres-Vázquez, J., Astin, J.W. (2022) Plexind1 negatively regulates zebrafish lymphatic development. Development (Cambridge, England). 149(21)
- Carretero-Ortega, J., Chhangawala, Z., Hunt, S., Narvaez, C., Menéndez-González, J., Gay, C.M., Zygmunt, T., Li, X., Torres-Vázquez, J. (2019) GIPC proteins negatively modulate Plexind1 signaling during vascular development. eLIFE. 8:
- Goi, M., Childs, S.J. (2016) Patterning Mechanisms of the Sub-Intestinal Venous Plexus in Zebrafish. Developmental Biology. 409(1):114-28
- Minchin, J.E., Dahlman, I., Harvey, C.J., Mejhert, N., Singh, M.K., Epstein, J.A., Arner, P., Torres-Vazquez, J., Rawls, J.F. (2015) Plexin D1 determines body fat distribution by regulating the type V collagen microenvironment in visceral adipose tissue. Proceedings of the National Academy of Sciences of the United States of America. 112(14):4363-8
- Zygmunt, T., Gay, C.M., Blondelle, J., Singh, M.K., Flaherty, K.M., Means, P.C., Herwig, L., Krudewig, A., Belting, H.G., Affolter, M., Epstein, J.A., and Torres-Vazquez, J. (2011) Semaphorin-PlexinD1 Signaling Limits Angiogenic Potential via the VEGF Decoy Receptor sFlt1. Developmental Cell. 21(2):301-314
- Lamont, R.E., Lamont, E.J., and Childs, S.J. (2009) Antagonistic interactions among Plexins regulate the timing of intersegmental vessel formation. Developmental Biology. 331(2):199-209
- Alvarez, Y., Cederlund, M.L., Cottell, D.C., Bill, B.R., Ekker, S.C., Torres-Vazquez, J., Weinstein, B.M., Hyde, D.R., Vihtelic, T.S., and Kennedy, B.N. (2007) Genetic determinants of hyaloid and retinal vasculature in zebrafish. BMC Developmental Biology. 7(1):114
- Torres-Vazquez, J., Gitler, A.D., Fraser, S.D., Berk, J.D., Pham, V.N., Fishman, M.C., Childs, S., Epstein, J.A., and Weinstein, B.M. (2004) Semaphorin-plexin signaling guides patterning of the developing vasculature. Developmental Cell. 7(1):117-123
- Childs, S., Chen, J.-N., Garrity, D.M., and Fishman, M.C. (2002) Patterning of angiogenesis in the zebrafish embryo. Development (Cambridge, England). 129(4):973-982
1 - 9 of 9
Show