PUBLICATION

Semaphorin-plexin signaling guides patterning of the developing vasculature

Authors
Torres-Vazquez, J., Gitler, A.D., Fraser, S.D., Berk, J.D., Pham, V.N., Fishman, M.C., Childs, S., Epstein, J.A., and Weinstein, B.M.
ID
ZDB-PUB-040709-6
Date
2004
Source
Developmental Cell   7(1): 117-123 (Journal)
Registered Authors
Childs, Sarah J., Fishman, Mark C., Fraser, Sherri, Pham, Van, Torres-Vázquez, Jesús, Weinstein, Brant M.
Keywords
none
MeSH Terms
  • Animals
  • Blood Vessels/cytology
  • Blood Vessels/embryology*
  • Blood Vessels/metabolism
  • Body Patterning/genetics*
  • Cell Line
  • Gene Expression Regulation, Developmental/genetics
  • Humans
  • Membrane Glycoproteins/genetics
  • Membrane Glycoproteins/isolation & purification
  • Membrane Glycoproteins/metabolism
  • Mice
  • Molecular Sequence Data
  • Mutation/genetics
  • Neovascularization, Physiologic/genetics*
  • Nerve Tissue Proteins/genetics
  • Receptors, Cell Surface/genetics
  • Receptors, Cell Surface/isolation & purification
  • Receptors, Cell Surface/metabolism*
  • Semaphorins/genetics
  • Semaphorins/metabolism*
  • Signal Transduction/genetics
  • Signal Transduction/physiology
  • Somites/cytology
  • Somites/metabolism
  • Zebrafish
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/isolation & purification
  • Zebrafish Proteins/metabolism*
(all 29)
PubMed
15239959 Full text @ Dev. Cell
Abstract
Major vessels of the vertebrate circulatory system display evolutionarily conserved and reproducible anatomy, but the cues guiding this stereotypic patterning remain obscure. In the nervous system, axonal pathways are shaped by repulsive cues provided by ligands of the semaphorin family that are sensed by migrating neuronal growth cones through plexin receptors. We show that proper blood vessel pathfinding requires the endothelial receptor PlexinD1 and semaphorin signals, and we identify mutations in plexinD1 in the zebrafish vascular patterning mutant out of bounds. These results reveal the fundamental conservation of repulsive patterning mechanisms between axonal migration in the central nervous system and vascular endothelium during angiogenesis.
Genes / Markers
Figures
No images available
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Expression
Phenotype
Mutations / Transgenics
Allele Construct Type Affected Genomic Region
fov01b
    Point Mutation
    fs31l
      Deficiency
      y1TgTransgenic Insertion
        1 - 3 of 3
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        Human Disease / Model
        No data available
        Sequence Targeting Reagents
        Target Reagent Reagent Type
        plxnd1MO1-plxnd1MRPHLNO
        plxnd1MO2-plxnd1MRPHLNO
        sema3aaMO4-sema3aaMRPHLNO
        sema3abMO2-sema3abMRPHLNO
        1 - 4 of 4
        Show
        Fish
        Antibodies
        Orthology
        Gene Orthology
        plxnd1
        rho
        1 - 2 of 2
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        Engineered Foreign Genes
        No data available
        Mapping
        Entity Type Entity Symbol Location
        fs31lChr: 8 Details
        GENEbrpf1Chr: 8 Details
        GENEplxnd1Chr: 8 Details
        GENErhoChr: 8 Details
        SSLPz9637Chr: 8 Details
        SSLPz53435Chr: 8 Details
        1 - 6 of 6
        Show