Gene

epb41l5

ID

ZDB-GENE-030616-450

Name

erythrocyte membrane protein band 4.1 like 5

Symbol

epb41l5 Nomenclature History

Previous Names

moe
mosaic eyes
si:dz104f18.2
si:dz104f18.3
si:dz37o5.2

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to have cytoskeletal protein binding activity. Involved in several processes, including animal organ development; maintenance of epithelial cell apical/basal polarity; and positive regulation of Notch signaling pathway. Localizes to bicellular tight junction and protein-containing complex. Used to study proteinuria. Is expressed in integument; nervous system; and pronephros. Orthologous to human EPB41L5 (erythrocyte membrane protein band 4.1 like 5).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 6 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 15 figures from 8 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With epb41l5 Human Ortholog

No data available

Associated With epb41l5 Via Experimental Models

Human Disease	Fish	Conditions	Citations
proteinuria	epb41l5^b882/b882 (TU)	standard conditions	Kramer-Zucker et al., 2005

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019747	FERM conserved site
Domain	IPR000299	FERM domain
Domain	IPR014847	FERM adjacent
Domain	IPR018979	FERM, N-terminal
Domain	IPR018980	FERM, C-terminal PH-like domain
Domain	IPR019748	FERM central domain
Domain	IPR019749	Band 4.1 domain
Family	IPR000798	Ezrin/radixin/moesin-like
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR014352	FERM/acyl-CoA-binding protein superfamily
Homologous_superfamily	IPR029071	Ubiquitin-like domain superfamily
Homologous_superfamily	IPR035963	FERM superfamily, second domain

Domain Details Per Protein

Protein	Length	Band 4.1 domain	Ezrin/radixin/moesin-like	FERM/acyl-CoA-binding protein superfamily	FERM adjacent	FERM central domain	FERM conserved site	FERM, C-terminal PH-like domain	FERM domain	FERM, N-terminal	FERM superfamily, second domain	PH-like domain superfamily	Ubiquitin-like domain superfamily
UniProtKB:Q6NYK4 InterPro	772

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	epb41l5-002 (1)	Havana	2,557 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	epb41l5-201 (1) Ensembl	Ensembl	5,070 nt	Select Tool ZFIN BLAST
mRNA	epb41l5-202 (1) Ensembl	Ensembl	4,081 nt	Select Tool
mRNA	epb41l5-203 (1) Ensembl	Ensembl	2,331 nt	Select Tool
mRNA	epb41l5-204 (1) Ensembl	Ensembl	1,939 nt	Select Tool
mRNA	ottdart00000001896 (1)	Havana	2,476 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	ottdart00000001898 (1)	Havana	1,410 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	ottdart00000001904 (1)	Havana	180 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-epb41l5	polyclonal	epb41l5		Rabbit	IHC WB		2
Ab2-epb41l5	polyclonal	epb41l5		Guinea pig	IHC		1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations