Search Ontology:
ChEBI
(5Z)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidine-2,4-dione
- Term ID
- CHEBI:45302
- Synonyms
-
- (5Z)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidine-2,4-dione
- 5-(6-quinoxalinylmethylene)-2,4-thiazolidinedione
- 5-[(quinoxalin-6-yl)methylidene]-1,3-thiazolidine-2,4-dione
- 5-quinoxalin-6-ylmethylene-thiazolidine-2,4-dione
- 5-quinoxalin-6-ylmethylenethiazolidine-2,4-dione
- AS 605240
- AS-605240
- AS605240
- Definition
- A quinoxaline derivative that is quinoxaline in which the hydrogen at position 6 is replaced by a (2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl group. It is a potent inhibitor of the PI3Kγ, with an IC50 of 8 nM and inhibits the progression of joint inflammation and damage in both lymphocyte-independent and dependent mouse models of rheumatoid arthritis.
- References
-
- cas:648450-29-7
- drugbank:DB04769
- lincs.smallmolecule:LSM-42785
- patent:CN101550135
- pdb-ccd:QYT
- pubmed:16127437
- pubmed:19950590
- pubmed:20189103
- pubmed:20510675
- pubmed:20651289
- pubmed:20881611
- pubmed:21866628
- pubmed:22403300
- pubmed:29799846
- pubmed:30571560
- pubmed:31195053
- pubmed:32038117
- pubmed:32882317
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from (5Z)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidine-2,4-dione
Phenotype where environments contain (5Z)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidine-2,4-dione
Phenotype modified by environments containing (5Z)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidine-2,4-dione
Phenotype affecting (5Z)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidine-2,4-dione
Human Disease Model