| ZFIN ID: ZDB-EXP-241104-10 |
Experiment Conditions Description: chemical treatment by environment: (5Z)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidine-2,4-dione
| chemical treatment by environment: (5Z)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidine-2,4-dione |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | (5Z)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidine-2,4-dione |
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| Synonyms: | (5Z)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidine-2,4-dione, 5-(6-quinoxalinylmethylene)-2,4-thiazolidinedione, 5-[(quinoxalin-6-yl)methylidene]-1,3-thiazolidine-2,4-dione, 5-quinoxalin-6-ylmethylene-thiazolidine-2,4-dione, 5-quinoxalin-6-ylmethylenethiazolidine-2,4-dione, AS 605240, AS-605240, AS605240 |
| Definition: | A quinoxaline derivative that is quinoxaline in which the hydrogen at position 6 is replaced by a (2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl group. It is a potent inhibitor of the PI3Kgamma, with an IC50 of 8 nM and inhibits the progression of joint inflammation and damage in both lymphocyte-independent and dependent mouse models of rheumatoid arthritis. |
| Ontology: | ChEBI [CHEBI:45302] ( EBI ) |
| Publication: | Zhou et al., 2022 |
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