Genomic Feature
b781
- ID
- ZDB-ALT-001213-2
- Name
- b781
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Westerfield Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 9: 28919126 (GRCz11) (1) Details
- Nucleotide change
- G/A
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- C>T at position 424 (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Gln>Stop at position 142 (1)
- Flanking Sequence
-
TCAGACTTTTGAAAAGCAGTTTAATTCACTGTAATTACTGTTGCTTACCTTGTAGAGCATAGGAAGCCAACTCCACGGTTGTGTCGAATGGGCATTCTAGCCTAGAGTAAACAAAATCAAGTCTATTTAGACCAGAGGTATCCACACTCAGTCCAGGAGGGCAGTTGTCCTGCATAGTTTAGCTCCAATTTCCTTCAACACACCAGCCTTGAAGTTTCTAGTATACCCAGAATAAGCTTTATTAGCTGCTTCATTTGTGTTTAATTGGGGTTGGAACTAAAATATGCAGGACACTGGCCCTTCAGGACCAAGTTTGGGAACCACTGATTTTGACAATTTCTAAACGTATATCAGCTATCAAAAACCATAATAGTTTGAAAGGACATTTCATTTCTCAAATTTAAAATGGCAAAAGACAACAATGTCAATATTCTTTCCACACAATTTAACTCTAATCTTAAACTTCACTTACTTGCCACTGAGAATGTCCTGCTTTAACT
G/A TAGAACAAAAAGGTATCTACAACAAATAATAAAGATAAAATGAGTGCAAAAATAATCAAGCGAATATTAGTTGTGTTTATGGCATAAACGGAGAATTAACCTTGTTAGCTCTTCATGCAAGTTGTTGGGCTCAGAGGAGTAGAATTTTACTCTCATATGGAGGCAATACGGTGGACCAACTGAAAGGCAGACAATACCAAATGAAATATTCAAAGCAAAACTGCTTACTAGAAGTGTGAGTTTGTACTGCACAAGTGTCAAGTTTGCTTTGGTATGTTTTAACACAGAACACTGCATAATAAAATAGGAATTTTAGACAGAATGCCATACAAGTGATGAGATACAGAGACTTTCCACTTCATGGTTTATTATTACCCGCCTTTCACAGACAGAGTTAAGCATTAACCATGTACTTATGAAAGTAGTCACAAAGACTAGTTAAAATGTTGCCCCGTTCTAAACCTTTGCTGCCTACTAGAGCTGTGCTATTTAGCTTTTAG - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| epb41l5b781/b781 | Homozygous | Unknown | 2 figures from 2 publications | ||
| epb41l5b781/b781 | Homozygous | ♀+/- ♂+/- | 6 figures  from 3 publications | 3 figures from 2 publications | |
| epb41l5b781/b781; fl1Tg | Complex | 3 figures from Christensen et al., 2008 | 3 figures from Christensen et al., 2008 | ||
| epb41l5b781/b781; fl1Tg | Complex |
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Supplemental Information
- Genotyping protocol
- None
- Beyer, J., Zhao, X.C., Yee, R., Khaliq, S., McMahon, T.T., Ying, H., Yue, B.Y., and Malicki, J.J. (2010) The role of crumbs genes in the vertebrate cornea. Investigative ophthalmology & visual science. 51(9):4549-4556
- Christensen, A.K., and Jensen, A.M (2008) Tissue-specific requirements for specific domains in the FERM protein Moe/Epb4.1l5 during early zebrafish development. BMC Developmental Biology. 8:3
- Bagnat, M., Cheung, I.D., Mostov, K.E., and Stainier, D.Y. (2007) Genetic control of single lumen formation in the zebrafish gut. Nature cell biology. 9(8):954-960
- Hsu, Y.C., Willoughby, J.J., Christensen, A.K., and Jensen, A.M. (2006) Mosaic Eyes is a novel component of the Crumbs complex and negatively regulates photoreceptor apical size. Development (Cambridge, England). 133(24):4849-4859
- Omori, Y., and Malicki, J. (2006) oko meduzy and Related crumbs Genes Are Determinants of Apical Cell Features in the Vertebrate Embryo. Current biology : CB. 16(10):945-957
- Jensen, A.M., and Westerfield, M. (2004) Zebrafish Mosaic Eyes Is a Novel FERM Protein Required for Retinal Lamination and Retinal Pigmented Epithelial Tight Junction Formation. Current biology : CB. 14(8):711-717
- Tsujikawa, M., and Malicki, J. (2004) Genetics of photoreceptor development and function in zebrafish. The International journal of developmental biology. 48(8-9):925-934
- Jensen, A.M., Walker, C., and Westerfield, M. (2001) mosaic eyes: a zebrafish gene required in pigmented epithelium for apical localization of retinal cell division and lamination. Development (Cambridge, England). 128(1):95-105
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